Fatty liver is associated with blood pathways of inflammatory response, immune system activation and prothrombotic state in Young Finns Study

• Published in: Scientific reports Vol. 8; no. 1; pp. 10358 - 9
• Main Authors: Taipale, Tuukka, Seppälä, Ilkka, Raitoharju, Emma, Mononen, Nina, Lyytikäinen, Leo-Pekka, Illig, Thomas, Waldenberger, Melanie, Juonala, Markus, Hutri-Kähönen, Nina, Oksala, Niku, Kähönen, Mika, Raitakari, Olli, Lehtimäki, Terho
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.07.2018; Nature Publishing Group
• Subjects: 38/39; 692/1807/4024; 692/4019/592/1339; 692/698/2741/288/2032; 692/699/1503/1607/2750; 692/699/249/2510/2100; Alcohol use; Cardiovascular diseases; CD40 antigen; CD40L protein; Extracellular matrix; Fatty liver; Gene expression; Gene set enrichment analysis; Genomes; Hepatocytes; Humanities and Social Sciences; Immune response; Immune system; Inflammation; Leukocyte migration; Liver; Liver diseases; multidisciplinary; Netrin-1; Peripheral blood; Risk factors; Science; Science (multidisciplinary); Signal transduction

Fatty liver (FL) disease is the most common type of chronic liver disease. We hypothesized that liver’s response to the process where large droplets of triglyceride fat accumulate in liver cells is reflected also in gene pathway expression in blood. Peripheral blood genome wide gene expression analy...