Royal jelly mediates fibrotic signaling, collagen cross-linking and cell proliferation in cardiac fibroblasts

• Published in: Biomedicine & pharmacotherapy Vol. 164; p. 114922
• Main Authors: Al-U’datt, Doa’a G.F., Alu’datt, Muhammad H., Tranchant, Carole C., Al-Dwairi, Ahmed, Al-shboul, Othman, Almajwal, Ali, Elsalem, Lina, Jaradat, Saied, Alzoubi, Karem H., Faleh, Belal G., Ahmed, Yaman B., Alqbelat, Jenan
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.08.2023; Elsevier
• Subjects: Animals; bcl-2-Associated X Protein - metabolism; Bees; Bioactivity; Cardiac fibrosis; Cell Proliferation; Collagen - metabolism; Fatty Acids - metabolism; Fibroblasts; Fibrosis; Fibrotic markers; Rats; Royal jelly; Sonication; Fibrotic markers; Sonication; NS; CTGF; MRJP; α-SMA; BCL-2; Cardiac fibrosis; S; CCND1; Fibroblasts; RT-qPCR; TG2; TG1; Royal jelly; FN1; CX43; ECM; COL1A1; CVD; COL3A1; CCNE2; MMP-2; ROS; RJ; BAX; TGF-β1; Bioactivity; MMP-9

Royal jelly (RJ) is a multifunctional bee product with a unique composition and wide-ranging biological properties, including antioxidant, anti-inflammatory and antiproliferative activities. Still, little is known about the possible myocardial protective properties of RJ. Considering that sonication...