TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice

• Published in: Scientific reports Vol. 9; no. 1; p. 773
• Main Authors: Rode, Baptiste, Yuldasheva, Nadira Y., Baxter, Paul D., Sedo, Alicia, Ainscough, Justin F., Shires, Michael, Kearney, Mark T., Bailey, Marc A., Wheatcroft, Stephen B., Beech, David J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.01.2019; Nature Publishing Group
• Subjects: 13; 38; 631/443/592/75/2099; 64/110; 692/308/1426; Adiponectin; Adipose tissue; Animals; Aorta; Apolipoprotein E; Arteriosclerosis; Atherosclerosis; Body weight; Body weight gain; Calcium permeability; Coronary vessels; Diet; Diet, Western - adverse effects; Disease Models, Animal; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Genes, Dominant; Genetic Markers; Humanities and Social Sciences; Hypercholesterolemia - genetics; Inflammation; Interleukin 1; Interleukin 6; Leptin; Lipids; Lipogenesis; Male; Mice; Mice, Knockout, ApoE; Mice, Transgenic; Monocyte chemoattractant protein 1; multidisciplinary; Science; Science (multidisciplinary); Steatosis; Transcription; Transient receptor potential proteins; TRPC Cation Channels - genetics; Weight Gain - genetics

Transient Receptor Potential Canonical 5 (TRPC5) is a subunit of a Ca 2+ -permeable non-selective cationic channel which negatively regulates adiponectin but not leptin in mice fed chow diet. Adiponectin is a major anti-inflammatory mediator and so we hypothesized an effect of TRPC5 on the inflammat...