MTDH/AEG-1 contributes to central features of the neoplastic phenotype in bladder cancer

• Published in: Urologic oncology Vol. 32; no. 5; pp. 670 - 677
• Main Authors: Nikpour, Mahnaz, Emadi-Baygi, Modjtaba, Fischer, Ute, Niegisch, Günter, Schulz, Wolfgang A., Nikpour, Parvaneh
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2014
• Subjects: Aged; Aged, 80 and over; Anchorage-independent growth; Apoptosis; Bladder cancer; Caspase 3 - metabolism; Caspase 7 - metabolism; Cell Adhesion Molecules - metabolism; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Survival; Down-Regulation; Female; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; MTDH/AEG-1; Phenotype; RNA Interference; RNA, Small Interfering - metabolism; Urinary Bladder - metabolism; Urinary Bladder Neoplasms - metabolism; Urology; Wound Healing; Cell survival; Anchorage-independent growth; Bladder cancer; MTDH/AEG-1

Carcinoma of the bladder is the fifth most common cancer whose incidence continues to rise. MTDH/AEG-1 is associated with the initiation and progression of many cancers including breast, hepatocellular, ovarian, and colorectal carcinomas. However, the expression and functional importance of MTDH/AEG...