Visceral fat inflammation and fat embolism are associated with lung’s lipidic hyaline membranes in subjects with COVID-19

• Published in: International Journal of Obesity Vol. 46; no. 5; pp. 1009 - 1017
• Main Authors: Colleluori, Georgia, Graciotti, Laura, Pesaresi, Mauro, Di Vincenzo, Angelica, Perugini, Jessica, Di Mercurio, Eleonora, Caucci, Sara, Bagnarelli, Patrizia, Zingaretti, Cristina M., Nisoli, Enzo, Menzo, Stefano, Tagliabracci, Adriano, Ladoux, Annie, Dani, Christian, Giordano, Antonio, Cinti, Saverio
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2022; Nature Publishing Group
• Subjects: 14; 14/28; 14/63; 38; 38/77; 692/699/2743/2037; 692/699/2743/393; 82/51; Adipocytes; Adipose tissue; Body size; Cell viability; Coronaviruses; COVID-19; COVID-19 - complications; COVID-19 Testing; Embolism; Embolism, Fat; Embolisms; Endothelial cells; Endothelial Cells - metabolism; Epidemiology; Health Promotion and Disease Prevention; Humans; Hyalin - metabolism; Inflammation; Inflammation - metabolism; Internal Medicine; Intra-Abdominal Fat - metabolism; Lipids; Lung; Lungs; Macrophages; Medicine; Medicine & Public Health; Membranes; Metabolic Diseases; Obesity; Obesity - metabolism; Pneumonia; Public Health; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Viral diseases

Background Preliminary data suggested that fat embolism could explain the importance of visceral obesity as a critical determinant of coronavirus disease-2019 (COVID-19). Methods We performed a comprehensive histomorphologic analysis of autoptic visceral adipose tissue (VAT), lungs and livers of 19...