Long noncoding RNAs of single hematopoietic stem and progenitor cells in healthy and dysplastic human bone marrow

• Published in: Haematologica (Roma) Vol. 104; no. 5; pp. 894 - 906
• Main Authors: Wu, Zhijie, Gao, Shouguo, Zhao, Xin, Chen, Jinguo, Keyvanfar, Keyvan, Feng, Xingmin, Kajigaya, Sachiko, Young, Neal S.
• Format: Journal Article
• Language: English
• Published: Italy Ferrata Storti Foundation 01.05.2019
• Subjects: Biomarkers, Tumor - genetics; Bone Marrow - metabolism; Bone Marrow - pathology; Cell Differentiation; Cells, Cultured; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hematopoiesis; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; High-Throughput Nucleotide Sequencing; Humans; Myelodysplastic Syndromes - genetics; Myelodysplastic Syndromes - pathology; RNA, Long Noncoding - genetics; Single-Cell Analysis - methods; Transcriptome

Long noncoding RNAs (lncRNAs) are regulators of cell differentiation and development. The lncRNA transcriptome in human hematopoietic stem and progenitor cells is not comprehensively defined. We investigated lncRNAs in 979 human bone marrow-derived CD34 cells by single cell RNA sequencing followed b...