Mitochondria-Targeted Small Peptide, SS31 Ameliorates Diabetes Induced Mitochondrial Dynamics in Male TallyHO/JngJ Mice

• Published in: Molecular neurobiology Vol. 58; no. 2; pp. 795 - 808
• Main Authors: Bhatti, Jasvinder Singh, Thamarai, Kavya, Kandimalla, Ramesh, Manczak, Maria, Yin, Xiangling, Kumar, Subodh, Vijayan, Murali, Reddy, P. Hemachandra
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2021; Springer Nature B.V
• Subjects: Adenosine Triphosphate - metabolism; Alzheimer's disease; Animals; Atrophy; Beta cells; Biomedical and Life Sciences; Biomedicine; Blood Glucose - metabolism; Body Weight; Cell Biology; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - genetics; Diabetes Mellitus, Experimental - immunology; Fasting - blood; Female; Gene expression; Glucose tolerance; Glucose Tolerance Test; Hydrogen peroxide; Hyperglycemia; Hyperglycemia - blood; Hyperglycemia - complications; Hyperglycemia - genetics; Hyperglycemia - pathology; Insulin Resistance; Lipid peroxidation; Lipid Peroxidation - drug effects; Male; Mice; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondrial Dynamics - drug effects; Neurobiology; Neurodegenerative diseases; Neurology; Neurosciences; Oligopeptides - pharmacology; Oligopeptides - therapeutic use; Oxidative stress; Pancreas; Peptides; Public health; RNA, Messenger - genetics; RNA, Messenger - metabolism; Type 2 diabetes; Oxidative stress; Mitochondrial dysfunction; TallyHO/JngJ mice; Alzheimer’s disease

The escalating burden of type 2 diabetes (T2D) and its related complications has become a major public health challenge worldwide. Substantial evidence indicates that T2D is one of the culprits for the high prevalence of Alzheimer’s disease (AD) in diabetic subjects. This study aimed to investigate...