Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates

• Published in: Developmental cell Vol. 55; no. 1; pp. 30 - 44
• Main Authors: Zhao, Yan G., Zhang, Hong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.10.2020
• Subjects: Autophagosomes - metabolism; autophagy; Biology - methods; Biophysical Phenomena - physiology; Cell Physiological Phenomena - physiology; condensates; Humans; membrane-bound organelles; Membranes - metabolism; Organelles - metabolism; phase separation; vesicle trafficking; phase separation; condensates; autophagy; membrane-bound organelles; vesicle trafficking

In eukaryotic cells, various membrane-bound organelles compartmentalize diverse cellular activities in a spatially and temporally controlled manner. Numerous membraneless organelles assembled via liquid-liquid phase separation (LLPS), known as condensates, also facilitate compartmentalization of cel...