A circuit from lateral septum neurotensin neurons to tuberal nucleus controls hedonic feeding

• Published in: Molecular psychiatry Vol. 27; no. 12; pp. 4843 - 4860
• Main Authors: Chen, Zijun, Chen, Gaowei, Zhong, Jiafeng, Jiang, Shaolei, Lai, Shishi, Xu, Hua, Deng, Xiaofei, Li, Fengling, Lu, Shanshan, Zhou, Kuikui, Li, Changlin, Liu, Zhongdong, Zhang, Xu, Zhu, Yingjie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2022; Nature Publishing Group
• Subjects: 13/51; 14/32; 631/378; 631/443; 64/60; 9/74; Animal cognition; Animals; Behavioral Sciences; Biological Psychology; Brain diseases; Brain research; Calcium imaging; Dopamine; Experiments; Feeding behavior; Feeding Behavior - physiology; Food; Food consumption; Genetic engineering; Hedonic response; High fat diet; Hypothalamic Area, Lateral - physiology; Laboratory animals; Medicine; Medicine & Public Health; Metabolic disorders; Mice; Neural networks; Neurons; Neurons - metabolism; Neurosciences; Neurotensin; Neurotensin - metabolism; Obesity; Obesity - metabolism; Pharmacotherapy; Psychiatry; Science; Septum; γ-Aminobutyric acid

Feeding behavior is regulated by both the homeostatic needs of the body and hedonic values of the food. Easy access to palatable energy-dense foods and the consequent obesity epidemic stress the urgent need for a better understanding of neural circuits that regulate hedonic feeding. Here, we report...