Pharmacokinetics and bioavailability study of two ondansetron oral soluble film formulations in fasting healthy male Chinese volunteers - Zhang, Qian; Jianjun, Zou; Meng, Wan; Zheng, Zhao; Junrong, Zhu; Yubing, Zhu (Drug design, development and therapy, 2015)
Keywords: Administration, Oral; Adolescent; Adult; Antiemetics - administration & dosage; Antiemetics - blood; Antiemetics - pharmacokinetics; Area Under Curve; Asian Continental Ancestry Group; Bioavailability; bioequivalence; Biological Availability; Blood; Chemistry, Pharmaceutical; China; Chromatography; Chromatography, High Pressure Liquid; Clinical medicine; Comparative analysis; Confidence intervals; Controlled release technology; Cross-Over Studies; Dosage and administration; Dosage Forms; Drug administration; Drug dosages; Drug metabolism; Fasting; FDA approval; Food; Formulations; Gastrointestinal Absorption; Genetic transformation; Half-Life; Healthy Volunteers; Hematology; Humans; International conferences; Laboratories; Laboratory tests; LC-MS/MS; Male; Mass spectrometry; Metabolic Clearance Rate; Nausea; Ondansetron; Ondansetron - administration & dosage; Ondansetron - blood; Ondansetron - pharmacokinetics; oral soluble film; Original Research; Pharmaceuticals; Pharmacokinetics; Pharmacology; Regulatory approval; Scientific imaging; Serotonin Antagonists - administration & dosage; Serotonin Antagonists - blood; Serotonin Antagonists - pharmacokinetics; Statistical analysis; Statistical methods; Swallowing; Tandem Mass Spectrometry; Testing; Therapeutic Equivalency; Urinalysis; Variance analysis; Vomiting; Young Adult; China; United States--US; LC-MS/MS; oral soluble film; ondansetron; bioequivalence