Pseudomonas aeruginosa T6SS-mediated molybdate transport contributes to bacterial competition during anaerobiosis

• Published in: Cell reports (Cambridge) Vol. 35; no. 2; p. 108957
• Main Authors: Wang, Tietao, Du, Xiao, Ji, Linxuan, Han, Yuying, Dang, Jing, Wen, Jing, Wang, Yarong, Pu, Qinqin, Wu, Min, Liang, Haihua
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.04.2021; Elsevier
• Subjects: anaerobic condition; Anaerobiosis - genetics; Animals; Anr regulator; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Carrier Proteins - genetics; Carrier Proteins - metabolism; Female; Gene Expression Regulation, Bacterial; Ion Transport; Metalloendopeptidases - genetics; Metalloendopeptidases - metabolism; Mice; Mice, Inbred C57BL; Microbial Interactions - genetics; Microbial Viability; molybdate acquisition; Molybdenum - metabolism; Pseudomonas aeruginosa; Pseudomonas aeruginosa - genetics; Pseudomonas aeruginosa - metabolism; Pseudomonas aeruginosa - pathogenicity; Pseudomonas Infections - microbiology; Pseudomonas Infections - mortality; Pseudomonas Infections - pathology; Survival Analysis; T6SS; Trans-Activators - genetics; Trans-Activators - metabolism; Type VI Secretion Systems - genetics; Type VI Secretion Systems - metabolism; Virulence; Virulence Factors - genetics; Virulence Factors - metabolism; Pseudomonas aeruginosa; molybdate acquisition; anaerobic condition; T6SS; Anr regulator

Type VI secretion system (T6SS) is widely distributed in Gram-negative bacteria and functions as a versatile protein export machinery that translocates effectors into eukaryotic or prokaryotic target cells. Growing evidence indicates that T6SS can deliver several effectors to promote bacterial survi...