Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)

• Published in: Archives of toxicology Vol. 97; no. 3; pp. 685 - 696
• Main Authors: Louisse, Jochem, Dellafiora, Luca, van den Heuvel, Jeroen J. M. W., Rijkers, Deborah, Leenders, Liz, Dorne, Jean-Lou C. M., Punt, Ans, Russel, Frans G. M., Koenderink, Jan B.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2023; Springer Nature B.V
• Subjects: Accumulation; Alkanesulfonic Acids - metabolism; Animals; Biomedical and Life Sciences; Biomedicine; Carrier Proteins - metabolism; Congeners; Environmental Health; Fluorocarbons - metabolism; Humans; Kidney - metabolism; Kidney Tubules, Proximal - metabolism; Kidneys; Molecular docking; Molecular dynamics; Occupational Medicine/Industrial Medicine; Organic Anion Transporters - metabolism; Perfluoroalkyl & polyfluoroalkyl substances; Perfluorochemicals; Pharmacology/Toxicology; Protein transport; Proximal tubules; Reabsorption; Substrates; Toxicokinetics and Metabolism; Urine; PFASs; URAT1; Transporter; Renal reabsorption; In vitro; OAT4

Poly- and perfluoroalkyl substances (PFASs) are omnipresent in the environment and have been shown to accumulate in humans. Most PFASs are not biotransformed in animals and humans, so that elimination is largely dependent on non-metabolic clearance via bile and urine. Accumulation of certain PFASs i...