Participation of Monocarboxylate Transporter 8, But Not P-Glycoprotein, in Carrier-Mediated Cerebral Elimination of Phenytoin across the Blood-Brain Barrier - Jomura, Ryuta; Akanuma, Shin-ichi; Bauer, Björn; Yoshida, Yukiko; Kubo, Yoshiyuki; Hosoya, Ken-ichi (Pharmaceutical research, 2021)
Keywords: Animals; Anticonvulsants - administration & dosage; Anticonvulsants - pharmacokinetics; ATP Binding Cassette Transporter, Subfamily B - genetics; ATP Binding Cassette Transporter, Subfamily B - metabolism; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Blood-brain barrier; Blood-Brain Barrier - metabolism; Brain slice preparation; Capillaries; Female; Gene expression; Glycoproteins; Half-Life; Male; Medical Law; Mice; Mice, Transgenic; Models, Animal; Monocarboxylic Acid Transporters - metabolism; Oocytes; P-Glycoprotein; Perfusion; Pharmacology/Toxicology; Pharmacy; Phenytoin; Phenytoin - administration & dosage; Phenytoin - pharmacokinetics; Rats; Research Paper; Symporters - metabolism; Xenopus; blood-brain barrier; P-glycoprotein; monocarboxylate transporter; phenytoin; MCT8