Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses - Sheahan, Timothy P; Sims, Amy C; Graham, Rachel L; Menachery, Vineet D; Gralinski, Lisa E; Case, James B; Leist, Sarah R; Pyrc, Krzysztof; Feng, Joy Y; Trantcheva, Iva; Bannister, Roy; Park, Yeojin; et al. (Science translational medicine, 2017)
Keywords: Alanine - analogs & derivatives; Alanine - metabolism; Alanine - pharmacokinetics; Alanine - pharmacology; Alanine - toxicity; Animals; Antiviral Agents - metabolism; Antiviral Agents - pharmacokinetics; Antiviral Agents - pharmacology; Antiviral Agents - toxicity; Callithrix; Cell Line; Coronavirus - drug effects; Epidemics; Epithelial Cells - virology; Humans; Lung - pathology; Mice; Ribonucleotides - metabolism; Ribonucleotides - pharmacokinetics; Ribonucleotides - pharmacology; Ribonucleotides - toxicity; Virus Replication - drug effects; Zoonoses - epidemiology; Zoonoses - prevention & control; Zoonoses - virology