Glymphatic MRI in idiopathic normal pressure hydrocephalus

• Published in: Brain (London, England : 1878) Vol. 140; no. 10; pp. 2691 - 2705
• Main Authors: Ringstad, Geir, Vatnehol, Svein Are Sirirud, Eide, Per Kristian
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.10.2017
• Subjects: Adult; Aged; Aged, 80 and over; Contrast Media - pharmacokinetics; Female; Humans; Hydrocephalus, Normal Pressure - cerebrospinal fluid; Hydrocephalus, Normal Pressure - diagnostic imaging; Image Processing, Computer-Assisted; Magnetic Resonance Imaging - methods; Male; Middle Aged; Organometallic Compounds - pharmacokinetics; Original; Prospective Studies; Subarachnoid Space - diagnostic imaging; Subarachnoid Space - pathology; Time Factors; MRI; idiopathic normal pressure hydrocephalus; gadobutrol; glymphatic function; cerebrospinal fluid

The glymphatic system has in previous studies been shown as fundamental to clearance of waste metabolites from the brain interstitial space, and is proposed to be instrumental in normal ageing and brain pathology such as Alzheimer's disease and brain trauma. Assessment of glymphatic function us...