TCA cycle rewiring fosters metabolic adaptation to oxygen restriction in skeletal muscle from rodents and humans

• Published in: Scientific reports Vol. 7; no. 1; pp. 9723 - 16
• Main Authors: Capitanio, Daniele, Fania, Chiara, Torretta, Enrica, Viganò, Agnese, Moriggi, Manuela, Bravatà, Valentina, Caretti, Anna, Levett, Denny Z. H., Grocott, Michael P. W., Samaja, Michele, Cerretelli, Paolo, Gelfi, Cecilia
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.08.2017; Nature Publishing Group
• Subjects: 38; 38/77; 631/45/475/2290; 692/4017; 82; 82/1; 82/29; 82/58; Adaptation, Physiological; Animals; Autophagy; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; Citric Acid Cycle; Energy demand; Energy Metabolism; Enzymatic activity; Gene Expression; Glutamine; Hexosamines - metabolism; High-altitude environments; Homeostasis; Human subjects; Humanities and Social Sciences; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Metabolic Networks and Pathways; Metabolism; Models, Biological; multidisciplinary; Muscle, Skeletal - metabolism; Musculoskeletal system; Oxygen - metabolism; Proteome; Proteomics; Proteomics - methods; Rodentia; Rodents; Science; Science (multidisciplinary); Signal Transduction; Skeletal muscle; Time Factors; Tricarboxylic acid cycle

In mammals, hypoxic stress management is under the control of the Hypoxia Inducible Factors, whose activity depends on the stabilization of their labile α subunit. In particular, the skeletal muscle appears to be able to react to changes in substrates and O 2 delivery by tuning its metabolism. The p...