Opportunities for a probabilistic risk assessment of chemicals in the European Union

In risk assessment of new and existing substances, it is current practice to characterise risk using a deterministic quotient of the exposure concentration, or the dose, and a no-effect level. A sense of uncertainty is tackled by introducing worst-case assumptions in the methodology. Since this proc...

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Published inChemosphere (Oxford) Vol. 43; no. 2; pp. 257 - 264
Main Authors Jager, Tjalling, Vermeire, Theo G, Rikken, Mathieu G.J, van der Poel, Paul
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.04.2001
Elsevier
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Abstract In risk assessment of new and existing substances, it is current practice to characterise risk using a deterministic quotient of the exposure concentration, or the dose, and a no-effect level. A sense of uncertainty is tackled by introducing worst-case assumptions in the methodology. Since this procedure leads to an assessment with an unknown degree of conservatism, it is advisable to deal quantitatively with uncertainties. This paper discusses the advantages and possibilities of a probabilistic risk assessment framework, illustrated with an example calculation. Furthermore, representatives of EU Member States and the chemical industry were interviewed to find out their views on applying uncertainty analysis to risk assessment of industrial chemicals.
AbstractList In risk assessment of new and existing substances, it is current practice to characterise risk using a deterministic quotient of the exposure concentration, or the dose, and a no-effect level. A sense of uncertainty is tackled by introducing worst-case assumptions in the methodology. Since this procedure leads to an assessment with an unknown degree of conservatism, it is advisable to deal quantitatively with uncertainties. This paper discusses the advantages and possibilities of a probabilistic risk assessment framework, illustrated with an example calculation. Furthermore, representatives of EU Member States and the chemical industry were interviewed to find out their views on applying uncertainty analysis to risk assessment of industrial chemicals.
Author Vermeire, Theo G
Jager, Tjalling
Rikken, Mathieu G.J
van der Poel, Paul
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Issue 2
Keywords TGD
EUSES
Uncertainty analysis
Risk assessment
Uncertainty
Pollution
Health and environment
Ecotoxicology
Toxicity
European Union
Ecosystem
Environment impact
Dose equivalent
Risk analysis
Public health
Chemical product
Language English
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Elsevier
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Snippet In risk assessment of new and existing substances, it is current practice to characterise risk using a deterministic quotient of the exposure concentration, or...
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SubjectTerms Air. Soil. Water. Waste. Feeding
Animal, plant and microbial ecology
Applied ecology
Applied sciences
Biological and medical sciences
Ecotoxicology, biological effects of pollution
Environment. Living conditions
Environmental Exposure - standards
Environmental Exposure - statistics & numerical data
European Union
EUSES
Exact sciences and technology
Food Contamination
Fundamental and applied biological sciences. Psychology
General aspects
Global environmental pollution
Humans
Industrial Waste
International Cooperation
Medical sciences
Models, Statistical
No-Observed-Adverse-Effect Level
Pollution
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk assessment
Risk Assessment - legislation & jurisprudence
Risk Assessment - methods
Soil Pollutants
TGD
uncertainty
Uncertainty analysis
Water Pollution
Title Opportunities for a probabilistic risk assessment of chemicals in the European Union
URI https://dx.doi.org/10.1016/S0045-6535(00)00087-4
https://www.ncbi.nlm.nih.gov/pubmed/11297405
https://search.proquest.com/docview/18078635
Volume 43
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