Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress

• Published in: Nucleic acids research Vol. 46; no. 18; pp. 9601 - 9616
• Main Authors: Liu, Xiaofeng, Cai, Shiying, Zhang, Chunfeng, Liu, Zhenzhen, Luo, Jianyuan, Xing, Baocai, Du, Xiaojuan
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 12.10.2018
• Subjects: Acetylation; Apoptosis Regulatory Proteins - genetics; Autophagy - genetics; Cell Nucleolus - metabolism; Humans; Intracellular Signaling Peptides and Proteins - genetics; Metabolism - genetics; Molecular Biology; N-Terminal Acetyltransferase E - genetics; N-Terminal Acetyltransferase E - metabolism; N-Terminal Acetyltransferases; Repressor Proteins - genetics; RNA, Ribosomal - biosynthesis; RNA, Ribosomal - genetics; RNA, Ribosomal - metabolism; Sirtuin 1 - genetics; Stress, Physiological - genetics; Transcription Factors - genetics

Abstract Anabolism and catabolism are tightly regulated according to the cellular energy supply. Upon energy stress, ribosomal RNA (rRNA) biogenesis is inhibited, and autophagy is induced. However, the mechanism linking rRNA biogenesis and autophagy is unclear. Here, we demonstrate that the nucleola...