Inflammatory Bowel Disease Types Differ in Markers of Inflammation, Gut Barrier and in Specific Anti-Bacterial Response

• Published in: Cells (Basel, Switzerland) Vol. 8; no. 7; p. 719
• Main Authors: Coufal, Stepan, Galanova, Natalie, Bajer, Lukas, Gajdarova, Zuzana, Schierova, Dagmar, Jiraskova Zakostelska, Zuzana, Kostovcikova, Klara, Jackova, Zuzana, Stehlikova, Zuzana, Drastich, Pavel, Tlaskalova-Hogenova, Helena, Kverka, Miloslav
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.07.2019; MDPI
• Subjects: Adult; Antibodies; Antigens; Bacteria; Biomarkers; Biomarkers - blood; Cadmium; CD14 antigen; Chemokines; Cholangitis; Cholangitis, Sclerosing - complications; Colitis, Ulcerative - complications; Colitis, Ulcerative - diagnosis; Colitis, Ulcerative - metabolism; Commensals; Crohn Disease - complications; Crohn Disease - diagnosis; Crohn Disease - metabolism; Crohn's disease; Cytokines; Disease; Dysbacteriosis; Dysbiosis - complications; E coli; Feces; Female; Flow cytometry; gut barrier; Humans; Immune system; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Intestine; Lymphocytes T; Male; Mannan; Mannose-binding lectin; Matrix metalloproteinase; Metalloproteinase; Microbiota; Middle Aged; Osteoprotegerin; Pathogenesis; Patients; Protein arrays; Proteins; T cells; Tissue inhibitor of metalloproteinase 1; Transforming growth factor-b1; Tumor necrosis factor-α; Ulcerative colitis; Czech Republic; microbiota; antibodies; T cells; gut barrier; biomarkers; inflammatory bowel disease

Crohn’s disease (CD), ulcerative colitis (UC) and inflammatory bowel disease (IBD) associated with primary sclerosing cholangitis (PSC-IBD), share three major pathogenetic mechanisms of inflammatory bowel disease (IBD)-gut dysbiosis, gut barrier failure and immune system dysregulation. While clinica...