Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains

• Published in: Cell reports (Cambridge) Vol. 21; no. 10; pp. 2992 - 3002
• Main Authors: Joyce, M. Gordon, Georgiev, Ivelin S., Yang, Yongping, Druz, Aliaksandr, Geng, Hui, Chuang, Gwo-Yu, Kwon, Young Do, Pancera, Marie, Rawi, Reda, Sastry, Mallika, Stewart-Jones, Guillaume B.E., Zheng, Angela, Zhou, Tongqing, Choe, Misook, Van Galen, Joseph G., Chen, Rita E., Lees, Christopher R., Narpala, Sandeep, Chambers, Michael, Tsybovsky, Yaroslav, Baxa, Ulrich, McDermott, Adrian B., Mascola, John R., Kwong, Peter D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.12.2017; Elsevier
• Subjects: AIDS Vaccines - immunology; conformational stabilization; env Gene Products, Human Immunodeficiency Virus - immunology; env Gene Products, Human Immunodeficiency Virus - metabolism; envelope trimer; Enzyme-Linked Immunosorbent Assay; HIV-1 - immunology; HIV-1 - metabolism; HIV-1 vaccine; Microscopy, Electron; prefusion closed trimer; structure-based design; prefusion closed trimer; HIV-1 vaccine; envelope trimer; conformational stabilization; structure-based design

The elicitation of autologous neutralizing responses by immunization with HIV-1 envelope (Env) trimers conformationally stabilized in a prefusion closed state has generated considerable interest in the HIV-1 vaccine field. However, soluble prefusion closed Env trimers have been produced from only a...