Clinical and Preclinical Single-Dose Pharmacokinetics of VIR-2218, an RNAi Therapeutic Targeting HBV Infection - Gupta, Sneha V.; Fanget, Marie C.; MacLauchlin, Christopher; Clausen, Valerie A.; Li, Jing; Cloutier, Daniel; Shen, Ling; Robbie, Gabriel J.; Mogalian, Erik (Drugs in R&D, 2021)
Keywords: Animals; Area Under Curve; Biotechnology; Enzymes; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infections; Internal Medicine; Ligands; Liver cancer; Liver cirrhosis; Medicine; Medicine & Public Health; Metabolism; Metabolites; NCT; NCT00071487; NCT00410384; NCT00424476; NCT00657007; NCT01345253; NCT01516450; NCT01583530; NCT02880852; NCT03672188; Original; Original Research Article; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Plasma; Protein expression; Proteins; Rats; RNA Interference; RNAi Therapeutics; Urine