Targeting of somatic hypermutation

• Published in: Nature Reviews: Immunology Vol. 6; no. 8; pp. 573 - 583
• Main Authors: Odegard, Valerie H., Schatz, David G.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2006; Nature Publishing Group
• Subjects: Adenosine; Animals; Antigens; Biomedical and Life Sciences; Biomedicine; Cytidine Deaminase - genetics; Cytidine Deaminase - metabolism; Enhancer Elements, Genetic - genetics; Genes; Histones - genetics; Histones - metabolism; Humans; Immunoglobulins; Immunoglobulins - genetics; Immunology; Light; Lymphoma, B-Cell - genetics; Lymphoma, B-Cell - immunology; Models, Genetic; Mutation; review-article; RNA polymerase; Somatic Hypermutation, Immunoglobulin - genetics; United States > US; Connecticut
• ISSN: 1474-1733; 1474-1741; 1365-2567
• DOI: 10.1038/nri1896

Key Points The targeting of somatic hypermutation (SHM) occurs at two distinct levels. 'Global' targeting refers to the fact that rearranged immunoglobulin variable regions are the primary substrate for SHM. By contrast, 'local' targeting refers to the observation that mutations...