Achieving clinical success with BET inhibitors as anti-cancer agents

• Published in: British journal of cancer Vol. 124; no. 9; pp. 1478 - 1490
• Main Authors: Shorstova, Tatiana, Foulkes, William D., Witcher, Michael
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.04.2021; Nature Publishing Group
• Subjects: 631/67/1059/602; 692/53/2423; Antineoplastic Agents - therapeutic use; Antitumor agents; Biomarkers; Biomedical and Life Sciences; Biomedicine; Cancer Research; Chromatin; Drug Resistance; Epidemiology; Humans; Molecular Medicine; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; Oncology; Prognosis; Proteins - antagonists & inhibitors; Review; Review Article; Transcription; Transcription Factors - antagonists & inhibitors; Tumors

The transcriptional upregulation of oncogenes is a driving force behind the progression of many tumours. However, until a decade ago, the concept of ‘switching off’ these oncogenic pathways represented a formidable challenge. Research has revealed that members of the bromo- and extra-terminal domain...