Tumour treating fields therapy for glioblastoma: current advances and future directions

• Published in: British journal of cancer Vol. 124; no. 4; pp. 697 - 709
• Main Authors: Rominiyi, Ola, Vanderlinden, Aurelie, Clenton, Susan Jane, Bridgewater, Caroline, Al-Tamimi, Yahia, Collis, Spencer James
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.02.2021; Nature Publishing Group
• Subjects: 631/67/1922; 639/766; 692/4028/67/1059/485; 692/4028/67/1059/602; 692/4028/67/1059/99; Animals; Biomedical and Life Sciences; Biomedicine; Brain cancer; Brain Neoplasms - pathology; Brain Neoplasms - therapy; Brain tumors; Cancer; Cancer Research; Cell permeability; Cell proliferation; Chemoradiotherapy; Chemotherapy; Clinical trials; Clinical Trials, Phase III as Topic; DNA repair; Drug Resistance; Electric fields; Electric Stimulation Therapy - methods; Epidemiology; Glioblastoma; Glioblastoma - pathology; Glioblastoma - therapy; Humans; Mesothelioma; Molecular Medicine; Oncology; Radiation therapy; Randomized Controlled Trials as Topic; Review; Review Article; Surgery

Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and continues to portend poor survival, despite multimodal treatment using surgery and chemoradiotherapy. The addition of tumour-treating fields (TTFields)—an approach in which alternating electrical fields exert biophys...