Multiscale bone quality analysis in osteoarthritic knee joints reveal a role of the mechanosensory osteocyte network in osteophytes

• Published in: Scientific reports Vol. 10; no. 1; p. 673
• Main Authors: Rabelo, Gustavo Davi, vom Scheidt, Annika, Klebig, Felix, Hemmatian, Haniyeh, Citak, Mustafa, Amling, Michael, Busse, Björn, Jähn, Katharina
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.01.2020; Nature Publishing Group
• Subjects: 14; 14/63; 631/443/63; 692/699; Arthritis; Biomechanical Phenomena; Bone and Bones - pathology; Bone and Bones - physiology; Bone Density; Bone growth; Bone mineral density; Cancellous bone; Cartilage; Collagen; Humanities and Social Sciences; Humans; Knee Joint - metabolism; Knee Joint - pathology; Lamellar bone; multidisciplinary; Osteoarthritis; Osteoarthritis, Knee - metabolism; Osteoarthritis, Knee - pathology; Osteocytes; Osteocytes - pathology; Osteocytes - physiology; Osteogenesis; Osteophyte - etiology; Osteophyte - metabolism; Osteophyte - pathology; Osteophyte - physiopathology; Osteophytes; Physiology; Science; Science (multidisciplinary); Subchondral bone

Osteophytes - bony outgrowths on joint structures - are found in healthy individuals but are specifically present in late osteoarthritis (OA). Osteophyte development and function is not well understood, yet biomechanical stimuli are thought to be critical. Bone adapts to mechanical forces via the ce...