Negative association between free triiodothyronine level and international normalized ratio in euthyroid subjects with acute myocardial infarction
Aim： To investigate the relationship between free triiodothyronine （FT3） and the international normalized ratio （the ratio of the prothrombin time of a patient to the normal sample, INR） in Chinese euthyroid subjects with acute ST-segment elevation myocardial infarction （STEMI）. Methods： A total of...
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| Published in | Acta pharmacologica Sinica Vol. 32; no. 11; pp. 1351 - 1356 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.11.2011
Nature Publishing Group |
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| Online Access | Get full text |
| ISSN | 1671-4083 1745-7254 1745-7254 |
| DOI | 10.1038/aps.2011.118 |
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| Abstract | Aim： To investigate the relationship between free triiodothyronine （FT3） and the international normalized ratio （the ratio of the prothrombin time of a patient to the normal sample, INR） in Chinese euthyroid subjects with acute ST-segment elevation myocardial infarction （STEMI）. Methods： A total of 235 consecutive patients （177 males, 54 females） with STEMI were enrolled. Anthropometric and laboratory mea- surements, including heart rate, respiratory rate, blood pressure, body temperature, platelet count, INR, prothrombin time, activated partial thromboplastin time, FT3, free thyroxine （FT4）, and thyroid-stimulating hormone, were collected from all the patients. The levels of FT3 and FT4 were measured with a full-automatic immune analyzer. The INR was determined using a coagulation analyzer. Results： Patients were classified into 4 groups according to their quartile FT3 and FT4 levels： 0.40-3.09 （n=52）, 3.$0-3.69 （n=56）, 3.70-439 （n=64） and 4.30-7.10 （n=59） for FT3; 4.9-14.8 （n=57）, $4.9-16.8 （n=58）, 16.9-18.7 （n=57） and 18.8-29.0 （n=59） for FT4. Subjects with a high FT3 level had significantly lower values of INR than those with a low FT3 level （P=0.01）. Multiple linear regression analysis revealed decreased serum FT3 as an independent risk factor for elevated INR values （β=-0.139, P=0.025）. The value of INR was similar among the 4 groups according to the quartile FT4 levels （P=0.36）. Conclusion： Free triiodothyronine was negatively associated with INR in the patients with acute STEMI and normal thyroid function. |
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| AbstractList | Aim： To investigate the relationship between free triiodothyronine （FT3） and the international normalized ratio （the ratio of the prothrombin time of a patient to the normal sample, INR） in Chinese euthyroid subjects with acute ST-segment elevation myocardial infarction （STEMI）. Methods： A total of 235 consecutive patients （177 males, 54 females） with STEMI were enrolled. Anthropometric and laboratory mea- surements, including heart rate, respiratory rate, blood pressure, body temperature, platelet count, INR, prothrombin time, activated partial thromboplastin time, FT3, free thyroxine （FT4）, and thyroid-stimulating hormone, were collected from all the patients. The levels of FT3 and FT4 were measured with a full-automatic immune analyzer. The INR was determined using a coagulation analyzer. Results： Patients were classified into 4 groups according to their quartile FT3 and FT4 levels： 0.40-3.09 （n=52）, 3.$0-3.69 （n=56）, 3.70-439 （n=64） and 4.30-7.10 （n=59） for FT3; 4.9-14.8 （n=57）, $4.9-16.8 （n=58）, 16.9-18.7 （n=57） and 18.8-29.0 （n=59） for FT4. Subjects with a high FT3 level had significantly lower values of INR than those with a low FT3 level （P=0.01）. Multiple linear regression analysis revealed decreased serum FT3 as an independent risk factor for elevated INR values （β=-0.139, P=0.025）. The value of INR was similar among the 4 groups according to the quartile FT4 levels （P=0.36）. Conclusion： Free triiodothyronine was negatively associated with INR in the patients with acute STEMI and normal thyroid function. To investigate the relationship between free triiodothyronine (FT3) and the international normalized ratio (the ratio of the prothrombin time of a patient to the normal sample, INR) in Chinese euthyroid subjects with acute ST-segment elevation myocardial infarction (STEMI). A total of 231 consecutive patients (177 males, 54 females) with STEMI were enrolled. Anthropometric and laboratory measurements, including heart rate, respiratory rate, blood pressure, body temperature, platelet count, INR, prothrombin time, activated partial thromboplastin time, FT3, free thyroxine (FT4), and thyroid-stimulating hormone, were collected from all the patients. The levels of FT3 and FT4 were measured with a full-automatic immune analyzer. The INR was determined using a coagulation analyzer. Patients were classified into 4 groups according to their quartile FT3 and FT4 levels: 0.40-3.09 (n=52), 3.10-3.69 (n=56), 3.70-4.29 (n=64) and 4.30-7.10 (n=59) for FT3; 4.9-14.8 (n=57), 14.9-16.8 (n=58), 16.9-18.7 (n=57) and 18.8-29.0 (n=59) for FT4. Subjects with a high FT3 level had significantly lower values of INR than those with a low FT3 level (P=0.01). Multiple linear regression analysis revealed decreased serum FT3 as an independent risk factor for elevated INR values ([beta]=-0.139, P=0.025). The value of INR was similar among the 4 groups according to the quartile FT4 levels (P=0.36). Free triiodothyronine was negatively associated with INR in the patients with acute STEMI and normal thyroid function. Aim: To investigate the relationship between free triiodothyronine (FT3) and the international normalized ratio (the ratio of the prothrombin time of a patient to the normal sample, INR) in Chinese euthyroid subjects with acute ST-segment elevation myocardial infarction (STEMI). Methods: A total of 231 consecutive patients (177 males, 54 females) with STEMI were enrolled. Anthropometric and laboratory measurements, including heart rate, respiratory rate, blood pressure, body temperature, platelet count, INR, prothrombin time, activated partial thromboplastin time, FT3, free thyroxine (FT4), and thyroid-stimulating hormone, were collected from all the patients. The levels of FT3 and FT4 were measured with a full-automatic immune analyzer. The INR was determined using a coagulation analyzer. Results: Patients were classified into 4 groups according to their quartile FT3 and FT4 levels: 0.40–3.09 ( n =52), 3.10–3.69 ( n =56), 3.70–4.29 ( n =64) and 4.30–7.10 ( n =59) for FT3; 4.9–14.8 ( n =57), 14.9–16.8 ( n =58), 16.9–18.7 ( n =57) and 18.8–29.0 ( n =59) for FT4. Subjects with a high FT3 level had significantly lower values of INR than those with a low FT3 level ( P =0.01). Multiple linear regression analysis revealed decreased serum FT3 as an independent risk factor for elevated INR values (β=-0.139, P =0.025). The value of INR was similar among the 4 groups according to the quartile FT4 levels ( P =0.36). Conclusion: Free triiodothyronine was negatively associated with INR in the patients with acute STEMI and normal thyroid function. To investigate the relationship between free triiodothyronine (FT3) and the international normalized ratio (the ratio of the prothrombin time of a patient to the normal sample, INR) in Chinese euthyroid subjects with acute ST-segment elevation myocardial infarction (STEMI).AIMTo investigate the relationship between free triiodothyronine (FT3) and the international normalized ratio (the ratio of the prothrombin time of a patient to the normal sample, INR) in Chinese euthyroid subjects with acute ST-segment elevation myocardial infarction (STEMI).A total of 231 consecutive patients (177 males, 54 females) with STEMI were enrolled. Anthropometric and laboratory measurements, including heart rate, respiratory rate, blood pressure, body temperature, platelet count, INR, prothrombin time, activated partial thromboplastin time, FT3, free thyroxine (FT4), and thyroid-stimulating hormone, were collected from all the patients. The levels of FT3 and FT4 were measured with a full-automatic immune analyzer. The INR was determined using a coagulation analyzer.METHODSA total of 231 consecutive patients (177 males, 54 females) with STEMI were enrolled. Anthropometric and laboratory measurements, including heart rate, respiratory rate, blood pressure, body temperature, platelet count, INR, prothrombin time, activated partial thromboplastin time, FT3, free thyroxine (FT4), and thyroid-stimulating hormone, were collected from all the patients. The levels of FT3 and FT4 were measured with a full-automatic immune analyzer. The INR was determined using a coagulation analyzer.Patients were classified into 4 groups according to their quartile FT3 and FT4 levels: 0.40-3.09 (n=52), 3.10-3.69 (n=56), 3.70-4.29 (n=64) and 4.30-7.10 (n=59) for FT3; 4.9-14.8 (n=57), 14.9-16.8 (n=58), 16.9-18.7 (n=57) and 18.8-29.0 (n=59) for FT4. Subjects with a high FT3 level had significantly lower values of INR than those with a low FT3 level (P=0.01). Multiple linear regression analysis revealed decreased serum FT3 as an independent risk factor for elevated INR values (β=-0.139, P=0.025). The value of INR was similar among the 4 groups according to the quartile FT4 levels (P=0.36).RESULTSPatients were classified into 4 groups according to their quartile FT3 and FT4 levels: 0.40-3.09 (n=52), 3.10-3.69 (n=56), 3.70-4.29 (n=64) and 4.30-7.10 (n=59) for FT3; 4.9-14.8 (n=57), 14.9-16.8 (n=58), 16.9-18.7 (n=57) and 18.8-29.0 (n=59) for FT4. Subjects with a high FT3 level had significantly lower values of INR than those with a low FT3 level (P=0.01). Multiple linear regression analysis revealed decreased serum FT3 as an independent risk factor for elevated INR values (β=-0.139, P=0.025). The value of INR was similar among the 4 groups according to the quartile FT4 levels (P=0.36).Free triiodothyronine was negatively associated with INR in the patients with acute STEMI and normal thyroid function.CONCLUSIONFree triiodothyronine was negatively associated with INR in the patients with acute STEMI and normal thyroid function. To investigate the relationship between free triiodothyronine (FT3) and the international normalized ratio (the ratio of the prothrombin time of a patient to the normal sample, INR) in Chinese euthyroid subjects with acute ST-segment elevation myocardial infarction (STEMI). A total of 231 consecutive patients (177 males, 54 females) with STEMI were enrolled. Anthropometric and laboratory measurements, including heart rate, respiratory rate, blood pressure, body temperature, platelet count, INR, prothrombin time, activated partial thromboplastin time, FT3, free thyroxine (FT4), and thyroid-stimulating hormone, were collected from all the patients. The levels of FT3 and FT4 were measured with a full-automatic immune analyzer. The INR was determined using a coagulation analyzer. Patients were classified into 4 groups according to their quartile FT3 and FT4 levels: 0.40-3.09 (n=52), 3.10-3.69 (n=56), 3.70-4.29 (n=64) and 4.30-7.10 (n=59) for FT3; 4.9-14.8 (n=57), 14.9-16.8 (n=58), 16.9-18.7 (n=57) and 18.8-29.0 (n=59) for FT4. Subjects with a high FT3 level had significantly lower values of INR than those with a low FT3 level (P=0.01). Multiple linear regression analysis revealed decreased serum FT3 as an independent risk factor for elevated INR values (β=-0.139, P=0.025). The value of INR was similar among the 4 groups according to the quartile FT4 levels (P=0.36). Free triiodothyronine was negatively associated with INR in the patients with acute STEMI and normal thyroid function. |
| Author | Li LI Chang-yan GUO Jing YANG En-zhi JIA Tie-bing ZHU Lian-sheng WANG Ke-jiang CAO Wen-zhu MA Zhi-jian YANG |
| AuthorAffiliation | Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China First Clinical College of Nanjing Medical University, Nanjing 210029, China |
| Author_xml | – sequence: 1 givenname: Li surname: Li fullname: Li, Li organization: Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University – sequence: 2 givenname: Chang-yan surname: Guo fullname: Guo, Chang-yan organization: Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University – sequence: 3 givenname: Jing surname: Yang fullname: Yang, Jing organization: First Clinical College of Nanjing Medical University – sequence: 4 givenname: En-zhi surname: Jia fullname: Jia, En-zhi email: enzhijia@yahoo.cn organization: Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University – sequence: 5 givenname: Tie-bing surname: Zhu fullname: Zhu, Tie-bing organization: Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University – sequence: 6 givenname: Lian-sheng surname: Wang fullname: Wang, Lian-sheng organization: Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University – sequence: 7 givenname: Ke-jiang surname: Cao fullname: Cao, Ke-jiang organization: Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University – sequence: 8 givenname: Wen-zhu surname: Ma fullname: Ma, Wen-zhu organization: Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University – sequence: 9 givenname: Zhi-jian surname: Yang fullname: Yang, Zhi-jian organization: Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University |
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| Keywords | free triiodothyronine prothrombin time international normalized ratio acute ST elevation myocardial infarction Chinese euthyroid subject free thyroxine |
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| Notes | free triiodothyronine; free thyroxine; prothrombin time; international normalized ratio; acute ST elevation myocardial infarction; Chinese euthyroid subject Aim： To investigate the relationship between free triiodothyronine （FT3） and the international normalized ratio （the ratio of the prothrombin time of a patient to the normal sample, INR） in Chinese euthyroid subjects with acute ST-segment elevation myocardial infarction （STEMI）. Methods： A total of 235 consecutive patients （177 males, 54 females） with STEMI were enrolled. Anthropometric and laboratory mea- surements, including heart rate, respiratory rate, blood pressure, body temperature, platelet count, INR, prothrombin time, activated partial thromboplastin time, FT3, free thyroxine （FT4）, and thyroid-stimulating hormone, were collected from all the patients. The levels of FT3 and FT4 were measured with a full-automatic immune analyzer. The INR was determined using a coagulation analyzer. Results： Patients were classified into 4 groups according to their quartile FT3 and FT4 levels： 0.40-3.09 （n=52）, 3.$0-3.69 （n=56）, 3.70-439 （n=64） and 4.30-7.10 （n=59） for FT3; 4.9-14.8 （n=57）, $4.9-16.8 （n=58）, 16.9-18.7 （n=57） and 18.8-29.0 （n=59） for FT4. Subjects with a high FT3 level had significantly lower values of INR than those with a low FT3 level （P=0.01）. Multiple linear regression analysis revealed decreased serum FT3 as an independent risk factor for elevated INR values （β=-0.139, P=0.025）. The value of INR was similar among the 4 groups according to the quartile FT4 levels （P=0.36）. Conclusion： Free triiodothyronine was negatively associated with INR in the patients with acute STEMI and normal thyroid function. 31-1347/R ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 The first two authors contributed equally to this work. |
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| Snippet | Aim： To investigate the relationship between free triiodothyronine （FT3） and the international normalized ratio （the ratio of the prothrombin time of a patient... Aim: To investigate the relationship between free triiodothyronine (FT3) and the international normalized ratio (the ratio of the prothrombin time of a patient... To investigate the relationship between free triiodothyronine (FT3) and the international normalized ratio (the ratio of the prothrombin time of a patient to... |
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| SubjectTerms | Acute Disease Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine China - epidemiology Euthyroid Sick Syndromes - blood Euthyroid Sick Syndromes - complications Euthyroid Sick Syndromes - epidemiology Female FT3 Humans Immunology Internal Medicine International Normalized Ratio Male Medical Microbiology Middle Aged Myocardial Infarction - blood Myocardial Infarction - complications Myocardial Infarction - epidemiology Original original-article Pharmacology/Toxicology Prothrombin Time Thyroid Function Tests Thyroxine - blood Triiodothyronine - blood Vaccine 国际标准化 急性心肌梗死 比值 活化部分凝血活酶时间 游离 甲状腺功能 负相关 |
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| Title | Negative association between free triiodothyronine level and international normalized ratio in euthyroid subjects with acute myocardial infarction |
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