PKCγ promotes axonal remodeling in the cortico-spinal tract via GSK3β/β-catenin signaling after traumatic brain injury

• Published in: Scientific reports Vol. 9; no. 1; pp. 17078 - 16
• Main Authors: Zhang, Bo, Li, Zaiwang, Zhang, Rui, Hu, Yaling, Jiang, Yingdi, Cao, Tingting, Wang, Jingjing, Gong, Lingli, Ji, Li, Mu, Huijun, Yang, Xusheng, Dai, Youai, Jiang, Cheng, Yin, Ying, Zou, Jian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.11.2019; Nature Publishing Group
• Subjects: 13/1; 13/100; 13/109; 13/44; 13/51; 14/19; 14/34; 14/63; 631/378/1687; 631/378/340; 64/60; Animals; Axon guidance; Axonogenesis; Axons - drug effects; Axons - metabolism; beta Catenin - genetics; beta Catenin - metabolism; Brain Injuries, Traumatic - physiopathology; Fibers; Glycogen Synthase Kinase 3 beta - genetics; Glycogen Synthase Kinase 3 beta - metabolism; Humanities and Social Sciences; Male; Mice; Mice, Inbred BALB C; multidisciplinary; Nerve Regeneration; Neurons - cytology; Neurons - drug effects; Neurons - metabolism; Phosphorylation; Protein kinase C; Protein Kinase C - pharmacology; Pyramidal tracts; Pyramidal Tracts - cytology; Pyramidal Tracts - drug effects; Pyramidal Tracts - metabolism; Recovery of Function; Science; Science (multidisciplinary); Sensorimotor system; Signal Transduction; Spinal cord; Spinal cord injuries; Therapeutic applications; Traumatic brain injury; β-Catenin

Traumatic brain injury (TBI) is a common cause of death and disability. Enhancing the midline-crossing of the contralateral corticospinal tract (CST) to the denervated side of spinal cord facilitates functional recovery after TBI. Activation of the gamma isoform of PKC (PKCγ) in contralateral CST im...