Physiologically Based Pharmacokinetic Modeling Framework to Predict Neonatal Pharmacokinetics of Transplacentally Acquired Emtricitabine, Dolutegravir, and Raltegravir

• Published in: Clinical pharmacokinetics Vol. 60; no. 6; pp. 795 - 809
• Main Authors: Liu, Xiaomei I., Momper, Jeremiah D., Rakhmanina, Natella Y., Green, Dionna J., Burckart, Gilbert J., Cressey, Tim R., Mirochnick, Mark, Best, Brookie M., van den Anker, John N., Dallmann, André
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2021; Springer Nature B.V
• Subjects: Antiretroviral drugs; Drug dosages; Enzymes; Fetuses; HIV; Human immunodeficiency virus; Internal Medicine; Medicine; Medicine & Public Health; Metabolism; Metabolites; Open source software; Original Research Article; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Physiology; Plasma; Pregnancy

Background and Objective Little is understood about neonatal pharmacokinetics immediately after delivery and during the first days of life following intrauterine exposure to maternal medications. Our objective was to develop and evaluate a novel, physiologically based pharmacokinetic modeling workfl...