Upregulation of prefrontal metabotropic glutamate receptor 5 mediates neuropathic pain and negative mood symptoms after spinal nerve injury in rats
Patients with chronic pain easily accompany the negative mood symptoms such as depression and anxiety, and these disturbances in turn affect the aversive perception of pain. However, the underlying mechanisms are largely unknown. We hypothesized that the alteration of metabotropic glutamate receptor...
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Published in | Scientific reports Vol. 7; no. 1; pp. 9743 - 14 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Nature Publishing Group UK
29.08.2017
Nature Publishing Group |
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Abstract | Patients with chronic pain easily accompany the negative mood symptoms such as depression and anxiety, and these disturbances in turn affect the aversive perception of pain. However, the underlying mechanisms are largely unknown. We hypothesized that the alteration of metabotropic glutamate receptor 5 (mGluR5) in the brain region underlies such a comorbidity of aversive states. We scanned the brain of chronic neuropathic pain model rats using positron emission tomography (PET) technique with an mGluR5-selective radiotracer [11C] ABP688 and found various brain regions with higher or lower level of mGluR5 compared to control rats. Among the brain areas, a prominent upregulation of mGluR5 was shown in the prelimbic region (PrL) of the medial prefrontal cortex (mPFC) of chronic neuropathic pain animals. A pharmacological blockade of upregulated mGluR5 in the PrL ameliorated the negative symptoms including tactile hypersensitivity and depressive-like behavior, which relieved the subjects from the unpleasant state of chronic neuropathic pain condition. Conversely, lentiviral overexpression of the mGluR5 in the PrL of naïve rats successfully induced comorbid pain and negative moods. Our data provide deeper insight into the shared mechanism of pain perception and negative emotions, identifying a therapeutic target for the treatment of chronic pain and mood disorders. |
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AbstractList | Patients with chronic pain easily accompany the negative mood symptoms such as depression and anxiety, and these disturbances in turn affect the aversive perception of pain. However, the underlying mechanisms are largely unknown. We hypothesized that the alteration of metabotropic glutamate receptor 5 (mGluR5) in the brain region underlies such a comorbidity of aversive states. We scanned the brain of chronic neuropathic pain model rats using positron emission tomography (PET) technique with an mGluR5-selective radiotracer [11C] ABP688 and found various brain regions with higher or lower level of mGluR5 compared to control rats. Among the brain areas, a prominent upregulation of mGluR5 was shown in the prelimbic region (PrL) of the medial prefrontal cortex (mPFC) of chronic neuropathic pain animals. A pharmacological blockade of upregulated mGluR5 in the PrL ameliorated the negative symptoms including tactile hypersensitivity and depressive-like behavior, which relieved the subjects from the unpleasant state of chronic neuropathic pain condition. Conversely, lentiviral overexpression of the mGluR5 in the PrL of naïve rats successfully induced comorbid pain and negative moods. Our data provide deeper insight into the shared mechanism of pain perception and negative emotions, identifying a therapeutic target for the treatment of chronic pain and mood disorders. Abstract Patients with chronic pain easily accompany the negative mood symptoms such as depression and anxiety, and these disturbances in turn affect the aversive perception of pain. However, the underlying mechanisms are largely unknown. We hypothesized that the alteration of metabotropic glutamate receptor 5 (mGluR5) in the brain region underlies such a comorbidity of aversive states. We scanned the brain of chronic neuropathic pain model rats using positron emission tomography (PET) technique with an mGluR5-selective radiotracer [11C] ABP688 and found various brain regions with higher or lower level of mGluR5 compared to control rats. Among the brain areas, a prominent upregulation of mGluR5 was shown in the prelimbic region (PrL) of the medial prefrontal cortex (mPFC) of chronic neuropathic pain animals. A pharmacological blockade of upregulated mGluR5 in the PrL ameliorated the negative symptoms including tactile hypersensitivity and depressive-like behavior, which relieved the subjects from the unpleasant state of chronic neuropathic pain condition. Conversely, lentiviral overexpression of the mGluR5 in the PrL of naïve rats successfully induced comorbid pain and negative moods. Our data provide deeper insight into the shared mechanism of pain perception and negative emotions, identifying a therapeutic target for the treatment of chronic pain and mood disorders. |
ArticleNumber | 9743 |
Author | Kim, Sang Jeong Chung, Geehoon Kim, Yu Kyeong Yoon, Sang Ho Kim, Myoung-Hwan Kim, Chae Young Yun, Yeong-Chan |
Author_xml | – sequence: 1 givenname: Geehoon orcidid: 0000-0003-0771-4391 surname: Chung fullname: Chung, Geehoon organization: Department of Physiology, Seoul National University College of Medicine, Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences – sequence: 2 givenname: Chae Young surname: Kim fullname: Kim, Chae Young organization: Department of Physiology, Seoul National University College of Medicine, Department of Biomedical Sciences, Seoul National University College of Medicine – sequence: 3 givenname: Yeong-Chan surname: Yun fullname: Yun, Yeong-Chan organization: Department of Physiology, Seoul National University College of Medicine – sequence: 4 givenname: Sang Ho surname: Yoon fullname: Yoon, Sang Ho organization: Department of Physiology, Seoul National University College of Medicine, Department of Biomedical Sciences, Seoul National University College of Medicine – sequence: 5 givenname: Myoung-Hwan surname: Kim fullname: Kim, Myoung-Hwan organization: Department of Physiology, Seoul National University College of Medicine, Department of Biomedical Sciences, Seoul National University College of Medicine – sequence: 6 givenname: Yu Kyeong surname: Kim fullname: Kim, Yu Kyeong organization: Department of Nuclear Medicine, Seoul National University College of Medicine – sequence: 7 givenname: Sang Jeong orcidid: 0000-0001-8931-3713 surname: Kim fullname: Kim, Sang Jeong email: sangjkim@snu.ac.kr organization: Department of Physiology, Seoul National University College of Medicine, Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Department of Biomedical Sciences, Seoul National University College of Medicine, Neuroscience Research Institute, Seoul National University College of Medicine |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28851991$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/j.tins.2008.01.003 10.1016/j.neubiorev.2014.08.002 10.1212/01.WNL.0000156353.17305.52 10.2174/187152707780363302 10.1016/S0165-0270(03)00192-4 10.1007/s00406-013-0399-y 10.1038/tp.2015.189 10.1093/rheumatology/kel363 10.1016/j.pain.2004.12.001 10.1016/j.bbr.2014.04.042 10.1073/pnas.0809897106 10.1038/nrn3516 10.1038/ncomms8660 10.1002/syn.10279 10.1016/j.brainres.2010.07.023 10.1038/npp.2012.101 10.1002/cne.902900205 10.1016/j.tics.2010.11.004 10.1007/s40473-015-0050-5 10.1016/S0306-4522(96)00380-6 10.1016/j.ejphar.2015.03.024 10.1016/0304-3959(92)90041-9 10.1016/j.bcp.2007.09.021 10.1172/JCI82859 10.1016/j.celrep.2015.07.001 10.1016/j.jneumeth.2010.12.015 10.1016/j.neuropharm.2012.04.007 10.1016/j.biopsych.2014.06.018 10.1124/jpet.114.222463 10.1159/000435929 10.1016/j.neuroimage.2009.05.068 10.1016/0165-0270(94)90144-9 10.1176/appi.ajp.2011.09111607 10.1038/nprot.2012.044 10.1523/JNEUROSCI.5173-08.2009 10.4065/mcp.2009.0648 10.1016/j.bpsc.2017.03.019 10.1016/j.pain.2014.02.019 10.1016/j.pnpbp.2012.12.012 10.1016/j.pharmthera.2007.04.007 10.1213/01.ane.0000261514.19946.66 10.1523/JNEUROSCI.0799-15.2015 10.1517/13543784.2015.1074175 10.1038/mp.2015.132 10.1523/JNEUROSCI.3576-06.2006 10.1038/nm.4050 10.1212/WNL.0000000000003243 10.1080/01621459.1965.10480843 10.1016/j.neuroscience.2015.06.008 10.1016/j.neuropharm.2012.05.022 10.1038/nn.2921 10.1038/mp.2015.91 10.1038/nn.2407 10.1007/s00018-008-8428-0 10.1016/j.neuroimage.2014.01.020 10.1038/nn.4028 10.1038/nrn3677 10.1097/BRS.0000000000001930 10.1038/mp.2017.58 10.1002/j.1532-2149.2013.00334.x 10.1523/ENEURO.0002-16.2016 10.1016/S0301-0082(98)00095-1 10.1016/j.jad.2010.11.034 10.1016/bs.pmbts.2014.12.003 10.1126/science.1253994 |
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References | Leite-Almeida, Pinto-Ribeiro, Almeida (CR13) 2015; 30 Sesack, Deutch, Roth, Bunney (CR36) 1989; 290 McEwen (CR27) 2012; 37 DeLorenzo (CR47) 2015; 5 Hashimoto, Malchow, Falkai, Schmitt (CR54) 2013; 263 Lindemann (CR59) 2015; 353 CR38 Seifert, Maihöfner (CR3) 2009; 66 Metz, Yau, Centeno, Apkarian, Martina (CR2) 2009; 106 CR35 CR32 Deschwanden (CR46) 2011; 168 Ho Kim, Mo Chung (CR23) 1992; 50 Pilc, Chaki, Nowak, Witkin (CR52) 2008; 75 Park, Niciu, Zarate (CR60) 2015; 2 Zhang (CR31) 2015; 12 Schweinhardt, Fransson, Olson, Spenger, Andersson (CR63) 2003; 129 Li (CR11) 2015; 276 Benarroch (CR43) 2016; 87 Thompson (CR6) 2014; 91 Fuxe, Borroto-Escuela (CR55) 2015; 24 Shi, Qi, Gao, Wang, Luo (CR10) 2010; 1353 Witkin, Marek, Johnson, Schoepp (CR51) 2007; 6 Abdallah (CR49) 2017 Mezadri, Batista, Portes, Marino-Neto, Lino-de-Oliveira (CR65) 2011; 195 Chang, Pollema-Mays, Centeno, Procissi, Contini, Baria, Martina, Apkarian (CR40) 2014; 155 Shin (CR67) 2015; 18 Bushnell, Čeko, Low (CR20) 2013; 14 Esterlis (CR45) 2017 Duman, Aghajanian, Sanacora, Krystal (CR18) 2016; 22 Wang (CR50) 2015; 301 Marsden (CR17) 2013; 43 Hoppa (CR37) 2015; 84 Maihöfner, Forster, Birklein, Neundörfer, Handwerker (CR4) 2005; 114 Kaneko (CR42) 2017; 42 Bannerman (CR19) 2014; 15 King (CR66) 2009; 12 Baliki (CR22) 2006; 26 Starr (CR39) 2009; 29 CR16 Lee (CR29) 2015; 20 Chaplan, Bach, Pogrel, Chung, Yaksh (CR62) 1994; 53 Kim (CR14) 2016; 126 Kato (CR56) 2015; 757 Etkin, Egner, Kalisch (CR28) 2011; 15 Zhuo (CR1) 2008; 31 Turk, Audette, Levy, Mackey, Stanos (CR9) 2010; 85 Matos, Zhang, Seguela (CR15) 2015; 35 Wang (CR30) 2015; 6 Schreckenberger (CR41) 2005; 64 Gray, Hyde, Deep-Soboslay, Kleinman, Sodhi (CR48) 2015; 20 Kelly, Huang, Meltzer, Martina (CR44) 2016; 10 Treadway (CR25) 2015; 77 Gorelova, Yang (CR33) 1996; 76 CR24 Yalcin, Barthas, Barrot (CR21) 2014; 47 Vertes (CR34) 2004; 51 Seminowicz (CR5) 2009; 47 Palucha, Pilc (CR53) 2007; 115 Gupta (CR8) 2007; 46 Chaki, Ago, Palucha-Paniewiera, Matrisciano, Pilc (CR58) 2013; 66 Slattery (CR64) 2012; 7 Radat, Margot-Duclot, Attal (CR7) 2013; 17 Hughes (CR57) 2013; 66 Suzuki (CR12) 2007; 104 Alexander, Brown (CR26) 2012; 14 Dixon (CR61) 1965; 60 29880903 - Sci Rep. 2018 Jun 7;8(1):8936 29410506 - Sci Rep. 2018 Feb 6;8(1):2744 DC Turk (9991_CR9) 2010; 85 9991_CR24 I Esterlis (9991_CR45) 2017 MT Treadway (9991_CR25) 2015; 77 L Lindemann (9991_CR59) 2015; 353 T Suzuki (9991_CR12) 2007; 104 F Seifert (9991_CR3) 2009; 66 CJ Starr (9991_CR39) 2009; 29 S Shin (9991_CR67) 2015; 18 AE Metz (9991_CR2) 2009; 106 A Deschwanden (9991_CR46) 2011; 168 G-Q Wang (9991_CR30) 2015; 6 EE Benarroch (9991_CR43) 2016; 87 F Radat (9991_CR7) 2013; 17 SR Sesack (9991_CR36) 1989; 290 9991_CR38 S Chaki (9991_CR58) 2013; 66 RS Duman (9991_CR18) 2016; 22 9991_CR35 Z Zhang (9991_CR31) 2015; 12 MC Bushnell (9991_CR20) 2013; 14 N Gorelova (9991_CR33) 1996; 76 K Hashimoto (9991_CR54) 2013; 263 AL Gray (9991_CR48) 2015; 20 C DeLorenzo (9991_CR47) 2015; 5 WJ Dixon (9991_CR61) 1965; 60 WN Marsden (9991_CR17) 2013; 43 A Palucha (9991_CR53) 2007; 115 P Schweinhardt (9991_CR63) 2003; 129 D Slattery (9991_CR64) 2012; 7 9991_CR32 MB Hoppa (9991_CR37) 2015; 84 A Gupta (9991_CR8) 2007; 46 SJ Thompson (9991_CR6) 2014; 91 DM Bannerman (9991_CR19) 2014; 15 RP Vertes (9991_CR34) 2004; 51 CJ Kelly (9991_CR44) 2016; 10 TJ Mezadri (9991_CR65) 2011; 195 M Shi (9991_CR10) 2010; 1353 Pei-Ching Chang (9991_CR40) 2014; 155 I Yalcin (9991_CR21) 2014; 47 A Etkin (9991_CR28) 2011; 15 AM McEwen (9991_CR27) 2012; 37 SC Matos (9991_CR15) 2015; 35 Y Wang (9991_CR50) 2015; 301 A Pilc (9991_CR52) 2008; 75 H Leite-Almeida (9991_CR13) 2015; 30 JM Witkin (9991_CR51) 2007; 6 9991_CR16 S Ho Kim (9991_CR23) 1992; 50 M Schreckenberger (9991_CR41) 2005; 64 JX Li (9991_CR11) 2015; 276 DA Seminowicz (9991_CR5) 2009; 47 K Fuxe (9991_CR55) 2015; 24 C Maihöfner (9991_CR4) 2005; 114 CG Abdallah (9991_CR49) 2017 MN Baliki (9991_CR22) 2006; 26 ZA Hughes (9991_CR57) 2013; 66 WH Alexander (9991_CR26) 2012; 14 T Kato (9991_CR56) 2015; 757 T King (9991_CR66) 2009; 12 SK Kim (9991_CR14) 2016; 126 K-W Lee (9991_CR29) 2015; 20 SR Chaplan (9991_CR62) 1994; 53 M Zhuo (9991_CR1) 2008; 31 H Kaneko (9991_CR42) 2017; 42 M Park (9991_CR60) 2015; 2 |
References_xml | – volume: 31 start-page: 199 year: 2008 end-page: 207 ident: CR1 article-title: Cortical excitation and chronic pain publication-title: Trends Neurosci. doi: 10.1016/j.tins.2008.01.003 contributor: fullname: Zhuo – volume: 47 start-page: 154 year: 2014 end-page: 164 ident: CR21 article-title: Emotional consequences of neuropathic pain: Insight from preclinical studies publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2014.08.002 contributor: fullname: Barrot – volume: 64 start-page: 1175 year: 2005 end-page: 1183 ident: CR41 article-title: The unpleasantness of tonic pain is encoded by the insular cortex publication-title: Neurology doi: 10.1212/01.WNL.0000156353.17305.52 contributor: fullname: Schreckenberger – volume: 6 start-page: 87 year: 2007 end-page: 100 ident: CR51 article-title: Metabotropic glutamate receptors in the control of mood disorders publication-title: CNS Neurol Disord Drug Targets doi: 10.2174/187152707780363302 contributor: fullname: Schoepp – volume: 129 start-page: 105 year: 2003 end-page: 113 ident: CR63 article-title: A template for spatial normalisation of MR images of the rat brain publication-title: J. Neurosci. Methods doi: 10.1016/S0165-0270(03)00192-4 contributor: fullname: Andersson – ident: CR16 – volume: 263 start-page: 367 year: 2013 end-page: 377 ident: CR54 article-title: Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders publication-title: Eur. Arch. Psychiatry Clin. Neurosci. doi: 10.1007/s00406-013-0399-y contributor: fullname: Schmitt – volume: 5 year: 2015 ident: CR47 article-title: Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [(1)(1)C]ABP688 publication-title: Transl. Psychiatry doi: 10.1038/tp.2015.189 contributor: fullname: DeLorenzo – volume: 46 start-page: 666 year: 2007 end-page: 671 ident: CR8 article-title: The role of psychosocial factors in predicting the onset of chronic widespread pain: Results from a prospective population-based study publication-title: Rheumatology doi: 10.1093/rheumatology/kel363 contributor: fullname: Gupta – volume: 114 start-page: 93 year: 2005 end-page: 103 ident: CR4 article-title: Brain processing during mechanical hyperalgesia in complex regional pain syndrome: A functional MRI study publication-title: Pain doi: 10.1016/j.pain.2004.12.001 contributor: fullname: Handwerker – volume: 276 start-page: 92 year: 2015 end-page: 98 ident: CR11 article-title: Pain and depression comorbidity: A preclinical perspective publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2014.04.042 contributor: fullname: Li – volume: 106 start-page: 2423 year: 2009 end-page: 2428 ident: CR2 article-title: Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0809897106 contributor: fullname: Martina – ident: CR35 – volume: 14 start-page: 502 year: 2013 end-page: 511 ident: CR20 article-title: Cognitive and emotional control of pain and its disruption in chronic pain publication-title: Nat Rev Neurosci doi: 10.1038/nrn3516 contributor: fullname: Low – volume: 6 year: 2015 ident: CR30 article-title: Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety publication-title: Nat. Commun. doi: 10.1038/ncomms8660 contributor: fullname: Wang – volume: 84 start-page: 778 year: 2015 end-page: 789 ident: CR37 article-title: Connectivity of mouse somatosensory and prefrontal cortex examined with trans-synaptic tracing publication-title: Nat. Neurosci. contributor: fullname: Hoppa – volume: 51 start-page: 32 year: 2004 end-page: 58 ident: CR34 article-title: Differential Projections of the Infralimbic and Prelimbic Cortex in the Rat publication-title: Synapse doi: 10.1002/syn.10279 contributor: fullname: Vertes – volume: 1353 start-page: 225 year: 2010 end-page: 233 ident: CR10 article-title: Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors publication-title: Brain Res. doi: 10.1016/j.brainres.2010.07.023 contributor: fullname: Luo – volume: 37 start-page: 2428 year: 2012 end-page: 2435 ident: CR27 article-title: Increased Glutamate Levels in the Medial Prefrontal Cortex in Patients with Postpartum Depression publication-title: Neuropsychopharmacology doi: 10.1038/npp.2012.101 contributor: fullname: McEwen – volume: 290 start-page: 213 year: 1989 end-page: 242 ident: CR36 article-title: Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin publication-title: J. Comp. Neurol. doi: 10.1002/cne.902900205 contributor: fullname: Bunney – volume: 15 start-page: 85 year: 2011 end-page: 93 ident: CR28 article-title: Emotional processing in anterior cingulate and medial prefrontal cortex publication-title: Trends in Cognitive Sciences doi: 10.1016/j.tics.2010.11.004 contributor: fullname: Kalisch – volume: 2 start-page: 198 year: 2015 end-page: 208 ident: CR60 article-title: Novel Glutamatergic Treatments for Severe Mood Disorders publication-title: Curr. Behav. Neurosci. Reports doi: 10.1007/s40473-015-0050-5 contributor: fullname: Zarate – volume: 76 start-page: 689 year: 1996 end-page: 706 ident: CR33 article-title: The course of neural projection from the prefrontal cortex to the nucleus accumbens in the rat publication-title: Neuroscience doi: 10.1016/S0306-4522(96)00380-6 contributor: fullname: Yang – volume: 17 start-page: 1547 year: 2013 end-page: 57 ident: CR7 article-title: Psychiatric co-morbidities in patients with chronic peripheral neuropathic pain: a multicentre cohort study publication-title: Eur. J. Pain contributor: fullname: Attal – volume: 757 start-page: 11 year: 2015 end-page: 20 ident: CR56 article-title: DSR-98776, a novel selective mGlu5 receptor negative allosteric modulator with potent antidepressant and antimanic activity publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2015.03.024 contributor: fullname: Kato – volume: 50 start-page: 355 year: 1992 end-page: 363 ident: CR23 article-title: An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat publication-title: Pain doi: 10.1016/0304-3959(92)90041-9 contributor: fullname: Mo Chung – volume: 75 start-page: 997 year: 2008 end-page: 1006 ident: CR52 article-title: Mood disorders: regulation by metabotropic glutamate receptors publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2007.09.021 contributor: fullname: Witkin – volume: 126 start-page: 1983 year: 2016 end-page: 1997 ident: CR14 article-title: Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain publication-title: J. Clin. Invest. doi: 10.1172/JCI82859 contributor: fullname: Kim – volume: 12 start-page: 752 year: 2015 end-page: 759 ident: CR31 article-title: Role of Prelimbic GABAergic Circuits in Sensory and Emotional Aspects of Neuropathic Pain publication-title: Cell Rep. doi: 10.1016/j.celrep.2015.07.001 contributor: fullname: Zhang – volume: 195 start-page: 200 year: 2011 end-page: 205 ident: CR65 article-title: Repeated rat-forced swim test: Reducing the number of animals to evaluate gradual effects of antidepressants publication-title: J. Neurosci. Methods doi: 10.1016/j.jneumeth.2010.12.015 contributor: fullname: Lino-de-Oliveira – ident: CR32 – volume: 66 start-page: 202 year: 2013 end-page: 214 ident: CR57 article-title: Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2012.04.007 contributor: fullname: Hughes – volume: 77 start-page: 285 year: 2015 end-page: 294 ident: CR25 article-title: Illness progression, recent stress, and morphometry of hippocampal subfields and medial prefrontal cortex in major depression publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2014.06.018 contributor: fullname: Treadway – volume: 353 start-page: 213 year: 2015 end-page: 233 ident: CR59 article-title: Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression publication-title: J. Pharmacol. Exp. Ther. doi: 10.1124/jpet.114.222463 contributor: fullname: Lindemann – volume: 30 start-page: 1 year: 2015 end-page: 21 ident: CR13 article-title: Animal models for the study of comorbid pain and psychiatric disorders publication-title: Mod. Trends Pharmacopsychiatry doi: 10.1159/000435929 contributor: fullname: Almeida – volume: 47 start-page: 1007 year: 2009 end-page: 1014 ident: CR5 article-title: MRI structural brain changes associated with sensory and emotional function in a rat model of long-term neuropathic pain publication-title: Neuroimage doi: 10.1016/j.neuroimage.2009.05.068 contributor: fullname: Seminowicz – volume: 53 start-page: 55 year: 1994 end-page: 63 ident: CR62 article-title: Quantitative assessment of tactile allodynia in the rat paw publication-title: J. Neurosci. Methods doi: 10.1016/0165-0270(94)90144-9 contributor: fullname: Yaksh – volume: 168 start-page: 727 year: 2011 end-page: 734 ident: CR46 article-title: Reduced metabotropic glutamate receptor 5 density in major depression determined by [11C]ABP688 PET and postmortem study publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2011.09111607 contributor: fullname: Deschwanden – volume: 7 start-page: 1009 year: 2012 end-page: 1014 ident: CR64 article-title: a & Cryan, J. F. Using the rat forced swim test to assess antidepressant-like activity in rodents publication-title: Nat. Protoc. doi: 10.1038/nprot.2012.044 contributor: fullname: Slattery – volume: 29 start-page: 2684 year: 2009 end-page: 94 ident: CR39 article-title: Roles of the insular cortex in the modulation of pain: insights from brain lesions publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5173-08.2009 contributor: fullname: Starr – volume: 85 start-page: S42 year: 2010 end-page: 50 ident: CR9 article-title: Assessment and treatment of psychosocial comorbidities in patients with neuropathic pain publication-title: Mayo Clin. Proc. doi: 10.4065/mcp.2009.0648 contributor: fullname: Stanos – year: 2017 ident: CR49 article-title: Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study publication-title: Biol. Psychiatry Cogn. Neurosci. Neuroimaging doi: 10.1016/j.bpsc.2017.03.019 contributor: fullname: Abdallah – volume: 155 start-page: 1128 issue: 6 year: 2014 end-page: 1139 ident: CR40 article-title: Role of nucleus accumbens in neuropathic pain: Linked multi-scale evidence in the rat transitioning to neuropathic pain publication-title: Pain doi: 10.1016/j.pain.2014.02.019 contributor: fullname: Apkarian – volume: 43 start-page: 168 year: 2013 end-page: 184 ident: CR17 article-title: Synaptic plasticity in depression: Molecular, cellular and functional correlates publication-title: Progress in Neuro-Psychopharmacology and Biological Psychiatry doi: 10.1016/j.pnpbp.2012.12.012 contributor: fullname: Marsden – volume: 115 start-page: 116 year: 2007 end-page: 147 ident: CR53 article-title: Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2007.04.007 contributor: fullname: Pilc – volume: 104 start-page: 1570 year: 2007 end-page: 1577 ident: CR12 article-title: Experimental neuropathy in mice is associated with delayed behavioral changes related to anxiety and depression publication-title: Anesth. Analg. doi: 10.1213/01.ane.0000261514.19946.66 contributor: fullname: Suzuki – volume: 35 start-page: 13244 year: 2015 end-page: 56 ident: CR15 article-title: Peripheral Neuropathy Induces HCN Channel Dysfunction in Pyramidal Neurons of the Medial Prefrontal Cortex publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0799-15.2015 contributor: fullname: Seguela – volume: 24 start-page: 1247 year: 2015 end-page: 1260 ident: CR55 article-title: Basimglurant for treatment of major depressive disorder: a novel negative allosteric modulator of metabotropic glutamate receptor 5 publication-title: Expert Opin. Investig. Drugs doi: 10.1517/13543784.2015.1074175 contributor: fullname: Borroto-Escuela – volume: 20 start-page: 1546 year: 2015 end-page: 1556 ident: CR29 article-title: Alteration by p11 of mGluR5 localization regulates depression-like behaviors publication-title: Mol. Psychiatry doi: 10.1038/mp.2015.132 contributor: fullname: Lee – volume: 26 start-page: 12165 year: 2006 end-page: 73 ident: CR22 article-title: Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3576-06.2006 contributor: fullname: Baliki – volume: 22 start-page: 238 year: 2016 end-page: 249 ident: CR18 article-title: Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants publication-title: Nat. Med. doi: 10.1038/nm.4050 contributor: fullname: Krystal – volume: 87 start-page: 1720 year: 2016 end-page: 1726 ident: CR43 article-title: Involvement of the nucleus accumbens and dopamine system in chronic pain publication-title: Neurology doi: 10.1212/WNL.0000000000003243 contributor: fullname: Benarroch – volume: 60 start-page: 967 year: 1965 end-page: 978 ident: CR61 article-title: The up-and-down method for small samples publication-title: J. Am. Stat. Assoc. doi: 10.1080/01621459.1965.10480843 contributor: fullname: Dixon – volume: 301 start-page: 363 year: 2015 end-page: 374 ident: CR50 article-title: Prenatal chronic mild stress induces depression-like behavior and sex-specific changes in regional glutamate receptor expression patterns in adult rats publication-title: Neuroscience doi: 10.1016/j.neuroscience.2015.06.008 contributor: fullname: Wang – ident: CR38 – volume: 66 start-page: 40 year: 2013 end-page: 52 ident: CR58 article-title: mGlu2/3 and mGlu5 receptors: Potential targets for novel antidepressants publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2012.05.022 contributor: fullname: Pilc – volume: 14 start-page: 1338 year: 2012 end-page: 1344 ident: CR26 article-title: Medial Prefrontal Cortex as an action-outcome predictor publication-title: Nat. Neurosci. doi: 10.1038/nn.2921 contributor: fullname: Brown – volume: 20 start-page: 1057 year: 2015 end-page: 1068 ident: CR48 article-title: Sex differences in glutamate receptor gene expression in major depression and suicide publication-title: Mol. Psychiatry doi: 10.1038/mp.2015.91 contributor: fullname: Sodhi – volume: 12 start-page: 1364 year: 2009 end-page: 1366 ident: CR66 article-title: Unmasking the tonic-aversive state in neuropathic pain publication-title: Nat. Neurosci. doi: 10.1038/nn.2407 contributor: fullname: King – volume: 66 start-page: 375 year: 2009 end-page: 390 ident: CR3 article-title: Central mechanisms of experimental and chronic neuropathic pain: Findings from functional imaging studies publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-008-8428-0 contributor: fullname: Maihöfner – volume: 91 start-page: 344 year: 2014 end-page: 352 ident: CR6 article-title: NeuroImage Metabolic brain activity suggestive of persistent pain in a rat model of neuropathic pain publication-title: Neuroimage doi: 10.1016/j.neuroimage.2014.01.020 contributor: fullname: Thompson – volume: 18 start-page: 1017 year: 2015 end-page: 1024 ident: CR67 article-title: mGluR5 in the nucleus accumbens is critical for promoting resilience to chronic stress publication-title: Nat. Neurosci. doi: 10.1038/nn.4028 contributor: fullname: Shin – volume: 15 start-page: 181 year: 2014 end-page: 92 ident: CR19 article-title: Hippocampal synaptic plasticity, spatial memory and anxiety publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3677 contributor: fullname: Bannerman – volume: 10 start-page: 1 year: 2016 end-page: 12 ident: CR44 article-title: Reduced Glutamatergic Currents and Dendritic Branching of Layer 5 Pyramidal Cells Contribute to Medial Prefrontal Cortex Deactivation in a Rat Model of Neuropathic Pain publication-title: Front. Cell. Neurosci. contributor: fullname: Martina – ident: CR24 – volume: 42 start-page: 844 year: 2017 end-page: 853 ident: CR42 article-title: Dysfunction of Nucleus Accumbens Is Associated With Psychiatric Problems in Patients With Chronic Low Back Pain publication-title: Spine (Phila. Pa. 1976). doi: 10.1097/BRS.0000000000001930 contributor: fullname: Kaneko – year: 2017 ident: CR45 article-title: Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression publication-title: Mol. Psychiatry doi: 10.1038/mp.2017.58 contributor: fullname: Esterlis – volume: 35 start-page: 13244 year: 2015 ident: 9991_CR15 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0799-15.2015 contributor: fullname: SC Matos – volume: 276 start-page: 92 year: 2015 ident: 9991_CR11 publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2014.04.042 contributor: fullname: JX Li – volume: 47 start-page: 154 year: 2014 ident: 9991_CR21 publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2014.08.002 contributor: fullname: I Yalcin – volume: 115 start-page: 116 year: 2007 ident: 9991_CR53 publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2007.04.007 contributor: fullname: A Palucha – volume: 17 start-page: 1547 year: 2013 ident: 9991_CR7 publication-title: Eur. J. Pain doi: 10.1002/j.1532-2149.2013.00334.x contributor: fullname: F Radat – volume: 353 start-page: 213 year: 2015 ident: 9991_CR59 publication-title: J. Pharmacol. Exp. Ther. doi: 10.1124/jpet.114.222463 contributor: fullname: L Lindemann – volume: 106 start-page: 2423 year: 2009 ident: 9991_CR2 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0809897106 contributor: fullname: AE Metz – volume: 76 start-page: 689 year: 1996 ident: 9991_CR33 publication-title: Neuroscience doi: 10.1016/S0306-4522(96)00380-6 contributor: fullname: N Gorelova – volume: 77 start-page: 285 year: 2015 ident: 9991_CR25 publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2014.06.018 contributor: fullname: MT Treadway – volume: 43 start-page: 168 year: 2013 ident: 9991_CR17 publication-title: Progress in Neuro-Psychopharmacology and Biological Psychiatry doi: 10.1016/j.pnpbp.2012.12.012 contributor: fullname: WN Marsden – volume: 66 start-page: 202 year: 2013 ident: 9991_CR57 publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2012.04.007 contributor: fullname: ZA Hughes – volume: 51 start-page: 32 year: 2004 ident: 9991_CR34 publication-title: Synapse doi: 10.1002/syn.10279 contributor: fullname: RP Vertes – volume: 20 start-page: 1057 year: 2015 ident: 9991_CR48 publication-title: Mol. Psychiatry doi: 10.1038/mp.2015.91 contributor: fullname: AL Gray – volume: 42 start-page: 844 year: 2017 ident: 9991_CR42 publication-title: Spine (Phila. Pa. 1976). doi: 10.1097/BRS.0000000000001930 contributor: fullname: H Kaneko – volume: 87 start-page: 1720 year: 2016 ident: 9991_CR43 publication-title: Neurology doi: 10.1212/WNL.0000000000003243 contributor: fullname: EE Benarroch – volume: 53 start-page: 55 year: 1994 ident: 9991_CR62 publication-title: J. Neurosci. Methods doi: 10.1016/0165-0270(94)90144-9 contributor: fullname: SR Chaplan – ident: 9991_CR35 doi: 10.1523/ENEURO.0002-16.2016 – volume: 20 start-page: 1546 year: 2015 ident: 9991_CR29 publication-title: Mol. Psychiatry doi: 10.1038/mp.2015.132 contributor: fullname: K-W Lee – volume: 168 start-page: 727 year: 2011 ident: 9991_CR46 publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2011.09111607 contributor: fullname: A Deschwanden – volume: 195 start-page: 200 year: 2011 ident: 9991_CR65 publication-title: J. Neurosci. Methods doi: 10.1016/j.jneumeth.2010.12.015 contributor: fullname: TJ Mezadri – volume: 31 start-page: 199 year: 2008 ident: 9991_CR1 publication-title: Trends Neurosci. doi: 10.1016/j.tins.2008.01.003 contributor: fullname: M Zhuo – volume: 757 start-page: 11 year: 2015 ident: 9991_CR56 publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2015.03.024 contributor: fullname: T Kato – volume: 60 start-page: 967 year: 1965 ident: 9991_CR61 publication-title: J. Am. Stat. Assoc. doi: 10.1080/01621459.1965.10480843 contributor: fullname: WJ Dixon – year: 2017 ident: 9991_CR49 publication-title: Biol. Psychiatry Cogn. Neurosci. Neuroimaging doi: 10.1016/j.bpsc.2017.03.019 contributor: fullname: CG Abdallah – volume: 30 start-page: 1 year: 2015 ident: 9991_CR13 publication-title: Mod. Trends Pharmacopsychiatry doi: 10.1159/000435929 contributor: fullname: H Leite-Almeida – volume: 155 start-page: 1128 issue: 6 year: 2014 ident: 9991_CR40 publication-title: Pain doi: 10.1016/j.pain.2014.02.019 contributor: fullname: Pei-Ching Chang – volume: 104 start-page: 1570 year: 2007 ident: 9991_CR12 publication-title: Anesth. Analg. doi: 10.1213/01.ane.0000261514.19946.66 contributor: fullname: T Suzuki – volume: 18 start-page: 1017 year: 2015 ident: 9991_CR67 publication-title: Nat. Neurosci. doi: 10.1038/nn.4028 contributor: fullname: S Shin – volume: 14 start-page: 502 year: 2013 ident: 9991_CR20 publication-title: Nat Rev Neurosci doi: 10.1038/nrn3516 contributor: fullname: MC Bushnell – volume: 10 start-page: 1 year: 2016 ident: 9991_CR44 publication-title: Front. Cell. Neurosci. contributor: fullname: CJ Kelly – ident: 9991_CR32 doi: 10.1016/S0301-0082(98)00095-1 – volume: 46 start-page: 666 year: 2007 ident: 9991_CR8 publication-title: Rheumatology doi: 10.1093/rheumatology/kel363 contributor: fullname: A Gupta – volume: 290 start-page: 213 year: 1989 ident: 9991_CR36 publication-title: J. Comp. Neurol. doi: 10.1002/cne.902900205 contributor: fullname: SR Sesack – volume: 84 start-page: 778 year: 2015 ident: 9991_CR37 publication-title: Nat. Neurosci. contributor: fullname: MB Hoppa – volume: 66 start-page: 375 year: 2009 ident: 9991_CR3 publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-008-8428-0 contributor: fullname: F Seifert – volume: 263 start-page: 367 year: 2013 ident: 9991_CR54 publication-title: Eur. Arch. Psychiatry Clin. Neurosci. doi: 10.1007/s00406-013-0399-y contributor: fullname: K Hashimoto – volume: 6 year: 2015 ident: 9991_CR30 publication-title: Nat. Commun. doi: 10.1038/ncomms8660 contributor: fullname: G-Q Wang – volume: 64 start-page: 1175 year: 2005 ident: 9991_CR41 publication-title: Neurology doi: 10.1212/01.WNL.0000156353.17305.52 contributor: fullname: M Schreckenberger – volume: 2 start-page: 198 year: 2015 ident: 9991_CR60 publication-title: Curr. Behav. Neurosci. Reports doi: 10.1007/s40473-015-0050-5 contributor: fullname: M Park – volume: 26 start-page: 12165 year: 2006 ident: 9991_CR22 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3576-06.2006 contributor: fullname: MN Baliki – volume: 126 start-page: 1983 year: 2016 ident: 9991_CR14 publication-title: J. Clin. Invest. doi: 10.1172/JCI82859 contributor: fullname: SK Kim – volume: 22 start-page: 238 year: 2016 ident: 9991_CR18 publication-title: Nat. Med. doi: 10.1038/nm.4050 contributor: fullname: RS Duman – volume: 301 start-page: 363 year: 2015 ident: 9991_CR50 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2015.06.008 contributor: fullname: Y Wang – volume: 1353 start-page: 225 year: 2010 ident: 9991_CR10 publication-title: Brain Res. doi: 10.1016/j.brainres.2010.07.023 contributor: fullname: M Shi – volume: 129 start-page: 105 year: 2003 ident: 9991_CR63 publication-title: J. Neurosci. Methods doi: 10.1016/S0165-0270(03)00192-4 contributor: fullname: P Schweinhardt – volume: 15 start-page: 181 year: 2014 ident: 9991_CR19 publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3677 contributor: fullname: DM Bannerman – volume: 91 start-page: 344 year: 2014 ident: 9991_CR6 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2014.01.020 contributor: fullname: SJ Thompson – ident: 9991_CR24 doi: 10.1016/j.jad.2010.11.034 – volume: 7 start-page: 1009 year: 2012 ident: 9991_CR64 publication-title: Nat. Protoc. doi: 10.1038/nprot.2012.044 contributor: fullname: D Slattery – volume: 66 start-page: 40 year: 2013 ident: 9991_CR58 publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2012.05.022 contributor: fullname: S Chaki – volume: 75 start-page: 997 year: 2008 ident: 9991_CR52 publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2007.09.021 contributor: fullname: A Pilc – volume: 50 start-page: 355 year: 1992 ident: 9991_CR23 publication-title: Pain doi: 10.1016/0304-3959(92)90041-9 contributor: fullname: S Ho Kim – volume: 37 start-page: 2428 year: 2012 ident: 9991_CR27 publication-title: Neuropsychopharmacology doi: 10.1038/npp.2012.101 contributor: fullname: AM McEwen – volume: 14 start-page: 1338 year: 2012 ident: 9991_CR26 publication-title: Nat. Neurosci. doi: 10.1038/nn.2921 contributor: fullname: WH Alexander – year: 2017 ident: 9991_CR45 publication-title: Mol. Psychiatry doi: 10.1038/mp.2017.58 contributor: fullname: I Esterlis – volume: 6 start-page: 87 year: 2007 ident: 9991_CR51 publication-title: CNS Neurol Disord Drug Targets doi: 10.2174/187152707780363302 contributor: fullname: JM Witkin – volume: 12 start-page: 1364 year: 2009 ident: 9991_CR66 publication-title: Nat. Neurosci. doi: 10.1038/nn.2407 contributor: fullname: T King – volume: 85 start-page: S42 year: 2010 ident: 9991_CR9 publication-title: Mayo Clin. Proc. doi: 10.4065/mcp.2009.0648 contributor: fullname: DC Turk – ident: 9991_CR16 doi: 10.1016/bs.pmbts.2014.12.003 – volume: 15 start-page: 85 year: 2011 ident: 9991_CR28 publication-title: Trends in Cognitive Sciences doi: 10.1016/j.tics.2010.11.004 contributor: fullname: A Etkin – ident: 9991_CR38 doi: 10.1126/science.1253994 – volume: 12 start-page: 752 year: 2015 ident: 9991_CR31 publication-title: Cell Rep. doi: 10.1016/j.celrep.2015.07.001 contributor: fullname: Z Zhang – volume: 29 start-page: 2684 year: 2009 ident: 9991_CR39 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5173-08.2009 contributor: fullname: CJ Starr – volume: 47 start-page: 1007 year: 2009 ident: 9991_CR5 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2009.05.068 contributor: fullname: DA Seminowicz – volume: 114 start-page: 93 year: 2005 ident: 9991_CR4 publication-title: Pain doi: 10.1016/j.pain.2004.12.001 contributor: fullname: C Maihöfner – volume: 24 start-page: 1247 year: 2015 ident: 9991_CR55 publication-title: Expert Opin. Investig. Drugs doi: 10.1517/13543784.2015.1074175 contributor: fullname: K Fuxe – volume: 5 year: 2015 ident: 9991_CR47 publication-title: Transl. Psychiatry doi: 10.1038/tp.2015.189 contributor: fullname: C DeLorenzo |
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Snippet | Patients with chronic pain easily accompany the negative mood symptoms such as depression and anxiety, and these disturbances in turn affect the aversive... Abstract Patients with chronic pain easily accompany the negative mood symptoms such as depression and anxiety, and these disturbances in turn affect the... |
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SubjectTerms | 631/378/1457/1945 631/378/1689/1414 631/378/1689/2610 692/699/375/1692 692/699/476/1414 Affect Animals Anxiety Chronic pain Comorbidity Disease Models, Animal Emotions Glutamic acid receptors (metabotropic) Humanities and Social Sciences Hypersensitivity Mental depression Mood multidisciplinary Neuralgia Neuralgia - physiopathology Pain Pain Perception Positron emission tomography Prefrontal cortex Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - physiology Radioactive tracers Rats Receptor, Metabotropic Glutamate 5 - biosynthesis Rodents Science Science (multidisciplinary) Spinal cord Spinal Nerves Up-Regulation Wounds and Injuries |
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Title | Upregulation of prefrontal metabotropic glutamate receptor 5 mediates neuropathic pain and negative mood symptoms after spinal nerve injury in rats |
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