Chronic kidney disease induced by an adenine rich diet upregulates integrin linked kinase (ILK) and its depletion prevents the disease progression

• Published in: Biochimica et biophysica acta. Molecular basis of disease Vol. 1865; no. 6; pp. 1284 - 1297
• Main Authors: de Frutos, Sergio, Luengo, Alicia, García-Jérez, Andrea, Hatem-Vaquero, Marco, Griera, Mercedes, O'Valle, Francisco, Rodríguez–Puyol, Manuel, Rodríguez–Puyol, Diego, Calleros, Laura
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2019
• Subjects: Actins - genetics; Actins - metabolism; Adenine - administration & dosage; Animals; Cadherins - genetics; Cadherins - metabolism; Chronic renal disease; Creatinine - blood; Diet; Disease Models, Animal; Epithelial-to-mesenchymal transition; Extracellular Matrix - metabolism; Extracellular Matrix - pathology; Fibrosis; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Inflammation; Integrin-linked kinase; Kidney Tubules - metabolism; Kidney Tubules - pathology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein-Serine-Threonine Kinases - deficiency; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Renal Insufficiency, Chronic - chemically induced; Renal Insufficiency, Chronic - genetics; Renal Insufficiency, Chronic - metabolism; Renal Insufficiency, Chronic - pathology; Signal Transduction; Snail Family Transcription Factors - genetics; Snail Family Transcription Factors - metabolism; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - metabolism; Tubulointerstitial damage; Urea - blood; Chronic renal disease; Integrin-linked kinase; Inflammation; Tubulointerstitial damage; Epithelial-to-mesenchymal transition; Fibrosis

Kidney fibrosis is one of the main pathological findings of progressive chronic kidney disease (CKD) although the pathogenesis of renal scar formation remains incompletely explained. Integrin-linked kinase (ILK), a major scaffold protein between the extracellular matrix (ECM) and intracellular signa...