TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877

• Published in: Scientific reports Vol. 9; no. 1; pp. 13470 - 10
• Main Authors: Antonia, Ricardo J., Castillo, Johnny, Herring, Laura E., Serafin, D. Stephen, Liu, Pengda, Graves, Lee M., Baldwin, Albert S., Hagan, Robert S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.09.2019; Nature Publishing Group
• Subjects: 13/106; 13/89; 631/250/262; 631/45/275; 631/80/86; 82/58; 96/1; 96/106; 96/109; 96/95; Amino Acid Sequence; Autophagy; Cell Line; Enzyme Activation; Humanities and Social Sciences; Humans; Immune system; Immunity, Innate; Innate immunity; Kinases; Mass Spectrometry; Mass spectroscopy; Mechanistic Target of Rapamycin Complex 1 - chemistry; Mechanistic Target of Rapamycin Complex 1 - metabolism; Models, Molecular; multidisciplinary; Phagocytosis; Phosphorylation; Protein Binding; Protein-Serine-Threonine Kinases - chemistry; Protein-Serine-Threonine Kinases - metabolism; Rapamycin; Regulatory-Associated Protein of mTOR - chemistry; Regulatory-Associated Protein of mTOR - metabolism; Science; Science (multidisciplinary); Serine - metabolism; Signal Transduction; Structure-Activity Relationship; TOR protein

While best known for its role in the innate immune system, the TANK-binding kinase 1 (TBK1) is now known to play a role in modulating cellular growth and autophagy. One of the major ways that TBK1 accomplishes this task is by modulating the mechanistic Target of Rapamycin (mTOR), a master regulator...