Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

• Published in: Cell reports (Cambridge) Vol. 31; no. 1; p. 107469
• Main Authors: Cohrs, Christian M., Panzer, Julia K., Drotar, Denise M., Enos, Stephen J., Kipke, Nicole, Chen, Chunguang, Bozsak, Robert, Schöniger, Eyke, Ehehalt, Florian, Distler, Marius, Brennand, Ana, Bornstein, Stefan R., Weitz, Jürgen, Solimena, Michele, Speier, Stephan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.04.2020; Elsevier
• Subjects: Aged; beta cell function; beta cell mass; Blood Glucose - metabolism; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Female; Glucose - metabolism; human pancreas; Humans; Insulin - metabolism; Insulin Resistance - physiology; insulin secretion; Insulin Secretion - physiology; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - pathology; Islets of Langerhans - metabolism; Male; Middle Aged; Pancreas - metabolism; Type 2 diabetes; Type 2 diabetes; insulin secretion; beta cell function; human pancreas; beta cell mass

Type 2 diabetes is characterized by peripheral insulin resistance and insufficient insulin release from pancreatic islet β cells. However, the role and sequence of β cell dysfunction and mass loss for reduced insulin levels in type 2 diabetes pathogenesis are unclear. Here, we exploit freshly explan...