Coupling between Inclusions and Membranes at the Nanoscale
The activity of cell membrane inclusions (such as ion channels) is influenced by the host lipid membrane, to which they are elastically coupled. This coupling concerns the hydrophobic thickness of the bilayer (imposed by the length of the channel, as per the hydrophobic matching principle) but also...
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| Published in | Physical review letters Vol. 120; no. 12; p. 128104 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
23.03.2018
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| Online Access | Get more information |
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| Abstract | The activity of cell membrane inclusions (such as ion channels) is influenced by the host lipid membrane, to which they are elastically coupled. This coupling concerns the hydrophobic thickness of the bilayer (imposed by the length of the channel, as per the hydrophobic matching principle) but also its slope at the boundary of the inclusion. However, this parameter has never been measured so far. We combine small-angle x-ray scattering data and a complete elastic model to measure the slope for the model gramicidin channel and show that it is surprisingly steep in two membrane systems with very different elastic properties. This conclusion is confirmed and generalized by the comparison with recent results in the simulation literature and with conductivity measurements. |
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| AbstractList | The activity of cell membrane inclusions (such as ion channels) is influenced by the host lipid membrane, to which they are elastically coupled. This coupling concerns the hydrophobic thickness of the bilayer (imposed by the length of the channel, as per the hydrophobic matching principle) but also its slope at the boundary of the inclusion. However, this parameter has never been measured so far. We combine small-angle x-ray scattering data and a complete elastic model to measure the slope for the model gramicidin channel and show that it is surprisingly steep in two membrane systems with very different elastic properties. This conclusion is confirmed and generalized by the comparison with recent results in the simulation literature and with conductivity measurements. |
| Author | Galatola, Paolo Constantin, Doru Fournier, Jean-Baptiste Bories, Florent |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29694104$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1103_PhysRevE_99_022401 crossref_primary_10_1103_PhysRevResearch_3_L042013 crossref_primary_10_1016_j_bpj_2022_12_009 crossref_primary_10_3389_fmolb_2021_811711 crossref_primary_10_1016_j_cocis_2019_01_006 crossref_primary_10_1039_C9SM02079A crossref_primary_10_1134_S1990747822030060 crossref_primary_10_3390_biom8040104 |
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| Snippet | The activity of cell membrane inclusions (such as ion channels) is influenced by the host lipid membrane, to which they are elastically coupled. This coupling... |
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| Title | Coupling between Inclusions and Membranes at the Nanoscale |
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