ApaI Polymorphism in the Vitamin D Receptor Gene Decreases the Risk of Perianal Fistulas in Crohn’s Disease

• Published in: Nutrients Vol. 16; no. 20; p. 3485
• Main Authors: Gisbert-Ferrándiz, Laura, Llau, Jorge, Ortiz-Masia, Dolores, Cosín-Roger, Jesús, Macias-Ceja, Dulce Carolina, Hinojosa, Joaquín, Calatayud, Sara, Barrachina, Maria Dolores
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.10.2024; MDPI
• Subjects: Adult; Alfacalcidol; Anorectal fistula; Calcifediol; Complications and side effects; Crohn Disease - genetics; Crohn's disease; Ethnicity; Female; Fibroblasts; Fibroblasts - metabolism; Fistula; Genetic aspects; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; Haplotypes; Health aspects; Hospitals; Humans; Inflammatory bowel disease; Linkage Disequilibrium; Male; Middle Aged; Physiological aspects; Polymorphism; Polymorphism, Single Nucleotide; Receptors, Calcitriol - genetics; Rectal Fistula - genetics; Risk Factors; Single nucleotide polymorphisms; Surgery; Vitamin D; White people; Young Adult; Spain; United States > US; Germany; BsmI; TaqI; fibroblasts; FokI; penetrating behavior; ApaI; perianal fistula; vitamin D receptor; single-nucleotide polymorphisms; Crohn’s disease
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu16203485

Background: Vitamin D, through the activation of its receptor (VDR), plays an immunomodulatory role in the gastrointestinal tract. Single-nucleotide polymorphisms (SNPs) in the VDR gene have been associated with Crohn’s disease (CD) risk, and patients carrying the TaqI polymorphism in this gene run...