Multi modular toxicity assessment of nephrotoxicity in podophyllotoxin exposure rats on account of toxicological evidence chain (TEC) concept

• Published in: Ecotoxicology and environmental safety Vol. 231; p. 113157
• Main Authors: Kong, Jiao, He, Tao, Liu, Chuanxin, Huang, Jianmei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.02.2022; Elsevier
• Subjects: Animals; Grades of toxicological evidence assessment; Kidney; Mechanism of nephrotoxicity; Metabolome; Metabolomics; Podophyllotoxin; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Toxicological evidence chain; Toxicological evidence chain; Podophyllotoxin; Mechanism of nephrotoxicity; Grades of toxicological evidence assessment

Early diagnosis of kidney injuries caused by herbs is necessary to enable effective treatments, prevent kidney failure and promote the internationalization and modernization of herbal medicine. Whereas the toxic assessment evidence has not integrated yet, and the evaluation method has not been unani...