ER-stress and apoptosis: molecular mechanisms and potential relevance in infection
During ER-stress, one of the responses a cell can choose is apoptosis. Apoptosis generally is a cell's preferred response when other control mechanisms are overwhelmed. We now have a reasonably clear molecular picture what is happening once the apoptotic apparatus has been started. Unclear howe...
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Published in | Microbes and infection Vol. 16; no. 10; pp. 805 - 810 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
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Elsevier Masson SAS
01.10.2014
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Abstract | During ER-stress, one of the responses a cell can choose is apoptosis. Apoptosis generally is a cell's preferred response when other control mechanisms are overwhelmed. We now have a reasonably clear molecular picture what is happening once the apoptotic apparatus has been started. Unclear however are the majority of the upstream pathways that connect other signalling to apoptosis. During ER-stress, confirmed apoptosis-regulating targets are pro- and anti-apoptotic proteins of the Bcl-2-family, whose concerted action induces apoptosis. I will here discuss how mitochondrial apoptosis is triggered, how this is linked to the ER-stress response and in what way this may be relevant during microbial infections. |
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AbstractList | During ER-stress, one of the responses a cell can choose is apoptosis. Apoptosis generally is a cell's preferred response when other control mechanisms are overwhelmed. We now have a reasonably clear molecular picture what is happening once the apoptotic apparatus has been started. Unclear however are the majority of the upstream pathways that connect other signalling to apoptosis. During ER-stress, confirmed apoptosis-regulating targets are pro- and anti-apoptotic proteins of the Bcl-2-family, whose concerted action induces apoptosis. I will here discuss how mitochondrial apoptosis is triggered, how this is linked to the ER-stress response and in what way this may be relevant during microbial infections. |
Author | Häcker, Georg |
Author_xml | – sequence: 1 givenname: Georg surname: Häcker fullname: Häcker, Georg email: georg.haecker@uniklinik-freiburg.de organization: Institute for Medical Microbiology and Hygiene, University Medical Centre Freiburg, Hermann Herder-Str. 11, D-79104 Freiburg, Germany |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25172397$$D View this record in MEDLINE/PubMed |
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Keywords | Bcl-2 Infection ER-stress Apoptosis |
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Snippet | During ER-stress, one of the responses a cell can choose is apoptosis. Apoptosis generally is a cell's preferred response when other control mechanisms are... |
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SubjectTerms | Apoptosis Apoptosis - physiology Bcl-2 Communicable Diseases - metabolism Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress - physiology ER-stress Humans Infection Mitochondria - genetics Mitochondria - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism |
Title | ER-stress and apoptosis: molecular mechanisms and potential relevance in infection |
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