Diagnosis of NTM active infection in lymphadenopathy patients with anti-interferon-gamma auto-antibody using inhibitory ELISA vs. indirect ELISA

• Published in: Scientific reports Vol. 10; no. 1; p. 8968
• Main Authors: Nithichanon, Arnone, Chetchotisakd, Ploenchan, Matsumura, Takayuki, Takahashi, Yoshimasa, Ato, Manabu, Sakagami, Takuro, Lertmemongkolchai, Ganjana
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.06.2020; Nature Publishing Group
• Subjects: 631/250; 631/326; 692/308; 692/699; 692/700; Adult; Antibodies; Autoantibodies; Autoantibodies - blood; Biomarkers - blood; Diagnosis; Enzyme-linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - methods; Female; Humanities and Social Sciences; Humans; Infections; Interferon-gamma - immunology; Lymphadenopathy; Lymphadenopathy - complications; Male; multidisciplinary; Mycobacterium Infections, Nontuberculous - complications; Mycobacterium Infections, Nontuberculous - diagnosis; Opportunistic Infections - complications; Opportunistic Infections - diagnosis; Patients; Predictive Value of Tests; Retrospective Studies; Science; Science (multidisciplinary); Sensitivity and Specificity; Tuberculosis; γ-Interferon

The anti-interferon-gamma (IFN-gamma) autoantibody is a known cause of opportunistic non-tuberculous mycobacterial (NTM) infection in adults. Diagnosis of those patients is difficult due to the low sensitivity of bacterial culture, and because detection of the neutralizing autoantibody needs special...