High-throughput elucidation of thrombus formation reveals sources of platelet function variability

• Published in: Haematologica (Roma) Vol. 104; no. 6; pp. 1256 - 1267
• Main Authors: van Geffen, Johanna P., Brouns, Sanne L.N., Batista, Joana, McKinney, Harriet, Kempster, Carly, Nagy, Magdolna, Sivapalaratnam, Suthesh, Baaten, Constance C.F.M.J., Bourry, Nikki, Frontini, Mattia, Jurk, Kerstin, Krause, Manuela, Pillitteri, Daniele, Swieringa, Frauke, Verdoold, Remco, Cavill, Rachel, Kuijpers, Marijke J. E., Ouwehand, Willem H., Downes, Kate, Heemskerk, Johan W.M.
• Format: Journal Article
• Language: English
• Published: Italy Ferrata Storti Foundation 01.06.2019
• Subjects: Biomarkers; Blood Platelets - metabolism; Flow Cytometry; High-Throughput Screening Assays; Humans; Immunophenotyping; Platelet Activation; Platelet Aggregation; Platelet Count; Platelet Function Tests; Platelet Membrane Glycoproteins - metabolism; Thrombosis - diagnosis; Thrombosis - etiology; Thrombosis - metabolism

In combination with microspotting, whole-blood microfluidics can provide high-throughput information on multiple platelet functions in thrombus formation. Based on assessment of the inter- and intra-subject variability in parameters of microspot-based thrombus formation, we aimed to determine the pl...