Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

• Published in: Nature medicine Vol. 18; no. 9; pp. 1407 - 1412
• Main Authors: Talukdar, Saswata, Oh, Da Young, Bandyopadhyay, Gautam, Li, Dongmei, Xu, Jianfeng, McNelis, Joanne, Lu, Min, Li, Pingping, Yan, Qingyun, Zhu, Yimin, Ofrecio, Jachelle, Lin, Michael, Brenner, Martin B, Olefsky, Jerrold M
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.09.2012; Nature Publishing Group
• Subjects: 631/250/2504/223/1699; 631/250/256; 692/699/2743/393; Adipose tissue; Animals; Antigen presentation; Biomedical and Life Sciences; Biomedicine; Blotting, Western; Body fat; Body Weight - drug effects; Cancer Research; Densitometry; Diet; Diet, High-Fat; Flow Cytometry; Hepatocytes - drug effects; Immune system; Infectious Diseases; Inflammation - etiology; Inflammation - immunology; Insulin resistance; Insulin Resistance - immunology; letter; Liver diseases; Metabolic Diseases; Metabolic disorders; Mice; Molecular Medicine; Neurosciences; Neutrophils - immunology; Neutrophils - secretion; Obesity; Obesity - complications; Pancreatic Elastase - pharmacology; Pancreatic Elastase - secretion; Real-Time Polymerase Chain Reaction

Infiltration of various immune cell types into the fat tissue and liver has been implicated in obesity-induced insulin resistance. Jerry Olefsky and his colleagues now show that neutrophils are one of the earliest immune cells to arrive in these tissues, that they release the protease neutrophil ela...