Individual and cumulative association of commonly used biomarkers on frailty: a cross-sectional analysis of the Mexican Health and Aging Study
Frailty has been recognized as a common condition in older adults, however, there is scarce information on the association between frailty and commonly used biomarkers. The aim of this study was to assess the individual and cumulative association of biomarkers with frailty status. This is a cross-se...
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Published in | Aging clinical and experimental research Vol. 31; no. 10; pp. 1429 - 1434 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
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01.10.2019
Springer Nature B.V |
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Abstract | Frailty has been recognized as a common condition in older adults, however, there is scarce information on the association between frailty and commonly used biomarkers. The aim of this study was to assess the individual and cumulative association of biomarkers with frailty status. This is a cross-sectional analysis of the 2012 wave of the Mexican Health and Aging Study. A sub-sample of 60-year or older adults with anthropometric measurements was analyzed. Frailty was defined with a 31-item frailty index and those considered frail had a score ≥ 0.21. Biomarkers were further categorized as normal/abnormal and tested both one by one and grouped (according to their usual cutoff values). Adjusted logistic models were performed. A total of 1128 older adults were analyzed and their mean age was 69.45 years and 51.24% of them were women. 26.7% (
n
= 301) were categorized as frail. Individual biomarkers associated with frailty after adjusting for confounding were: hemoglobin [odds ratio (OR) 1.67, 95% confidence interval (CI) 1.13–2.46,
p
= 0.009], glycated hemoglobin (OR 2.04, 95% CI 1.54–2.7,
p
< 0.001) and vitamin D (OR 1.53, 95% CI 1.13–2.07,
p
= 0.005). Those with ≥ 4 abnormal biomarkers had an independent association with frailty when compared to those without any abnormal biomarker (OR 2.64, 95% CI 1.3–5.25,
p
= 0.005). Aside from the individual associations of specific biomarkers, our findings show that an incremental association of abnormal biomarkers increases the probability of frailty, accounting for the multidimensional nature of frailty and the possible interplay between components of the system that potentiate to give rise to a negative condition such as frailty. |
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AbstractList | Frailty has been recognized as a common condition in older adults, however there is scarce information on the association between frailty and commonly used biomarkers. The aim of this study was to assess the individual and cumulative association of biomarkers with frailty status. This is a cross-sectional analysis of the 2012 wave of the Mexican Health and Aging Study. A sub-sample of 60-year or older adults with anthropometric measurements was analyzed. Frailty was defined with a 31-item frailty index and those considered frail had a score ≥0.21. Biomarkers were further categorized as normal/abnormal and tested both one by one and grouped (according to their usual cut-off values). Adjusted logistic models were performed. From a total of 1,128 older adults their mean age was of 69.45 years and 51.24% were women. 26.7% (n=301) were categorized as frail. Individual biomarkers associated with frailty after adjusting for confounding were: hemoglobin (odds ratio [OR] 1.67, 95% confidence interval [CI] 1.13–2.46, p=0.009), glycated hemoglobin (OR 2.04, 95% CI 1.54–2.7, p<0.001) and vitamin D (OR 1.53, 95% CI 1.13–2.07, p=0.005). Those with ≥4 abnormal biomarkers had an independent association with frailty when compared to those without any abnormal (OR 2.64, 95% CI 1.3–5.25, 0.005). Aside from the individual associations of specific biomarkers, our findings show that an incremental association of abnormal biomarkers increases the probability of frailty; accounting for the multidimensional nature of frailty and the possible interplay between components of the system that potentiate to give rise to a negative condition such as frailty. Frailty has been recognized as a common condition in older adults, however, there is scarce information on the association between frailty and commonly used biomarkers. The aim of this study was to assess the individual and cumulative association of biomarkers with frailty status. This is a cross-sectional analysis of the 2012 wave of the Mexican Health and Aging Study. A sub-sample of 60-year or older adults with anthropometric measurements was analyzed. Frailty was defined with a 31-item frailty index and those considered frail had a score ≥ 0.21. Biomarkers were further categorized as normal/abnormal and tested both one by one and grouped (according to their usual cutoff values). Adjusted logistic models were performed. A total of 1128 older adults were analyzed and their mean age was 69.45 years and 51.24% of them were women. 26.7% (n = 301) were categorized as frail. Individual biomarkers associated with frailty after adjusting for confounding were: hemoglobin [odds ratio (OR) 1.67, 95% confidence interval (CI) 1.13-2.46, p = 0.009], glycated hemoglobin (OR 2.04, 95% CI 1.54-2.7, p < 0.001) and vitamin D (OR 1.53, 95% CI 1.13-2.07, p = 0.005). Those with ≥ 4 abnormal biomarkers had an independent association with frailty when compared to those without any abnormal biomarker (OR 2.64, 95% CI 1.3-5.25, p = 0.005). Aside from the individual associations of specific biomarkers, our findings show that an incremental association of abnormal biomarkers increases the probability of frailty, accounting for the multidimensional nature of frailty and the possible interplay between components of the system that potentiate to give rise to a negative condition such as frailty. Frailty has been recognized as a common condition in older adults, however, there is scarce information on the association between frailty and commonly used biomarkers. The aim of this study was to assess the individual and cumulative association of biomarkers with frailty status. This is a cross-sectional analysis of the 2012 wave of the Mexican Health and Aging Study. A sub-sample of 60-year or older adults with anthropometric measurements was analyzed. Frailty was defined with a 31-item frailty index and those considered frail had a score ≥ 0.21. Biomarkers were further categorized as normal/abnormal and tested both one by one and grouped (according to their usual cutoff values). Adjusted logistic models were performed. A total of 1128 older adults were analyzed and their mean age was 69.45 years and 51.24% of them were women. 26.7% ( n = 301) were categorized as frail. Individual biomarkers associated with frailty after adjusting for confounding were: hemoglobin [odds ratio (OR) 1.67, 95% confidence interval (CI) 1.13–2.46, p = 0.009], glycated hemoglobin (OR 2.04, 95% CI 1.54–2.7, p < 0.001) and vitamin D (OR 1.53, 95% CI 1.13–2.07, p = 0.005). Those with ≥ 4 abnormal biomarkers had an independent association with frailty when compared to those without any abnormal biomarker (OR 2.64, 95% CI 1.3–5.25, p = 0.005). Aside from the individual associations of specific biomarkers, our findings show that an incremental association of abnormal biomarkers increases the probability of frailty, accounting for the multidimensional nature of frailty and the possible interplay between components of the system that potentiate to give rise to a negative condition such as frailty. Frailty has been recognized as a common condition in older adults, however, there is scarce information on the association between frailty and commonly used biomarkers. The aim of this study was to assess the individual and cumulative association of biomarkers with frailty status. This is a cross-sectional analysis of the 2012 wave of the Mexican Health and Aging Study. A sub-sample of 60-year or older adults with anthropometric measurements was analyzed. Frailty was defined with a 31-item frailty index and those considered frail had a score ≥ 0.21. Biomarkers were further categorized as normal/abnormal and tested both one by one and grouped (according to their usual cutoff values). Adjusted logistic models were performed. A total of 1128 older adults were analyzed and their mean age was 69.45 years and 51.24% of them were women. 26.7% (n = 301) were categorized as frail. Individual biomarkers associated with frailty after adjusting for confounding were: hemoglobin [odds ratio (OR) 1.67, 95% confidence interval (CI) 1.13–2.46, p = 0.009], glycated hemoglobin (OR 2.04, 95% CI 1.54–2.7, p < 0.001) and vitamin D (OR 1.53, 95% CI 1.13–2.07, p = 0.005). Those with ≥ 4 abnormal biomarkers had an independent association with frailty when compared to those without any abnormal biomarker (OR 2.64, 95% CI 1.3–5.25, p = 0.005). Aside from the individual associations of specific biomarkers, our findings show that an incremental association of abnormal biomarkers increases the probability of frailty, accounting for the multidimensional nature of frailty and the possible interplay between components of the system that potentiate to give rise to a negative condition such as frailty. |
Author | García-Peña, Carmen Pérez-Zepeda, Mario Ulises Carrillo-Vega, María Fernanda |
Author_xml | – sequence: 1 givenname: Mario Ulises orcidid: 0000-0003-4374-976X surname: Pérez-Zepeda fullname: Pérez-Zepeda, Mario Ulises organization: Instituto Nacional de Geriatría, Instituto de Envejecimiento, Facultad de Medicina, Pontificia Universidad Javeriana – sequence: 2 givenname: Carmen surname: García-Peña fullname: García-Peña, Carmen organization: Instituto Nacional de Geriatría – sequence: 3 givenname: María Fernanda orcidid: 0000-0001-9449-7561 surname: Carrillo-Vega fullname: Carrillo-Vega, María Fernanda email: marifercave@yahoo.com.mx organization: Instituto Nacional de Geriatría |
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Cites_doi | 10.1007/s40520-016-0678-3 10.1111/ggi.12805 10.1093/ageing/afv152 10.1093/gerona/gln026 10.1016/j.jamda.2013.03.022 10.1093/ageing/afv043 10.1111/j.1365-2265.2005.02355.x 10.1093/gerona/59.3.M242 10.1007/s10522-013-9446-3 10.1093/ageing/afh073 10.1111/acem.12569 10.3109/13685538.2015.1105796 10.1111/j.1532-5415.2010.03201.x 10.1007/BF03327404 10.1093/gerona/gln007 10.1111/jgs.14677 10.1210/jc.2010-2317 10.1093/ije/dyu263 10.1007/s40520-017-0852-2 10.1093/gerona/57.3.M162 10.1111/j.1532-5415.2006.00745.x 10.1089/thy.2013.0071 10.1016/j.jamda.2015.03.027 10.1186/1471-2318-9-47 10.1007/s11357-017-9993-7 10.1007/BF03344008 10.1093/gerona/glp076 10.1186/1471-2318-8-24 10.21149/spm.v57s1.7593 |
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Snippet | Frailty has been recognized as a common condition in older adults, however, there is scarce information on the association between frailty and commonly used... Frailty has been recognized as a common condition in older adults, however there is scarce information on the association between frailty and commonly used... |
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SubjectTerms | Aged Biomarkers Biomarkers - blood Cross-Sectional Studies Female Frail Elderly Frailty Frailty - diagnosis Geriatrics/Gerontology Hemoglobin Humans Logistic Models Male Medicine Medicine & Public Health Mexico Odds Ratio Older people Original Article |
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Title | Individual and cumulative association of commonly used biomarkers on frailty: a cross-sectional analysis of the Mexican Health and Aging Study |
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