Global Quantification of Tissue Dynamics in the Developing Mouse Kidney

Although kidneys of equal size can vary 10-fold in nephron number at birth, discovering what regulates such variation has been hampered by a lack of quantitative parameters defining kidney development. Here we report a comprehensive, quantitative, multiscale analysis of mammalian kidney development...

Full description

Saved in:
Bibliographic Details
Published inDevelopmental cell Vol. 29; no. 2; pp. 188 - 202
Main Authors Short, Kieran M., Combes, Alexander N., Lefevre, James, Ju, Adler L., Georgas, Kylie M., Lamberton, Timothy, Cairncross, Oliver, Rumballe, Bree A., McMahon, Andrew P., Hamilton, Nicholas A., Smyth, Ian M., Little, Melissa H.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 28.04.2014
Subjects
Animals
Cell Count
Embryonic Stem Cells - physiology
Female
Gene Expression Regulation, Developmental
Kidney - cytology
Kidney - embryology
Kidney - physiology
Male
Mice
Mice, Inbred C57BL
Mutation
Nephrons - cytology
Nephrons - embryology
Nephrons - physiology
Phenotype
Pregnancy
Ureter - cytology
Ureter - embryology
Ureter - physiology
Urothelium - cytology
Urothelium - embryology
Urothelium - physiology
Online AccessGet full text

Cover

Abstract Although kidneys of equal size can vary 10-fold in nephron number at birth, discovering what regulates such variation has been hampered by a lack of quantitative parameters defining kidney development. Here we report a comprehensive, quantitative, multiscale analysis of mammalian kidney development in which we measure changes in cell number, compartment volumes, and cellular dynamics across the entirety of organogenesis, focusing on two key nephrogenic progenitor populations: the ureteric epithelium and the cap mesenchyme. In doing so, we describe a discontinuous developmental program governed by dynamic changes in interactions between these key cellular populations occurring within a previously unappreciated structurally stereotypic organ architecture. We also illustrate the application of this approach to the detection of a subtle mutant phenotype. This baseline program of kidney morphogenesis provides a framework for assessing genetic and environmental developmental perturbation and will serve as a gold standard for the analysis of other organs. •A comprehensive temporospatial and multiscale profile of normal kidney development•Analysis of structural stereotypy and branch form across development•Dynamic changes in the cap and tip progenitor cell niches over time•Application of the approach to identify a subtle mutant phenotype Short et al. describe a comprehensive, quantitative analysis of shape, cell number, and proliferation rate for key progenitor populations across mammalian kidney development. This reveals a morphogenetic program with structural stereotypy, asynchronous branching, substantial remodeling, and discontinuous nephron induction, elucidating how variation in size and nephron number may arise.
AbstractList Although kidneys of equal size can vary 10-fold in nephron number at birth, discovering what regulates such variation has been hampered by a lack of quantitative parameters defining kidney development. Here we report a comprehensive, quantitative, multiscale analysis of mammalian kidney development in which we measure changes in cell number, compartment volumes, and cellular dynamics across the entirety of organogenesis, focusing on two key nephrogenic progenitor populations: the ureteric epithelium and the cap mesenchyme. In doing so, we describe a discontinuous developmental program governed by dynamic changes in interactions between these key cellular populations occurring within a previously unappreciated structurally stereotypic organ architecture. We also illustrate the application of this approach to the detection of a subtle mutant phenotype. This baseline program of kidney morphogenesis provides a framework for assessing genetic and environmental developmental perturbation and will serve as a gold standard for the analysis of other organs.
Although kidneys of equal size can vary 10-fold in nephron number at birth, discovering what regulates such variation has been hampered by a lack of quantitative parameters defining kidney development. Here we report a comprehensive, quantitative, multiscale analysis of mammalian kidney development in which we measure changes in cell number, compartment volumes, and cellular dynamics across the entirety of organogenesis, focusing on two key nephrogenic progenitor populations: the ureteric epithelium and the cap mesenchyme. In doing so, we describe a discontinuous developmental program governed by dynamic changes in interactions between these key cellular populations occurring within a previously unappreciated structurally stereotypic organ architecture. We also illustrate the application of this approach to the detection of a subtle mutant phenotype. This baseline program of kidney morphogenesis provides a framework for assessing genetic and environmental developmental perturbation and will serve as a gold standard for the analysis of other organs. •A comprehensive temporospatial and multiscale profile of normal kidney development•Analysis of structural stereotypy and branch form across development•Dynamic changes in the cap and tip progenitor cell niches over time•Application of the approach to identify a subtle mutant phenotype Short et al. describe a comprehensive, quantitative analysis of shape, cell number, and proliferation rate for key progenitor populations across mammalian kidney development. This reveals a morphogenetic program with structural stereotypy, asynchronous branching, substantial remodeling, and discontinuous nephron induction, elucidating how variation in size and nephron number may arise.
Author McMahon, Andrew P.
Hamilton, Nicholas A.
Smyth, Ian M.
Little, Melissa H.
Ju, Adler L.
Lamberton, Timothy
Rumballe, Bree A.
Short, Kieran M.
Combes, Alexander N.
Lefevre, James
Georgas, Kylie M.
Cairncross, Oliver
Author_xml – sequence: 1
  givenname: Kieran M.
  surname: Short
  fullname: Short, Kieran M.
  organization: Department of Biochemistry and Molecular Biology, Monash University, Clayton VIC 3800, Australia
– sequence: 2
  givenname: Alexander N.
  surname: Combes
  fullname: Combes, Alexander N.
  organization: Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane QLD 4072, Australia
– sequence: 3
  givenname: James
  surname: Lefevre
  fullname: Lefevre, James
  organization: Division of Genomics & Computational Biology and Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane QLD 4072, Australia
– sequence: 4
  givenname: Adler L.
  surname: Ju
  fullname: Ju, Adler L.
  organization: Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane QLD 4072, Australia
– sequence: 5
  givenname: Kylie M.
  surname: Georgas
  fullname: Georgas, Kylie M.
  organization: Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane QLD 4072, Australia
– sequence: 6
  givenname: Timothy
  surname: Lamberton
  fullname: Lamberton, Timothy
  organization: Division of Genomics & Computational Biology and Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane QLD 4072, Australia
– sequence: 7
  givenname: Oliver
  surname: Cairncross
  fullname: Cairncross, Oliver
  organization: Division of Genomics & Computational Biology and Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane QLD 4072, Australia
– sequence: 8
  givenname: Bree A.
  surname: Rumballe
  fullname: Rumballe, Bree A.
  organization: Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane QLD 4072, Australia
– sequence: 9
  givenname: Andrew P.
  surname: McMahon
  fullname: McMahon, Andrew P.
  organization: Department of Stem Cell Biology and Regenerative Medicine, Broad-CIRM Center for Regenerative Medicine and Stem Cell Research, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
– sequence: 10
  givenname: Nicholas A.
  surname: Hamilton
  fullname: Hamilton, Nicholas A.
  organization: Division of Genomics & Computational Biology and Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane QLD 4072, Australia
– sequence: 11
  givenname: Ian M.
  surname: Smyth
  fullname: Smyth, Ian M.
  email: ian.smyth@monash.edu
  organization: Department of Biochemistry and Molecular Biology, Monash University, Clayton VIC 3800, Australia
– sequence: 12
  givenname: Melissa H.
  surname: Little
  fullname: Little, Melissa H.
  email: m.little@imb.uq.edu.au
  organization: Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane QLD 4072, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24780737$$D View this record in MEDLINE/PubMed
BookMark eNp9kFtLwzAYhoNM3EH_gUgvvWlN0mTtbgSZOsWJCPM6pMkXzWiT2bSD_XszNr306jvwvt_hGaOB8w4QuiQ4I5hMb9aZhq2COqOYsAzTDJPiBI1IWZQp4ZwMYs5zlvISF0M0DmGNo42U-AwNKStiNy9GaLGofSXr5L2XrrPGKtlZ7xJvkpUNoYfkfudkY1VIrEu6r1jDFmq_se4zefV9gOTFage7c3RqZB3g4hgn6OPxYTV_Spdvi-f53TJVrGBdqqnhbJZzagyA4YbCbDY1ZUV1JbWuOFfSyJxiXkoic11yWsipkjTHnFZEVvkEXR_mblr_3UPoRGNDpFBLB_EcQTjFOYuP4ihlB6lqfQgtGLFpbSPbnSBY7BGKtTggFHuEAlMREUbb1XFDXzWg_0y_zKLg9iCA-OfWQiuCsuAUaNuC6oT29v8NP0Ouhhg
CitedBy_id crossref_primary_10_1016_j_gde_2015_03_001
crossref_primary_10_1172_jci_insight_88848
crossref_primary_10_1242_dev_178673
crossref_primary_10_1038_s41390_022_02332_0
crossref_primary_10_1681_ASN_2014090886
crossref_primary_10_1016_j_jtbi_2015_04_015
crossref_primary_10_1016_j_ydbio_2019_11_007
crossref_primary_10_1016_j_cels_2019_08_001
crossref_primary_10_1016_j_stem_2018_10_010
crossref_primary_10_1016_j_semcdb_2018_07_017
crossref_primary_10_1016_j_siny_2021_101245
crossref_primary_10_1159_000481441
crossref_primary_10_1038_s41598_021_00489_y
crossref_primary_10_1038_s41467_018_08212_8
crossref_primary_10_1038_s41581_022_00620_w
crossref_primary_10_1097_MOP_0000000000000324
crossref_primary_10_1242_dev_119735
crossref_primary_10_1016_j_devcel_2021_07_017
crossref_primary_10_1038_nature15695
crossref_primary_10_1016_j_devcel_2014_04_020
crossref_primary_10_1016_j_devcel_2015_09_009
crossref_primary_10_1242_dev_104802
crossref_primary_10_1371_journal_pone_0203623
crossref_primary_10_12688_f1000research_19826_1
crossref_primary_10_1152_ajprenal_00538_2014
crossref_primary_10_1242_dev_197475
crossref_primary_10_1124_dmd_119_089755
crossref_primary_10_1016_j_kint_2021_04_042
crossref_primary_10_1242_dev_140228
crossref_primary_10_1038_nprot_2014_193
crossref_primary_10_1002_dmrr_2805
crossref_primary_10_1016_j_kint_2017_09_015
crossref_primary_10_1083_jcb_201610048
crossref_primary_10_1038_s41598_021_03039_8
crossref_primary_10_15252_embr_201847483
crossref_primary_10_3390_ijms20071779
crossref_primary_10_1016_j_ydbio_2015_05_023
crossref_primary_10_1038_pr_2017_53
crossref_primary_10_1088_1478_3975_abd844
crossref_primary_10_1186_s12935_021_02154_w
crossref_primary_10_14814_phy2_14492
crossref_primary_10_1016_j_devcel_2015_06_021
crossref_primary_10_1096_fj_201902767R
crossref_primary_10_1242_dev_199386
crossref_primary_10_1016_j_ceb_2019_07_001
crossref_primary_10_1038_srep26792
crossref_primary_10_1681_ASN_2020111640
crossref_primary_10_1038_s41467_021_26626_9
crossref_primary_10_1242_dev_184499
crossref_primary_10_14336_AD_2017_0613
crossref_primary_10_1016_j_kint_2016_07_011
crossref_primary_10_1016_j_ydbio_2018_03_020
crossref_primary_10_1186_s13578_022_00801_x
crossref_primary_10_1242_dev_153874
crossref_primary_10_1681_ASN_2017091036
crossref_primary_10_1007_s00467_018_3990_7
crossref_primary_10_1038_srep44810
crossref_primary_10_1681_ASN_2021030320
crossref_primary_10_7554_eLife_64444
crossref_primary_10_1016_j_placenta_2022_12_006
crossref_primary_10_1681_ASN_2018070736
crossref_primary_10_1016_j_devcel_2015_09_023
crossref_primary_10_1038_s41467_018_08127_4
crossref_primary_10_1007_s00467_020_04752_8
crossref_primary_10_1126_sciadv_abn0080
crossref_primary_10_1097_MOT_0000000000000362
crossref_primary_10_1007_s00467_018_4171_4
crossref_primary_10_1111_dgd_12714
crossref_primary_10_1002_dvdy_24387
crossref_primary_10_1371_journal_pgen_1007093
crossref_primary_10_3390_genes12020318
crossref_primary_10_1242_dev_148692
crossref_primary_10_1242_dev_154336
crossref_primary_10_3390_biomedicines12020396
crossref_primary_10_1016_j_cels_2024_06_004
crossref_primary_10_1152_ajprenal_00563_2016
crossref_primary_10_1016_j_ydbio_2018_09_001
crossref_primary_10_1371_journal_pbio_1002382
crossref_primary_10_1016_j_ydbio_2015_04_006
crossref_primary_10_1038_s41467_017_01922_5
crossref_primary_10_1038_srep15209
crossref_primary_10_1152_physiol_00041_2021
crossref_primary_10_1073_pnas_1712955115
crossref_primary_10_3389_fgene_2018_00673
crossref_primary_10_1042_CS20180623
crossref_primary_10_1002_mrd_22973
crossref_primary_10_1016_j_mod_2018_07_005
crossref_primary_10_1007_s00335_014_9551_x
crossref_primary_10_1007_s11538_021_00968_3
crossref_primary_10_1016_j_devcel_2022_12_008
crossref_primary_10_1186_s13073_019_0615_0
crossref_primary_10_1016_j_semcdb_2014_08_014
crossref_primary_10_1242_dev_149112
crossref_primary_10_1101_gad_329573_119
crossref_primary_10_1007_s00467_016_3365_x
crossref_primary_10_3389_fmed_2021_807898
crossref_primary_10_3389_fphys_2018_01588
crossref_primary_10_1002_wdev_338
crossref_primary_10_1152_ajprenal_00383_2023
crossref_primary_10_1007_s00467_016_3326_4
crossref_primary_10_1152_ajprenal_00204_2019
crossref_primary_10_3389_fmed_2024_1363097
crossref_primary_10_1038_nrneph_2016_157
crossref_primary_10_1242_dev_200773
crossref_primary_10_1242_dmm_038604
crossref_primary_10_1177_01926233211035683
crossref_primary_10_3389_fneph_2023_1176347
crossref_primary_10_1038_ncomms12309
crossref_primary_10_3389_fcell_2021_671402
crossref_primary_10_1371_journal_pone_0129242
crossref_primary_10_3389_fcell_2018_00026
crossref_primary_10_1038_s41598_021_01790_6
crossref_primary_10_1111_nep_12407
crossref_primary_10_1681_ASN_2017080887
crossref_primary_10_1002_mrd_22462
crossref_primary_10_1242_dev_157149
crossref_primary_10_1016_j_cell_2017_08_026
crossref_primary_10_1242_bio_042754
crossref_primary_10_1038_s41581_018_0032_4
crossref_primary_10_1007_s00109_020_01978_9
crossref_primary_10_7554_eLife_41156
crossref_primary_10_1038_s41467_023_44410_9
crossref_primary_10_1681_ASN_2020091321
crossref_primary_10_3390_biomedicines9121878
crossref_primary_10_1016_j_ydbio_2020_12_009
crossref_primary_10_1177_0192623319873871
crossref_primary_10_1002_ar_24371
crossref_primary_10_1681_ASN_2017080890
crossref_primary_10_1681_ASN_2019121320
crossref_primary_10_1681_ASN_2016111246
crossref_primary_10_7554_eLife_48183
crossref_primary_10_1098_rstb_2019_0386
crossref_primary_10_1016_j_ekir_2017_01_012
crossref_primary_10_1002_dvdy_24592
crossref_primary_10_1016_j_bbrc_2023_04_052
crossref_primary_10_1016_j_stemcr_2018_08_012
crossref_primary_10_1074_jbc_RA120_013348
crossref_primary_10_1186_s12915_022_01309_z
crossref_primary_10_1038_ncomms10027
crossref_primary_10_1002_path_4690
crossref_primary_10_1016_j_stemcr_2015_07_003
crossref_primary_10_1681_ASN_2021081073
crossref_primary_10_1002_ar_24486
crossref_primary_10_3389_fphys_2021_599529
crossref_primary_10_1016_j_cub_2019_09_021
crossref_primary_10_7554_eLife_38992
crossref_primary_10_1681_ASN_2015121340
crossref_primary_10_37394_23208_2021_18_20
crossref_primary_10_7554_eLife_40392
crossref_primary_10_1038_s41581_022_00598_5
crossref_primary_10_1016_j_celrep_2023_113526
crossref_primary_10_3390_ijms21207754
crossref_primary_10_1016_j_ceb_2019_04_008
crossref_primary_10_1371_journal_pbio_2002842
crossref_primary_10_1038_s41467_021_25714_0
crossref_primary_10_1242_dev_127175
crossref_primary_10_1002_dvdy_24221
crossref_primary_10_1186_s13073_022_01023_z
crossref_primary_10_1007_s00285_018_1208_z
crossref_primary_10_1016_j_cellsig_2020_109548
crossref_primary_10_1016_j_celrep_2016_03_076
crossref_primary_10_1146_annurev_cellbio_100616_060647
crossref_primary_10_1002_term_2924
crossref_primary_10_1038_s41598_017_03808_4
crossref_primary_10_7554_eLife_43271
crossref_primary_10_3389_fcell_2022_953408
Cites_doi 10.1186/1471-213X-11-15
10.1007/s00467-011-1843-8
10.1101/cshperspect.a008300
10.1203/PDR.0b013e3181e35a88
10.1016/j.devcel.2004.11.008
10.1038/ki.2010.42
10.1242/dev.00520
10.1016/j.mod.2013.03.001
10.1093/bioinformatics/btp125
10.1016/j.ydbio.2007.08.021
10.1016/j.ydbio.2009.05.578
10.1016/j.devcel.2009.07.013
10.1016/j.devcel.2010.04.008
10.1371/journal.pone.0017286
10.1016/j.devcel.2005.05.016
10.1016/j.stem.2008.05.020
10.1681/ASN.2007101098
10.1016/j.ydbio.2009.06.043
10.1038/nature07005
10.1002/dvdy.20143
10.1161/01.HYP.0000050961.70182.56
10.1242/dev.00433
10.1016/j.ydbio.2004.03.025
10.1161/01.HYP.0000198544.09909.1a
10.1016/j.jtbi.2013.08.033
10.1126/science.1200037
10.1016/j.ydbio.2007.10.014
10.1242/dev.088500
10.1242/dev.122.6.1919
10.1002/dvdy.23947
10.1016/S0070-2153(10)90005-7
10.1152/ajprenal.00049.2008
10.1242/dev.128.20.3963
10.1002/jez.1402490109
10.1016/j.ydbio.2011.09.011
ContentType Journal Article
Copyright 2014 Elsevier Inc.
Copyright © 2014 Elsevier Inc. All rights reserved.
Copyright_xml – notice: 2014 Elsevier Inc.
– notice: Copyright © 2014 Elsevier Inc. All rights reserved.
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.1016/j.devcel.2014.02.017
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1878-1551
EndPage 202
ExternalDocumentID 10_1016_j_devcel_2014_02_017
24780737
S1534580714001336
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: NIDDK NIH HHS
  grantid: R37 DK054364
GroupedDBID ---
--K
0R~
1~5
2WC
4.4
457
4G.
5GY
5VS
62-
6I.
7-5
AACTN
AAEDT
AAEDW
AAFTH
AAIAV
AAKRW
AALRI
AAQFI
AAUCE
AAVLU
AAXJY
AAXUO
ABJNI
ABMAC
ABMWF
ABVKL
ACGFO
ACGFS
ACNCT
ADBBV
ADEZE
ADJPV
AEFWE
AENEX
AEXQZ
AFFNX
AFTJW
AGHFR
AGKMS
AITUG
ALKID
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ASPBG
AVWKF
AZFZN
BAWUL
CS3
D0L
DIK
DU5
E3Z
EBS
EJD
F5P
FCP
FDB
FEDTE
FIRID
HVGLF
IHE
IXB
J1W
JIG
M3Z
M41
NCXOZ
O-L
O9-
OK1
P2P
RCE
RIG
ROL
RPZ
SDG
SES
SSZ
TR2
WQ6
ZA5
0SF
AAMRU
ADVLN
AKAPO
AKRWK
CGR
CUY
CVF
ECM
EIF
NPM
29F
53G
AAIKJ
AAQXK
AAYXX
ACRPL
ADMUD
ADNMO
CITATION
FGOYB
HZ~
OZT
R2-
UHS
7X8
ID FETCH-LOGICAL-c474t-d2f549352ffeef5f2e996f8b2dbaddb55cafa32058a1a3d8527a6ca23052b1ab3
IEDL.DBID ABVKL
ISSN 1534-5807
IngestDate Fri Oct 25 04:23:32 EDT 2024
Fri Dec 06 03:07:53 EST 2024
Sat Sep 28 08:52:46 EDT 2024
Fri Feb 23 02:26:41 EST 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Language English
License Copyright © 2014 Elsevier Inc. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c474t-d2f549352ffeef5f2e996f8b2dbaddb55cafa32058a1a3d8527a6ca23052b1ab3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink http://www.cell.com/article/S1534580714001336/pdf
PMID 24780737
PQID 1520340160
PQPubID 23479
PageCount 15
ParticipantIDs proquest_miscellaneous_1520340160
crossref_primary_10_1016_j_devcel_2014_02_017
pubmed_primary_24780737
elsevier_sciencedirect_doi_10_1016_j_devcel_2014_02_017
PublicationCentury 2000
PublicationDate 2014-04-28
PublicationDateYYYYMMDD 2014-04-28
PublicationDate_xml – month: 04
  year: 2014
  text: 2014-04-28
  day: 28
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Developmental cell
PublicationTitleAlternate Dev Cell
PublicationYear 2014
Publisher Elsevier Inc
Publisher_xml – name: Elsevier Inc
References Zandi-Nejad, Luyckx, Brenner (bib39) 2006; 47
Schuchardt, D’Agati, Pachnis, Costantini (bib31) 1996; 122
Majumdar, Vainio, Kispert, McMahon, McMahon (bib21) 2003; 130
Keefe Davis, Hoshi, Jain (bib16) 2013; 130
Oliver (bib28) 1968
Short, Hodson, Smyth (bib33) 2010; 77
Little, Georgas, Pennisi, Wilkinson (bib20) 2010; 90
Carroll, Park, Hayashi, Majumdar, McMahon (bib6) 2005; 9
Watanabe, Costantini (bib38) 2004; 271
Wartlick, Mumcu, Kicheva, Bittig, Seum, Jülicher, González-Gaitán (bib37) 2011; 331
Fellows (bib12) 2012; 49
Chi, Michos, Shakya, Riccio, Enomoto, Licht, Asai, Takahashi, Ohgami, Kato (bib8) 2009; 17
Enomoto, Crawford, Gorodinsky, Heuckeroth, Johnson, Milbrandt (bib11) 2001; 128
Georgas, Rumballe, Valerius, Chiu, Thiagarajan, Lesieur, Aronow, Brunskill, Combes, Tang (bib13) 2009; 332
Kobayashi, Valerius, Mugford, Carroll, Self, Oliver, McMahon (bib17) 2008; 3
Shakya, Watanabe, Costantini (bib32) 2005; 8
Wanek, Muneoka, Holler-Dinsmore, Burton, Bryant (bib36) 1989; 249
Gianino, Grider, Cresswell, Enomoto, Heuckeroth (bib14) 2003; 130
Metzger, Klein, Martin, Krasnow (bib25) 2008; 453
Hartman, Lai, Patterson (bib15) 2007; 310
Costantini, Kopan (bib9) 2010; 18
McComb, Cairncross, Noske, Wood, Marsh, Ragan (bib22) 2009; 25
Moritz, Singh, Probyn, Denton (bib26) 2009; 296
Zhang, Quinlan, Hoy, Hughson, Lemire, Hudson, Hueber, Benjamin, Roy, Pascuet (bib40) 2008; 19
Thiagarajan, Georgas, Rumballe, Lesieur, Chiu, Taylor, Tang, Grimmond, Little (bib35) 2011; 6
Boyle, Misfeldt, Chandler, Deal, Southard-Smith, Mortlock, Baldwin, de Caestecker (bib3) 2008; 313
Rumballe, Georgas, Combes, Ju, Gilbert, Little (bib30) 2011; 360
Short, Hodson, Smyth (bib34) 2013; 140
Cullen-McEwen, Kett, Dowling, Anderson, Bertram (bib10) 2003; 41
Cebrián, Borodo, Charles, Herzlinger (bib7) 2004; 231
Lefevre, Marshall, Combes, Ju, Little, Hamilton (bib18) 2013; 338
Little, McMahon (bib19) 2012; 4
Anderson, Wong, Yang, Henkelman (bib1) 2013; 242
Bertram, Douglas-Denton, Diouf, Hughson, Hoy (bib2) 2011; 26
Mugford, Yu, Kobayashi, McMahon (bib27) 2009; 333
Cain, Di Giovanni, Smeeton, Rosenblum (bib5) 2010; 68
Brunskill, Lai, Jamison, Potter, Patterson (bib4) 2011; 11
McDonald (bib23) 2009
(bib29) 2013
Merlet-Bénichou, Gilbert, Vilar, Moreau, Freund, Lelièvre-Pégorier (bib24) 1999; 79
Fellows (10.1016/j.devcel.2014.02.017_bib12) 2012; 49
Wartlick (10.1016/j.devcel.2014.02.017_bib37) 2011; 331
Zandi-Nejad (10.1016/j.devcel.2014.02.017_bib39) 2006; 47
Bertram (10.1016/j.devcel.2014.02.017_bib2) 2011; 26
Chi (10.1016/j.devcel.2014.02.017_bib8) 2009; 17
(10.1016/j.devcel.2014.02.017_bib29) 2013
Kobayashi (10.1016/j.devcel.2014.02.017_bib17) 2008; 3
Schuchardt (10.1016/j.devcel.2014.02.017_bib31) 1996; 122
Majumdar (10.1016/j.devcel.2014.02.017_bib21) 2003; 130
Boyle (10.1016/j.devcel.2014.02.017_bib3) 2008; 313
Thiagarajan (10.1016/j.devcel.2014.02.017_bib35) 2011; 6
Mugford (10.1016/j.devcel.2014.02.017_bib27) 2009; 333
Shakya (10.1016/j.devcel.2014.02.017_bib32) 2005; 8
Merlet-Bénichou (10.1016/j.devcel.2014.02.017_bib24) 1999; 79
Keefe Davis (10.1016/j.devcel.2014.02.017_bib16) 2013; 130
Anderson (10.1016/j.devcel.2014.02.017_bib1) 2013; 242
Little (10.1016/j.devcel.2014.02.017_bib19) 2012; 4
Lefevre (10.1016/j.devcel.2014.02.017_bib18) 2013; 338
Zhang (10.1016/j.devcel.2014.02.017_bib40) 2008; 19
Cebrián (10.1016/j.devcel.2014.02.017_bib7) 2004; 231
Hartman (10.1016/j.devcel.2014.02.017_bib15) 2007; 310
McComb (10.1016/j.devcel.2014.02.017_bib22) 2009; 25
Short (10.1016/j.devcel.2014.02.017_bib34) 2013; 140
Brunskill (10.1016/j.devcel.2014.02.017_bib4) 2011; 11
Oliver (10.1016/j.devcel.2014.02.017_bib28) 1968
Cain (10.1016/j.devcel.2014.02.017_bib5) 2010; 68
Little (10.1016/j.devcel.2014.02.017_bib20) 2010; 90
McDonald (10.1016/j.devcel.2014.02.017_bib23) 2009
Gianino (10.1016/j.devcel.2014.02.017_bib14) 2003; 130
Georgas (10.1016/j.devcel.2014.02.017_bib13) 2009; 332
Moritz (10.1016/j.devcel.2014.02.017_bib26) 2009; 296
Metzger (10.1016/j.devcel.2014.02.017_bib25) 2008; 453
Wanek (10.1016/j.devcel.2014.02.017_bib36) 1989; 249
Watanabe (10.1016/j.devcel.2014.02.017_bib38) 2004; 271
Short (10.1016/j.devcel.2014.02.017_bib33) 2010; 77
Cullen-McEwen (10.1016/j.devcel.2014.02.017_bib10) 2003; 41
Rumballe (10.1016/j.devcel.2014.02.017_bib30) 2011; 360
Enomoto (10.1016/j.devcel.2014.02.017_bib11) 2001; 128
Costantini (10.1016/j.devcel.2014.02.017_bib9) 2010; 18
Carroll (10.1016/j.devcel.2014.02.017_bib6) 2005; 9
References_xml – volume: 77
  start-page: 1132
  year: 2010
  end-page: 1139
  ident: bib33
  article-title: Tomographic quantification of branching morphogenesis and renal development
  publication-title: Kidney Int.
  contributor:
    fullname: Smyth
– volume: 332
  start-page: 273
  year: 2009
  end-page: 286
  ident: bib13
  article-title: Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment
  publication-title: Dev. Biol.
  contributor:
    fullname: Tang
– volume: 68
  start-page: 91
  year: 2010
  end-page: 98
  ident: bib5
  article-title: Genetics of renal hypoplasia: insights into the mechanisms controlling nephron endowment
  publication-title: Pediatr. Res.
  contributor:
    fullname: Rosenblum
– volume: 47
  start-page: 502
  year: 2006
  end-page: 508
  ident: bib39
  article-title: Adult hypertension and kidney disease: the role of fetal programming
  publication-title: Hypertension
  contributor:
    fullname: Brenner
– year: 2013
  ident: bib29
  article-title: R: A language and environment for statistical computing
– volume: 360
  start-page: 110
  year: 2011
  end-page: 122
  ident: bib30
  article-title: Nephron formation adopts a novel spatial topology at cessation of nephrogenesis
  publication-title: Dev. Biol.
  contributor:
    fullname: Little
– volume: 130
  start-page: 506
  year: 2013
  end-page: 518
  ident: bib16
  article-title: Stage specific requirement of Gfrα1 in the ureteric epithelium during kidney development
  publication-title: Mech. Dev.
  contributor:
    fullname: Jain
– volume: 25
  start-page: 1208
  year: 2009
  end-page: 1210
  ident: bib22
  article-title: Illoura: a software tool for analysis, visualization and semantic querying of cellular and other spatial biological data
  publication-title: Bioinformatics
  contributor:
    fullname: Ragan
– start-page: 173
  year: 2009
  end-page: 181
  ident: bib23
  article-title: Handbook of Biological Statistics
  contributor:
    fullname: McDonald
– volume: 242
  start-page: 527
  year: 2013
  end-page: 538
  ident: bib1
  article-title: 3D imaging, registration, and analysis of the early mouse embryonic vasculature
  publication-title: Dev. Dyn.
  contributor:
    fullname: Henkelman
– volume: 8
  start-page: 65
  year: 2005
  end-page: 74
  ident: bib32
  article-title: The role of GDNF/Ret signaling in ureteric bud cell fate and branching morphogenesis
  publication-title: Dev. Cell
  contributor:
    fullname: Costantini
– volume: 231
  start-page: 601
  year: 2004
  end-page: 608
  ident: bib7
  article-title: Morphometric index of the developing murine kidney
  publication-title: Dev. Dyn.
  contributor:
    fullname: Herzlinger
– volume: 338
  start-page: 66
  year: 2013
  end-page: 79
  ident: bib18
  article-title: Modelling cell turnover in a complex tissue during development
  publication-title: J. Theor. Biol.
  contributor:
    fullname: Hamilton
– volume: 271
  start-page: 98
  year: 2004
  end-page: 108
  ident: bib38
  article-title: Real-time analysis of ureteric bud branching morphogenesis in vitro
  publication-title: Dev. Biol.
  contributor:
    fullname: Costantini
– volume: 19
  start-page: 2027
  year: 2008
  end-page: 2034
  ident: bib40
  article-title: A common RET variant is associated with reduced newborn kidney size and function
  publication-title: J. Am. Soc. Nephrol.
  contributor:
    fullname: Pascuet
– volume: 79
  start-page: 515
  year: 1999
  end-page: 527
  ident: bib24
  article-title: Nephron number: variability is the rule. Causes and consequences
  publication-title: Lab. Invest.
  contributor:
    fullname: Lelièvre-Pégorier
– volume: 331
  start-page: 1154
  year: 2011
  end-page: 1159
  ident: bib37
  article-title: Dynamics of Dpp signaling and proliferation control
  publication-title: Science
  contributor:
    fullname: González-Gaitán
– volume: 4
  start-page: a008300
  year: 2012
  ident: bib19
  article-title: Mammalian kidney development: principles, progress, and projections
  publication-title: Cold Spring Harb. Perspect. Biol.
  contributor:
    fullname: McMahon
– volume: 130
  start-page: 2187
  year: 2003
  end-page: 2198
  ident: bib14
  article-title: GDNF availability determines enteric neuron number by controlling precursor proliferation
  publication-title: Development
  contributor:
    fullname: Heuckeroth
– volume: 333
  start-page: 312
  year: 2009
  end-page: 323
  ident: bib27
  article-title: High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population
  publication-title: Dev. Biol.
  contributor:
    fullname: McMahon
– volume: 128
  start-page: 3963
  year: 2001
  end-page: 3974
  ident: bib11
  article-title: RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons
  publication-title: Development
  contributor:
    fullname: Milbrandt
– volume: 453
  start-page: 745
  year: 2008
  end-page: 750
  ident: bib25
  article-title: The branching programme of mouse lung development
  publication-title: Nature
  contributor:
    fullname: Krasnow
– volume: 26
  start-page: 1529
  year: 2011
  end-page: 1533
  ident: bib2
  article-title: Human nephron number: implications for health and disease
  publication-title: Pediatr. Nephrol.
  contributor:
    fullname: Hoy
– volume: 296
  start-page: F1
  year: 2009
  end-page: F9
  ident: bib26
  article-title: Developmental programming of a reduced nephron endowment: more than just a baby’s birth weight
  publication-title: Am. J. Physiol. Renal Physiol.
  contributor:
    fullname: Denton
– volume: 122
  start-page: 1919
  year: 1996
  end-page: 1929
  ident: bib31
  article-title: Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development
  publication-title: Development
  contributor:
    fullname: Costantini
– volume: 17
  start-page: 199
  year: 2009
  end-page: 209
  ident: bib8
  article-title: Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis
  publication-title: Dev. Cell
  contributor:
    fullname: Kato
– volume: 310
  start-page: 379
  year: 2007
  end-page: 387
  ident: bib15
  article-title: Cessation of renal morphogenesis in mice
  publication-title: Dev. Biol.
  contributor:
    fullname: Patterson
– volume: 18
  start-page: 698
  year: 2010
  end-page: 712
  ident: bib9
  article-title: Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
  publication-title: Dev. Cell
  contributor:
    fullname: Kopan
– volume: 249
  start-page: 41
  year: 1989
  end-page: 49
  ident: bib36
  article-title: A staging system for mouse limb development
  publication-title: J. Exp. Zool.
  contributor:
    fullname: Bryant
– volume: 41
  start-page: 335
  year: 2003
  end-page: 340
  ident: bib10
  article-title: Nephron number, renal function, and arterial pressure in aged GDNF heterozygous mice
  publication-title: Hypertension
  contributor:
    fullname: Bertram
– volume: 3
  start-page: 169
  year: 2008
  end-page: 181
  ident: bib17
  article-title: Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development
  publication-title: Cell Stem Cell
  contributor:
    fullname: McMahon
– year: 1968
  ident: bib28
  article-title: Nephrons and kidneys
  contributor:
    fullname: Oliver
– volume: 130
  start-page: 3175
  year: 2003
  end-page: 3185
  ident: bib21
  article-title: Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development
  publication-title: Development
  contributor:
    fullname: McMahon
– volume: 313
  start-page: 234
  year: 2008
  end-page: 245
  ident: bib3
  article-title: Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia
  publication-title: Dev. Biol.
  contributor:
    fullname: de Caestecker
– volume: 49
  start-page: 1
  year: 2012
  end-page: 15
  ident: bib12
  article-title: Deducer: A data analysis GUI for R
  publication-title: J. Stat. Softw.
  contributor:
    fullname: Fellows
– volume: 11
  start-page: 15
  year: 2011
  ident: bib4
  article-title: Microarrays and RNA-Seq identify molecular mechanisms driving the end of nephron production
  publication-title: BMC Dev. Biol.
  contributor:
    fullname: Patterson
– volume: 140
  start-page: 471
  year: 2013
  end-page: 478
  ident: bib34
  article-title: Spatial mapping and quantification of developmental branching morphogenesis
  publication-title: Development
  contributor:
    fullname: Smyth
– volume: 9
  start-page: 283
  year: 2005
  end-page: 292
  ident: bib6
  article-title: Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system
  publication-title: Dev. Cell
  contributor:
    fullname: McMahon
– volume: 90
  start-page: 193
  year: 2010
  end-page: 229
  ident: bib20
  article-title: Kidney development: two tales of tubulogenesis
  publication-title: Curr. Top. Dev. Biol.
  contributor:
    fullname: Wilkinson
– volume: 6
  start-page: e17286
  year: 2011
  ident: bib35
  article-title: Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways
  publication-title: PLoS ONE
  contributor:
    fullname: Little
– volume: 11
  start-page: 15
  year: 2011
  ident: 10.1016/j.devcel.2014.02.017_bib4
  article-title: Microarrays and RNA-Seq identify molecular mechanisms driving the end of nephron production
  publication-title: BMC Dev. Biol.
  doi: 10.1186/1471-213X-11-15
  contributor:
    fullname: Brunskill
– volume: 26
  start-page: 1529
  year: 2011
  ident: 10.1016/j.devcel.2014.02.017_bib2
  article-title: Human nephron number: implications for health and disease
  publication-title: Pediatr. Nephrol.
  doi: 10.1007/s00467-011-1843-8
  contributor:
    fullname: Bertram
– volume: 4
  start-page: a008300
  year: 2012
  ident: 10.1016/j.devcel.2014.02.017_bib19
  article-title: Mammalian kidney development: principles, progress, and projections
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a008300
  contributor:
    fullname: Little
– volume: 68
  start-page: 91
  year: 2010
  ident: 10.1016/j.devcel.2014.02.017_bib5
  article-title: Genetics of renal hypoplasia: insights into the mechanisms controlling nephron endowment
  publication-title: Pediatr. Res.
  doi: 10.1203/PDR.0b013e3181e35a88
  contributor:
    fullname: Cain
– volume: 8
  start-page: 65
  year: 2005
  ident: 10.1016/j.devcel.2014.02.017_bib32
  article-title: The role of GDNF/Ret signaling in ureteric bud cell fate and branching morphogenesis
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2004.11.008
  contributor:
    fullname: Shakya
– volume: 49
  start-page: 1
  year: 2012
  ident: 10.1016/j.devcel.2014.02.017_bib12
  article-title: Deducer: A data analysis GUI for R
  publication-title: J. Stat. Softw.
  contributor:
    fullname: Fellows
– volume: 77
  start-page: 1132
  year: 2010
  ident: 10.1016/j.devcel.2014.02.017_bib33
  article-title: Tomographic quantification of branching morphogenesis and renal development
  publication-title: Kidney Int.
  doi: 10.1038/ki.2010.42
  contributor:
    fullname: Short
– volume: 130
  start-page: 3175
  year: 2003
  ident: 10.1016/j.devcel.2014.02.017_bib21
  article-title: Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development
  publication-title: Development
  doi: 10.1242/dev.00520
  contributor:
    fullname: Majumdar
– volume: 130
  start-page: 506
  year: 2013
  ident: 10.1016/j.devcel.2014.02.017_bib16
  article-title: Stage specific requirement of Gfrα1 in the ureteric epithelium during kidney development
  publication-title: Mech. Dev.
  doi: 10.1016/j.mod.2013.03.001
  contributor:
    fullname: Keefe Davis
– volume: 25
  start-page: 1208
  year: 2009
  ident: 10.1016/j.devcel.2014.02.017_bib22
  article-title: Illoura: a software tool for analysis, visualization and semantic querying of cellular and other spatial biological data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp125
  contributor:
    fullname: McComb
– volume: 310
  start-page: 379
  year: 2007
  ident: 10.1016/j.devcel.2014.02.017_bib15
  article-title: Cessation of renal morphogenesis in mice
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2007.08.021
  contributor:
    fullname: Hartman
– volume: 332
  start-page: 273
  year: 2009
  ident: 10.1016/j.devcel.2014.02.017_bib13
  article-title: Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2009.05.578
  contributor:
    fullname: Georgas
– year: 1968
  ident: 10.1016/j.devcel.2014.02.017_bib28
  contributor:
    fullname: Oliver
– start-page: 173
  year: 2009
  ident: 10.1016/j.devcel.2014.02.017_bib23
  contributor:
    fullname: McDonald
– volume: 17
  start-page: 199
  year: 2009
  ident: 10.1016/j.devcel.2014.02.017_bib8
  article-title: Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2009.07.013
  contributor:
    fullname: Chi
– volume: 18
  start-page: 698
  year: 2010
  ident: 10.1016/j.devcel.2014.02.017_bib9
  article-title: Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2010.04.008
  contributor:
    fullname: Costantini
– volume: 6
  start-page: e17286
  year: 2011
  ident: 10.1016/j.devcel.2014.02.017_bib35
  article-title: Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0017286
  contributor:
    fullname: Thiagarajan
– volume: 9
  start-page: 283
  year: 2005
  ident: 10.1016/j.devcel.2014.02.017_bib6
  article-title: Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2005.05.016
  contributor:
    fullname: Carroll
– volume: 3
  start-page: 169
  year: 2008
  ident: 10.1016/j.devcel.2014.02.017_bib17
  article-title: Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.05.020
  contributor:
    fullname: Kobayashi
– volume: 19
  start-page: 2027
  year: 2008
  ident: 10.1016/j.devcel.2014.02.017_bib40
  article-title: A common RET variant is associated with reduced newborn kidney size and function
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2007101098
  contributor:
    fullname: Zhang
– volume: 333
  start-page: 312
  year: 2009
  ident: 10.1016/j.devcel.2014.02.017_bib27
  article-title: High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2009.06.043
  contributor:
    fullname: Mugford
– volume: 453
  start-page: 745
  year: 2008
  ident: 10.1016/j.devcel.2014.02.017_bib25
  article-title: The branching programme of mouse lung development
  publication-title: Nature
  doi: 10.1038/nature07005
  contributor:
    fullname: Metzger
– volume: 231
  start-page: 601
  year: 2004
  ident: 10.1016/j.devcel.2014.02.017_bib7
  article-title: Morphometric index of the developing murine kidney
  publication-title: Dev. Dyn.
  doi: 10.1002/dvdy.20143
  contributor:
    fullname: Cebrián
– volume: 41
  start-page: 335
  year: 2003
  ident: 10.1016/j.devcel.2014.02.017_bib10
  article-title: Nephron number, renal function, and arterial pressure in aged GDNF heterozygous mice
  publication-title: Hypertension
  doi: 10.1161/01.HYP.0000050961.70182.56
  contributor:
    fullname: Cullen-McEwen
– volume: 130
  start-page: 2187
  year: 2003
  ident: 10.1016/j.devcel.2014.02.017_bib14
  article-title: GDNF availability determines enteric neuron number by controlling precursor proliferation
  publication-title: Development
  doi: 10.1242/dev.00433
  contributor:
    fullname: Gianino
– volume: 271
  start-page: 98
  year: 2004
  ident: 10.1016/j.devcel.2014.02.017_bib38
  article-title: Real-time analysis of ureteric bud branching morphogenesis in vitro
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2004.03.025
  contributor:
    fullname: Watanabe
– volume: 47
  start-page: 502
  year: 2006
  ident: 10.1016/j.devcel.2014.02.017_bib39
  article-title: Adult hypertension and kidney disease: the role of fetal programming
  publication-title: Hypertension
  doi: 10.1161/01.HYP.0000198544.09909.1a
  contributor:
    fullname: Zandi-Nejad
– volume: 338
  start-page: 66
  year: 2013
  ident: 10.1016/j.devcel.2014.02.017_bib18
  article-title: Modelling cell turnover in a complex tissue during development
  publication-title: J. Theor. Biol.
  doi: 10.1016/j.jtbi.2013.08.033
  contributor:
    fullname: Lefevre
– volume: 331
  start-page: 1154
  year: 2011
  ident: 10.1016/j.devcel.2014.02.017_bib37
  article-title: Dynamics of Dpp signaling and proliferation control
  publication-title: Science
  doi: 10.1126/science.1200037
  contributor:
    fullname: Wartlick
– volume: 313
  start-page: 234
  year: 2008
  ident: 10.1016/j.devcel.2014.02.017_bib3
  article-title: Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2007.10.014
  contributor:
    fullname: Boyle
– volume: 140
  start-page: 471
  year: 2013
  ident: 10.1016/j.devcel.2014.02.017_bib34
  article-title: Spatial mapping and quantification of developmental branching morphogenesis
  publication-title: Development
  doi: 10.1242/dev.088500
  contributor:
    fullname: Short
– volume: 122
  start-page: 1919
  year: 1996
  ident: 10.1016/j.devcel.2014.02.017_bib31
  article-title: Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development
  publication-title: Development
  doi: 10.1242/dev.122.6.1919
  contributor:
    fullname: Schuchardt
– year: 2013
  ident: 10.1016/j.devcel.2014.02.017_bib29
– volume: 242
  start-page: 527
  year: 2013
  ident: 10.1016/j.devcel.2014.02.017_bib1
  article-title: 3D imaging, registration, and analysis of the early mouse embryonic vasculature
  publication-title: Dev. Dyn.
  doi: 10.1002/dvdy.23947
  contributor:
    fullname: Anderson
– volume: 90
  start-page: 193
  year: 2010
  ident: 10.1016/j.devcel.2014.02.017_bib20
  article-title: Kidney development: two tales of tubulogenesis
  publication-title: Curr. Top. Dev. Biol.
  doi: 10.1016/S0070-2153(10)90005-7
  contributor:
    fullname: Little
– volume: 296
  start-page: F1
  year: 2009
  ident: 10.1016/j.devcel.2014.02.017_bib26
  article-title: Developmental programming of a reduced nephron endowment: more than just a baby’s birth weight
  publication-title: Am. J. Physiol. Renal Physiol.
  doi: 10.1152/ajprenal.00049.2008
  contributor:
    fullname: Moritz
– volume: 79
  start-page: 515
  year: 1999
  ident: 10.1016/j.devcel.2014.02.017_bib24
  article-title: Nephron number: variability is the rule. Causes and consequences
  publication-title: Lab. Invest.
  contributor:
    fullname: Merlet-Bénichou
– volume: 128
  start-page: 3963
  year: 2001
  ident: 10.1016/j.devcel.2014.02.017_bib11
  article-title: RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons
  publication-title: Development
  doi: 10.1242/dev.128.20.3963
  contributor:
    fullname: Enomoto
– volume: 249
  start-page: 41
  year: 1989
  ident: 10.1016/j.devcel.2014.02.017_bib36
  article-title: A staging system for mouse limb development
  publication-title: J. Exp. Zool.
  doi: 10.1002/jez.1402490109
  contributor:
    fullname: Wanek
– volume: 360
  start-page: 110
  year: 2011
  ident: 10.1016/j.devcel.2014.02.017_bib30
  article-title: Nephron formation adopts a novel spatial topology at cessation of nephrogenesis
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2011.09.011
  contributor:
    fullname: Rumballe
SSID ssj0016180
Score 2.5804226
Snippet Although kidneys of equal size can vary 10-fold in nephron number at birth, discovering what regulates such variation has been hampered by a lack of...
SourceID proquest
crossref
pubmed
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 188
SubjectTerms Animals
Cell Count
Embryonic Stem Cells - physiology
Female
Gene Expression Regulation, Developmental
Kidney - cytology
Kidney - embryology
Kidney - physiology
Male
Mice
Mice, Inbred C57BL
Mutation
Nephrons - cytology
Nephrons - embryology
Nephrons - physiology
Phenotype
Pregnancy
Ureter - cytology
Ureter - embryology
Ureter - physiology
Urothelium - cytology
Urothelium - embryology
Urothelium - physiology
Title Global Quantification of Tissue Dynamics in the Developing Mouse Kidney
URI https://dx.doi.org/10.1016/j.devcel.2014.02.017
https://www.ncbi.nlm.nih.gov/pubmed/24780737
https://search.proquest.com/docview/1520340160
Volume 29
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bS8MwFD6oQ_BFvDsvI4KvZW0ubfeo03mfiJsMX0LSJjAfOtFN8N970rQDQRF8TGlo-JKe84VzzncAjplVaWacPB6644DHYSdQHUMDdC5aM-s0x12h8F0_vhzy65EYLUC3roVxaZWV7fc2vbTW1ZN2hWb7dTxuP-K_ykXqCnAcj2HxIjScljke7cbJ6dPN7TyYEEdlAzX3fuAm1BV0ZZpXbj4y42IQES_FO8vOZT96qN8YaOmJemuwWlFIcuJXuQ4LptiAZd9U8nMTLryMP3mYKZ8IVGJPJpYMSpDJmW9C_07GBUH6R87mdVPkbjJ7N-RmnBfmcwuGvfNB9zKo2iUEGU_4NMipxcseEiprjbHCUoN3GZtqmms0YlqITFnFaChSFSmWp4ImKs4U3kEE1ZHSbBuWiklhdoFYxXNrecfGosOZidMs1GmC3An5oohU0oSghki-elUMWaeLvUgPqXSQypBKhLQJSY2j_La7Eg33HzOPatglHnwXzVCFQTAkEo-QcSeQ14Qdvx_ztVCe4D6zZO_f392HFTdycSOaHsDS9G1mDpF-THWrOl4tWLwaneKo3x3dP38B337Z-Q
link.rule.ids 314,780,784,3506,27569,27924,27925,45663,45874
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ZS8QwEB48EH0Rb9czgq9l2xxt99F7PVYQV9i3kLQJrA_dRXcF_72TpF0QFMHHtikNX9KZL8zMNwCnzKq8ME4eD91xxNO4E6mOoRE6F62ZdZrjrlC495h2X_jdQAzm4KKphXFplbXtDzbdW-v6TrtGsz0eDtvP-K9ykbsCHMdjWDoPi3idOQH928H5LJSQJr59mhsdueFN_ZxP8irNR2FcBCLhXrrT9y370T_9xj-9H7peg9WaQJKzMMd1mDPVBiyFlpKfm3ATRPzJ01SFNCCPPBlZ0vcQk8vQgv6dDCuC5I9czqqmSG80fTfkflhW5nMLXq6v-hfdqG6WEBU845OopBaPekinrDXGCksNnmRsrmmp0YRpIQplFaOxyFWiWJkLmqm0UHgCEVQnSrNtWKhGldkFYhUvreUdm4oOZybNi1jnGTInZIsiUVkLogYiOQ6aGLJJFnuVAVLpIJUxlQhpC7IGR_ltbSWa7T_ePGlgl7jtXSxDVQbBkEg7YsadPF4LdsJ6zOZCeYbrzLK9f3_3GJa7_d6DfLh9vN-HFffERZBofgALk7epOUQiMtFHfqN9AebQ2Qs
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Global+Quantification+of+Tissue+Dynamics+in+the+Developing+Mouse+Kidney&rft.jtitle=Developmental+cell&rft.au=Short%2C+Kieran%C2%A0M.&rft.au=Combes%2C+Alexander%C2%A0N.&rft.au=Lefevre%2C+James&rft.au=Ju%2C+Adler%C2%A0L.&rft.date=2014-04-28&rft.issn=1534-5807&rft.volume=29&rft.issue=2&rft.spage=188&rft.epage=202&rft_id=info:doi/10.1016%2Fj.devcel.2014.02.017&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_devcel_2014_02_017
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1534-5807&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1534-5807&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1534-5807&client=summon