Global Quantification of Tissue Dynamics in the Developing Mouse Kidney

• Published in: Developmental cell Vol. 29; no. 2; pp. 188 - 202
• Main Authors: Short, Kieran M., Combes, Alexander N., Lefevre, James, Ju, Adler L., Georgas, Kylie M., Lamberton, Timothy, Cairncross, Oliver, Rumballe, Bree A., McMahon, Andrew P., Hamilton, Nicholas A., Smyth, Ian M., Little, Melissa H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.04.2014
• Subjects: Animals; Cell Count; Embryonic Stem Cells - physiology; Female; Gene Expression Regulation, Developmental; Kidney - cytology; Kidney - embryology; Kidney - physiology; Male; Mice; Mice, Inbred C57BL; Mutation; Nephrons - cytology; Nephrons - embryology; Nephrons - physiology; Phenotype; Pregnancy; Ureter - cytology; Ureter - embryology; Ureter - physiology; Urothelium - cytology; Urothelium - embryology; Urothelium - physiology

Although kidneys of equal size can vary 10-fold in nephron number at birth, discovering what regulates such variation has been hampered by a lack of quantitative parameters defining kidney development. Here we report a comprehensive, quantitative, multiscale analysis of mammalian kidney development...