Renal fibrosis detected by diffusion-weighted magnetic resonance imaging remains unchanged despite treatment in subjects with renovascular disease

• Published in: Scientific reports Vol. 10; no. 1; p. 16300
• Main Authors: Ferguson, Christopher M., Eirin, Alfonso, Abumoawad, Abdelrhman, Saad, Ahmed, Jiang, Kai, Hedayat, Ahmad F., Misra, Sanjay, Glockner, James, Textor, Stephen C., Lerman, Lilach O.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2020; Nature Publishing Group
• Subjects: 692/4019; 692/4022; Aged; Angioplasty; Biopsy; Blood pressure; Creatinine; Diffusion coefficient; Diffusion Magnetic Resonance Imaging; Epidermal growth factor receptors; Female; Fibrosis; Humanities and Social Sciences; Humans; Hypoxia; Inflammation; Kidney - diagnostic imaging; Kidney - pathology; Kidneys; Magnetic resonance imaging; Male; multidisciplinary; Oxygenation; Patients; Renal Artery Obstruction - diagnostic imaging; Renal Artery Obstruction - pathology; Renal Artery Obstruction - therapy; Renal function; Science; Science (multidisciplinary); Treatment Outcome; Tumor necrosis factor-α

Tissue fibrosis is an important index of renal disease progression. Diffusion-weighted magnetic resonance imaging’s (DWI-MRI) apparent diffusion coefficient (ADC) reveals water diffusion is unobstructed by microstructural alterations like fibrosis. We hypothesized that ADC may indicate renal injury...