Cytohesin-3 is required for full insulin receptor signaling and controls body weight via lipid excretion

• Published in: Scientific reports Vol. 9; no. 1; p. 3442
• Main Authors: Jux, Bettina, Gosejacob, Dominic, Tolksdorf, Felix, Mandel, Christa, Rieck, Michael, Namislo, Angrit, Pfeifer, Alexander, Kolanus, Waldemar
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.03.2019; Nature Publishing Group
• Subjects: 38; 38/77; 631/80/86; 631/80/86/2367; 64; 64/60; 96/1; 96/95; Adipose tissue; Age; Blood glucose; Body fat; Body weight; Body weight gain; Energy expenditure; Excretion; Guanine; Guanine nucleotide exchange factor; High fat diet; Homeostasis; Humanities and Social Sciences; Insulin; Liver; Metabolism; multidisciplinary; Science; Science (multidisciplinary); Signal transduction; Therapeutic applications

Insulin plays a central role in regulating metabolic homeostasis and guanine-nucleotide exchange factors of the cytohesin family have been suggested to be involved in insulin signal transduction. The Drosophila homolog of cytohesin-3, steppke , has been shown to be essential for insulin signaling du...