Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development

Childhood psychiatric symptoms are often diffuse but can coalesce into discrete mental illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic risk for childhood symptoms and to uncover related neurodevelopmental mechanisms with transcriptomic and neuroimaging data....

Full description

Saved in:
Bibliographic Details
Published inNature neuroscience Vol. 26; no. 6; pp. 959 - 969
Main Authors Hughes, Dylan E., Kunitoki, Keiko, Elyounssi, Safia, Luo, Mannan, Bazer, Oren M., Hopkinson, Casey E., Dowling, Kevin F., Doyle, Alysa E., Dunn, Erin C., Eryilmaz, Hamdi, Gilman, Jodi M., Holt, Daphne J., Valera, Eve M., Smoller, Jordan W., Cecil, Charlotte A. M., Tiemeier, Henning, Lee, Phil H., Roffman, Joshua L.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.06.2023
Nature Publishing Group
Subjects
38/43
59/57
631/208/205/2138
631/208/366
631/378/1689/2608
631/378/2632/1368
Adolescent
Adolescents
Adult
Animal Genetics and Genomics
Attention Deficit Disorder with Hyperactivity - genetics
Attention deficit hyperactivity disorder
Autism
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain - pathology
Cerebellum
Cerebellum - diagnostic imaging
Child
Child development
Children
Cognition
Cognitive ability
Fetuses
Genes
Genomics
Gilles de la Tourette syndrome
Gray Matter
Humans
Illnesses
Medical imaging
Mental disorders
Neurobiology
Neurodevelopmental disorders
Neuroimaging
Neurosciences
Pattern formation
Pediatrics
Psychopathology
Risk
Risk sharing
Signs and symptoms
Substantia grisea
Transcriptomics
Online AccessGet full text

Cover

Abstract Childhood psychiatric symptoms are often diffuse but can coalesce into discrete mental illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic risk for childhood symptoms and to uncover related neurodevelopmental mechanisms with transcriptomic and neuroimaging data. In independent samples (Adolescent Brain Cognitive Development, Generation R) a narrow cross-disorder neurodevelopmental PGS, reflecting risk for attention deficit hyperactivity disorder, autism, depression and Tourette syndrome, predicted psychiatric symptoms through early adolescence with greater sensitivity than broad cross-disorder PGSs reflecting shared risk across eight psychiatric disorders, the disorder-specific PGS individually or two other narrow cross-disorder (Compulsive, Mood-Psychotic) scores. Neurodevelopmental PGS-associated genes were preferentially expressed in the cerebellum, where their expression peaked prenatally. Further, lower gray matter volumes in cerebellum and functionally coupled cortical regions associated with psychiatric symptoms in mid-childhood. These findings demonstrate that the genetic underpinnings of pediatric psychiatric symptoms differ from those of adult illness, and implicate fetal cerebellar developmental processes that endure through childhood. The authors associate a novel genomic risk score with a broad set of psychiatric symptoms in children. They trace the impact of associated genes on cerebellar developmental processes that originate in fetal life and endure through early adolescence.
AbstractList Childhood psychiatric symptoms are often diffuse but can coalesce into discrete mental illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic risk for childhood symptoms and to uncover related neurodevelopmental mechanisms with transcriptomic and neuroimaging data. In independent samples (Adolescent Brain Cognitive Development, Generation R) a narrow cross-disorder neurodevelopmental PGS, reflecting risk for attention deficit hyperactivity disorder, autism, depression and Tourette syndrome, predicted psychiatric symptoms through early adolescence with greater sensitivity than broad cross-disorder PGSs reflecting shared risk across eight psychiatric disorders, the disorder-specific PGS individually or two other narrow cross-disorder (Compulsive, Mood-Psychotic) scores. Neurodevelopmental PGS-associated genes were preferentially expressed in the cerebellum, where their expression peaked prenatally. Further, lower gray matter volumes in cerebellum and functionally coupled cortical regions associated with psychiatric symptoms in mid-childhood. These findings demonstrate that the genetic underpinnings of pediatric psychiatric symptoms differ from those of adult illness, and implicate fetal cerebellar developmental processes that endure through childhood.Childhood psychiatric symptoms are often diffuse but can coalesce into discrete mental illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic risk for childhood symptoms and to uncover related neurodevelopmental mechanisms with transcriptomic and neuroimaging data. In independent samples (Adolescent Brain Cognitive Development, Generation R) a narrow cross-disorder neurodevelopmental PGS, reflecting risk for attention deficit hyperactivity disorder, autism, depression and Tourette syndrome, predicted psychiatric symptoms through early adolescence with greater sensitivity than broad cross-disorder PGSs reflecting shared risk across eight psychiatric disorders, the disorder-specific PGS individually or two other narrow cross-disorder (Compulsive, Mood-Psychotic) scores. Neurodevelopmental PGS-associated genes were preferentially expressed in the cerebellum, where their expression peaked prenatally. Further, lower gray matter volumes in cerebellum and functionally coupled cortical regions associated with psychiatric symptoms in mid-childhood. These findings demonstrate that the genetic underpinnings of pediatric psychiatric symptoms differ from those of adult illness, and implicate fetal cerebellar developmental processes that endure through childhood.
Childhood psychiatric symptoms are often diffuse but can coalesce into discrete mental illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic risk for childhood symptoms and to uncover related neurodevelopmental mechanisms with transcriptomic and neuroimaging data. In independent samples (Adolescent Brain Cognitive Development, Generation R) a narrow cross-disorder neurodevelopmental PGS, reflecting risk for attention deficit hyperactivity disorder, autism, depression and Tourette syndrome, predicted psychiatric symptoms through early adolescence with greater sensitivity than broad cross-disorder PGSs reflecting shared risk across eight psychiatric disorders, the disorder-specific PGS individually or two other narrow cross-disorder (Compulsive, Mood-Psychotic) scores. Neurodevelopmental PGS-associated genes were preferentially expressed in the cerebellum, where their expression peaked prenatally. Further, lower gray matter volumes in cerebellum and functionally coupled cortical regions associated with psychiatric symptoms in mid-childhood. These findings demonstrate that the genetic underpinnings of pediatric psychiatric symptoms differ from those of adult illness, and implicate fetal cerebellar developmental processes that endure through childhood. The authors associate a novel genomic risk score with a broad set of psychiatric symptoms in children. They trace the impact of associated genes on cerebellar developmental processes that originate in fetal life and endure through early adolescence.
Childhood psychiatric symptoms are often diffuse but can coalesce into discrete mental illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic risk for childhood symptoms and to uncover related neurodevelopmental mechanisms with transcriptomic and neuroimaging data. In independent samples (Adolescent Brain Cognitive Development, Generation R) a narrow cross-disorder neurodevelopmental PGS, reflecting risk for attention deficit hyperactivity disorder, autism, depression and Tourette syndrome, predicted psychiatric symptoms through early adolescence with greater sensitivity than broad cross-disorder PGSs reflecting shared risk across eight psychiatric disorders, the disorder-specific PGS individually or two other narrow cross-disorder (Compulsive, Mood-Psychotic) scores. Neurodevelopmental PGS-associated genes were preferentially expressed in the cerebellum, where their expression peaked prenatally. Further, lower gray matter volumes in cerebellum and functionally coupled cortical regions associated with psychiatric symptoms in mid-childhood. These findings demonstrate that the genetic underpinnings of pediatric psychiatric symptoms differ from those of adult illness, and implicate fetal cerebellar developmental processes that endure through childhood.
Childhood psychiatric symptoms are often diffuse but can coalesce into discrete mental illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic risk for childhood symptoms and to uncover related neurodevelopmental mechanisms with transcriptomic and neuroimaging data. In independent samples (Adolescent Brain Cognitive Development, Generation R) a narrow cross-disorder neurodevelopmental PGS, reflecting risk for attention deficit hyperactivity disorder, autism, depression and Tourette syndrome, predicted psychiatric symptoms through early adolescence with greater sensitivity than broad cross-disorder PGSs reflecting shared risk across eight psychiatric disorders, the disorder-specific PGS individually or two other narrow cross-disorder (Compulsive, Mood-Psychotic) scores. Neurodevelopmental PGS-associated genes were preferentially expressed in the cerebellum, where their expression peaked prenatally. Further, lower gray matter volumes in cerebellum and functionally coupled cortical regions associated with psychiatric symptoms in mid-childhood. These findings demonstrate that the genetic underpinnings of pediatric psychiatric symptoms differ from those of adult illness, and implicate fetal cerebellar developmental processes that endure through childhood.The authors associate a novel genomic risk score with a broad set of psychiatric symptoms in children. They trace the impact of associated genes on cerebellar developmental processes that originate in fetal life and endure through early adolescence.
Author Cecil, Charlotte A. M.
Holt, Daphne J.
Dowling, Kevin F.
Valera, Eve M.
Doyle, Alysa E.
Hughes, Dylan E.
Eryilmaz, Hamdi
Gilman, Jodi M.
Tiemeier, Henning
Bazer, Oren M.
Smoller, Jordan W.
Roffman, Joshua L.
Lee, Phil H.
Elyounssi, Safia
Luo, Mannan
Kunitoki, Keiko
Hopkinson, Casey E.
Dunn, Erin C.
AuthorAffiliation 14 Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands
13 Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia, Rotterdam, the Netherlands
2 Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
10 Center on the Developing Child at Harvard University, Cambridge, MA, USA
6 Medical Scientist Training Program, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, PA, USA
8 Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
3 Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, the Netherlands
15 Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands
5 Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
12 Center for Precision Psychiatry, Massa
AuthorAffiliation_xml – name: 7 Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
– name: 12 Center for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA
– name: 3 Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, the Netherlands
– name: 9 Stanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge, MA, USA
– name: 11 MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
– name: 8 Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
– name: 5 Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
– name: 10 Center on the Developing Child at Harvard University, Cambridge, MA, USA
– name: 16 Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA
– name: 14 Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands
– name: 13 Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia, Rotterdam, the Netherlands
– name: 2 Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
– name: 15 Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands
– name: 6 Medical Scientist Training Program, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, PA, USA
– name: 4 Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
– name: 1 Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Author_xml – sequence: 1
  givenname: Dylan E.
  surname: Hughes
  fullname: Hughes, Dylan E.
  organization: Department of Psychiatry, Massachusetts General Hospital
– sequence: 2
  givenname: Keiko
  orcidid: 0000-0002-7641-5427
  surname: Kunitoki
  fullname: Kunitoki, Keiko
  organization: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School
– sequence: 3
  givenname: Safia
  surname: Elyounssi
  fullname: Elyounssi, Safia
  organization: Department of Psychiatry, Massachusetts General Hospital
– sequence: 4
  givenname: Mannan
  orcidid: 0000-0003-3923-2362
  surname: Luo
  fullname: Luo, Mannan
  organization: Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
– sequence: 5
  givenname: Oren M.
  surname: Bazer
  fullname: Bazer, Oren M.
  organization: Department of Psychiatry, Massachusetts General Hospital
– sequence: 6
  givenname: Casey E.
  surname: Hopkinson
  fullname: Hopkinson, Casey E.
  organization: Department of Psychiatry, Massachusetts General Hospital
– sequence: 7
  givenname: Kevin F.
  orcidid: 0000-0001-5609-7727
  surname: Dowling
  fullname: Dowling, Kevin F.
  organization: Department of Psychiatry, Massachusetts General Hospital, Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Medical Scientist Training Program, University of Pittsburgh and Carnegie Mellon University
– sequence: 8
  givenname: Alysa E.
  surname: Doyle
  fullname: Doyle, Alysa E.
  organization: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Center for Genomic Medicine, Massachusetts General Hospital
– sequence: 9
  givenname: Erin C.
  surname: Dunn
  fullname: Dunn, Erin C.
  organization: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Stanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Center on the Developing Child at Harvard University
– sequence: 10
  givenname: Hamdi
  surname: Eryilmaz
  fullname: Eryilmaz, Hamdi
  organization: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School
– sequence: 11
  givenname: Jodi M.
  orcidid: 0000-0001-5180-6694
  surname: Gilman
  fullname: Gilman, Jodi M.
  organization: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital
– sequence: 12
  givenname: Daphne J.
  surname: Holt
  fullname: Holt, Daphne J.
  organization: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital
– sequence: 13
  givenname: Eve M.
  surname: Valera
  fullname: Valera, Eve M.
  organization: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School
– sequence: 14
  givenname: Jordan W.
  surname: Smoller
  fullname: Smoller, Jordan W.
  organization: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Stanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Center for Precision Psychiatry, Massachusetts General Hospital
– sequence: 15
  givenname: Charlotte A. M.
  surname: Cecil
  fullname: Cecil, Charlotte A. M.
  organization: Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia, Department of Epidemiology, Erasmus MC, Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center
– sequence: 16
  givenname: Henning
  orcidid: 0000-0002-4395-1397
  surname: Tiemeier
  fullname: Tiemeier, Henning
  organization: Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia, Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health
– sequence: 17
  givenname: Phil H.
  surname: Lee
  fullname: Lee, Phil H.
  organization: Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Stanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT
– sequence: 18
  givenname: Joshua L.
  orcidid: 0000-0003-4073-532X
  surname: Roffman
  fullname: Roffman, Joshua L.
  email: jroffman@partners.org
  organization: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37202553$$D View this record in MEDLINE/PubMed
BookMark eNp9kU1vFSEUhompsR_6B1wYEjduRvmYGWBjYhqtJk3c6JowzJk7NAyMwDS5_15ub63aRRcEAs97znt4z9FJiAEQek3Je0q4_JBb2ineEFYX5Yw28hk6o13bN1Sw_qSeiRJNz7r-FJ3nfEMIEZ1UL9ApF4ywruNnaH8FAYqzeDWlQAou7PAUE7az8yNe897OsT7N0cfdHruMR5eLC7bgKcUFl9mUO96Mmy8ZmzBit6zeWVMg4wmK8dhCggG8NwmPcAs-rguE8hI9n4zP8Op-v0A_v3z-cfm1uf5-9e3y03VjW9GWxkz9MBBlJYWBt2DqreUgTMdHA0JZoiZBqVGKUqZ6QY3hfJTtZOuHgKIdv0Afj3XXbVhgtLV1Ml6vyS0m7XU0Tv__Etysd_FWi55WB20t8O6-QIq_NshFLy7bwzwB4pY1k7QXPaOtrOjbR-hN3FKo41WKMSlVq1il3vzr6MHKn1QqwI6ATTHnBNMDQok-RK-P0esavb6LXh96y0ci64opLh6mcv5pKT9Kc-0TdpD-2n5C9RsLfMXA
CitedBy_id crossref_primary_10_12688_f1000research_150931_1
crossref_primary_10_12688_f1000research_150931_2
crossref_primary_10_3389_fncel_2024_1386583
crossref_primary_10_1016_j_jad_2025_03_005
crossref_primary_10_1038_s44220_024_00313_2
crossref_primary_10_1016_j_biopsych_2024_12_021
crossref_primary_10_1016_j_cobeha_2023_101310
crossref_primary_10_1007_s12311_025_01809_y
crossref_primary_10_1002_hbm_26717
crossref_primary_10_1038_s44220_024_00338_7
crossref_primary_10_1111_jcpp_13923
Cites_doi 10.1111/jcpp.13281
10.1038/nn.2741
10.1038/nature15393
10.1016/j.neuron.2019.02.031
10.1111/jcpp.13501
10.1038/nature13772
10.1016/j.biopsych.2019.01.019
10.1016/j.dcn.2018.04.003
10.1038/mp.2017.57
10.1111/j.1600-0447.2009.01422.x
10.1186/1471-2350-11-114
10.1038/s41593-020-0665-z
10.1371/journal.pone.0094398
10.1016/j.neuron.2019.05.002
10.1038/s41386-020-0664-5
10.1016/j.neuroimage.2017.12.059
10.1038/nrn3120
10.1093/schbul/sbaa086
10.1016/j.copsyc.2018.09.002
10.1016/j.dcn.2018.03.001
10.1016/j.neuroimage.2020.117164
10.1001/jamapsychiatry.2015.3058
10.1038/s41588-018-0090-3
10.1038/nature10523
10.1017/S0033291721003639
10.1038/s41467-017-01261-5
10.1176/appi.ajp.2018.18040429
10.1038/s41586-021-03220-z
10.1038/nature16549
10.1016/j.dcn.2018.02.002
10.1001/jamapsychiatry.2018.1334
10.1038/s41588-018-0059-2
10.1038/s41562-019-0566-x
10.1109/TMI.2010.2046908
10.1016/j.biopsych.2020.09.026
10.1080/14734220701490995
10.1038/s41588-019-0439-2
10.1089/bio.2015.0032
10.1016/j.euroneuro.2020.08.007
10.1038/nature08185
10.1038/75556
10.1152/jn.00339.2011
10.1177/2167702620959317
10.1001/jamapsychiatry.2018.3338
10.1016/j.neuroimage.2020.116819
10.1016/j.jaac.2019.08.004
10.1371/journal.pcbi.1004219
10.1016/j.neuron.2014.07.016
10.1016/j.neuroimage.2018.08.003
10.1038/s41588-019-0397-8
10.1038/s41583-019-0152-2
10.1038/s41588-019-0344-8
10.1016/j.cell.2019.11.020
10.1006/nimg.1998.0395
10.1016/j.tics.2019.03.009
10.1177/2167702614560750
10.1016/j.biopsych.2021.11.026
10.15585/mmwr.su7102a1
10.1038/s41467-019-09718-5
10.1016/j.jaac.2020.12.031
10.1038/s41380-017-0010-4
10.1038/s41588-019-0379-x
10.1016/j.biopsych.2006.06.011
10.3389/fnbeh.2019.00099
10.1001/jamapsychiatry.2020.3042
10.1038/nprot.2013.092
10.1016/j.neuroimage.2009.01.045
10.1017/S0954579419000828
10.1038/s41588-018-0269-7
10.1001/jamapsychiatry.2020.0527
10.1038/s41586-022-04492-9
10.1093/nar/gkaa1106
10.1016/j.biopsych.2015.03.024
10.1176/appi.ajp.2018.18070857
10.1093/brain/awh729
10.1016/j.biopsych.2020.06.026
10.1007/s10654-015-9998-4
10.1093/gigascience/giz082
10.3389/fpsyt.2013.00144
10.1038/mp.2017.154
ContentType Journal Article
Copyright The Author(s), under exclusive licence to Springer Nature America, Inc. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
2023. The Author(s), under exclusive licence to Springer Nature America, Inc.
Copyright_xml – notice: The Author(s), under exclusive licence to Springer Nature America, Inc. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
– notice: 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QG
7QP
7QR
7TK
7TM
7U7
7U9
7X7
7XB
88E
88G
8AO
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M2M
M7P
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PSYQQ
Q9U
RC3
7X8
5PM
DOI 10.1038/s41593-023-01321-8
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Animal Behavior Abstracts
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Toxicology Abstracts
Virology and AIDS Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Psychology Database (Alumni)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Psychology Database
Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest One Psychology
ProQuest Central Basic
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest One Psychology
ProQuest Central Student
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
AIDS and Cancer Research Abstracts
ProQuest Central Basic
Toxicology Abstracts
ProQuest Psychology Journals (Alumni)
ProQuest SciTech Collection
ProQuest Medical Library
ProQuest Psychology Journals
Animal Behavior Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

MEDLINE

ProQuest One Psychology
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 1546-1726
EndPage 969
ExternalDocumentID PMC7614744
37202553
10_1038_s41593_023_01321_8
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
  grantid: R01MH120402
  funderid: https://doi.org/10.13039/100000025
– fundername: NIDA NIH HHS
  grantid: U01 DA041134
– fundername: NIDA NIH HHS
  grantid: U01 DA041028
– fundername: NIMH NIH HHS
  grantid: R01 MH120219
– fundername: NIDA NIH HHS
  grantid: U01 DA051016
– fundername: NIDA NIH HHS
  grantid: U24 DA041123
– fundername: NIDA NIH HHS
  grantid: K02 DA052684
– fundername: NIDA NIH HHS
  grantid: U01 DA051039
– fundername: NIDA NIH HHS
  grantid: U01 DA041048
– fundername: NIDA NIH HHS
  grantid: U24 DA041147
– fundername: NIDA NIH HHS
  grantid: U01 DA050989
GroupedDBID ---
-DZ
.55
.GJ
0R~
123
29M
2FS
36B
39C
3V.
4.4
53G
5BI
5RE
70F
7X7
85S
88E
8AO
8FI
8FJ
8R4
8R5
AAEEF
AARCD
AAYZH
AAZLF
ABAWZ
ABDBF
ABIVO
ABJNI
ABLJU
ABUWG
ACBWK
ACGFS
ACIWK
ACNCT
ACPRK
ACUHS
ADBBV
AENEX
AFBBN
AFKRA
AFRAH
AFSHS
AGAYW
AGHTU
AHBCP
AHMBA
AHOSX
AHSBF
AIBTJ
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ARMCB
ASPBG
AVWKF
AXYYD
AZFZN
AZQEC
B0M
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
CCPQU
CS3
D0L
DB5
DU5
DWQXO
EAD
EAP
EBC
EBD
EBS
EE.
EJD
EMB
EMK
EMOBN
EPL
EPS
ESX
EXGXG
F5P
FEDTE
FQGFK
FSGXE
FYUFA
GNUQQ
HCIFZ
HMCUK
HVGLF
HZ~
IAO
IGS
IHR
INH
INR
IPY
ISR
ITC
M1P
M2M
M7P
MVM
N9A
NNMJJ
O9-
ODYON
P2P
PQQKQ
PROAC
PSQYO
PSYQQ
Q2X
RNS
RNT
RNTTT
SHXYY
SIXXV
SNYQT
SOJ
SV3
TAOOD
TBHMF
TDRGL
TSG
TUS
UKHRP
X7M
XJT
YNT
YQT
ZGI
~8M
AAYXX
ABFSG
ACSTC
AEZWR
AFANA
AFHIU
AHWEU
AIXLP
ALPWD
ATHPR
CITATION
NFIDA
PHGZM
PHGZT
ADXHL
AETEA
CGR
CUY
CVF
ECM
EIF
NPM
PJZUB
PPXIY
PQGLB
7QG
7QP
7QR
7TK
7TM
7U7
7U9
7XB
8FD
8FE
8FH
8FK
C1K
FR3
H94
K9.
LK8
P64
PKEHL
PQEST
PQUKI
PUEGO
Q9U
RC3
7X8
5PM
ID FETCH-LOGICAL-c474t-af6bb09c81eb34eac47c3e7a53dae79c09f711a991129671aa33d84fc321e9153
IEDL.DBID 7X7
ISSN 1097-6256
1546-1726
IngestDate Thu Aug 21 18:36:59 EDT 2025
Tue Aug 05 10:32:16 EDT 2025
Sat Aug 23 14:28:47 EDT 2025
Mon Jul 21 06:07:02 EDT 2025
Tue Jul 01 03:21:51 EDT 2025
Thu Apr 24 23:01:42 EDT 2025
Fri Feb 21 02:40:12 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Language English
License 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.
under exclusive licence to Springer Nature America, Inc.
This work is licensed under a CC BY 4.0 International license.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c474t-af6bb09c81eb34eac47c3e7a53dae79c09f711a991129671aa33d84fc321e9153
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
These authors jointly supervised this work: Phil H. Lee, Joshua L. Roffman.
ORCID 0000-0003-3923-2362
0000-0002-7641-5427
0000-0001-5609-7727
0000-0001-5180-6694
0000-0003-4073-532X
0000-0002-4395-1397
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC7614744
PMID 37202553
PQID 2822889492
PQPubID 44706
PageCount 11
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7614744
proquest_miscellaneous_2816762148
proquest_journals_2822889492
pubmed_primary_37202553
crossref_primary_10_1038_s41593_023_01321_8
crossref_citationtrail_10_1038_s41593_023_01321_8
springer_journals_10_1038_s41593_023_01321_8
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-06-01
PublicationDateYYYYMMDD 2023-06-01
PublicationDate_xml – month: 06
  year: 2023
  text: 2023-06-01
  day: 01
PublicationDecade 2020
PublicationPlace New York
PublicationPlace_xml – name: New York
– name: United States
PublicationTitle Nature neuroscience
PublicationTitleAbbrev Nat Neurosci
PublicationTitleAlternate Nat Neurosci
PublicationYear 2023
Publisher Nature Publishing Group US
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group US
– name: Nature Publishing Group
References Tubbs, Ding, Baum, Sham (CR48) 2020; 39
Watanabe, Taskesen, van Bochoven, Posthuma (CR37) 2017; 8
Shaw (CR9) 2019; 31
Penzes, Cahill, Jones, VanLeeuwen, Woolfrey (CR75) 2011; 14
Yu (CR26) 2019; 176
Waszczuk (CR43) 2021; 53
Purcell (CR1) 2009; 460
Hariri (CR49) 2019; 102
Posner, Biezonski, Pieper, Duarte (CR10) 2021; 60
Sekar (CR7) 2016; 530
CR34
Clark (CR33) 2021; 9
Valera, Faraone, Murray, Seidman (CR53) 2007; 61
Miquel, Nicola, Gil-Miravet, Guarque-Chabrera, Sanchez-Hernandez (CR62) 2019; 13
Watson (CR27) 2019; 51
Auchter (CR69) 2018; 32
Murray (CR8) 2021; 78
Schmahmann, Weilburg, Sherman (CR55) 2007; 6
Casey (CR78) 2018; 32
Rosen (CR81) 2018; 169
Steenkamp (CR23) 2021; 62
Stahl (CR3) 2019; 51
Schmahmann, Caplan (CR57) 2006; 129
Reef, Diamantopoulou, van Meurs, Verhulst, van der Ende (CR13) 2009; 120
Lee, Feng, Smoller (CR20) 2021; 89
Kozareva (CR65) 2021; 598
Auton (CR70) 2015; 526
Dale, Fischl, Sereno (CR80) 1999; 9
Kember (CR45) 2021; 89
Martin (CR66) 2019; 51
Choi, O’Reilly (CR71) 2019; 8
Wray (CR24) 2018; 50
Tolosa (CR40) 2010; 11
Sieradzka (CR44) 2014; 9
Moberget (CR51) 2019; 86
Rice (CR47) 2019; 76
Medina-Gomez (CR77) 2015; 30
Feczko (CR14) 2019; 23
Ashburner (CR74) 2000; 25
Pardinas (CR2) 2018; 50
de Leeuw, Mooij, Heskes, Posthuma (CR35) 2015; 11
Smoller (CR22) 2019; 24
Karcher (CR68) 2018; 75
De Rubeis (CR76) 2014; 515
Bitsko (CR46) 2022; 71
Grove (CR4) 2019; 51
Rovira (CR12) 2020; 45
Diedrichsen, Balsters, Flavell, Cussans, Ramnani (CR54) 2009; 46
Marsman (CR19) 2020; 46
Han, Carass, He, Prince (CR41) 2020; 218
CR16
Luking (CR56) 2022; 7
Tustison (CR79) 2010; 29
Grotzinger (CR31) 2019; 3
Vuijk (CR17) 2020; 59
Jernigan, Brown (CR67) 2018; 32
(CR21) 2019; 179
Ge, Chen, Ni, Feng, Smoller (CR32) 2019; 10
Akingbuwa (CR29) 2020; 77
Lee (CR28) 2021; 92
Romer (CR52) 2018; 23
Carass (CR82) 2018; 183
Carithers (CR38) 2015; 13
Brandon, Sawa (CR6) 2011; 12
Kang (CR39) 2011; 478
Mi, Muruganujan, Casagrande, Thomas (CR73) 2013; 8
Neumann (CR30) 2022; 63
Laceulle, Vollebergh, Ormel (CR15) 2015; 3
Buckner, Krienen, Castellanos, Diaz, Yeo (CR42) 2011; 106
Szucs, Ioannidis (CR64) 2020; 221
Demontis (CR11) 2019; 51
CR25
Brady (CR59) 2019; 176
Mi (CR72) 2021; 49
Sathyanesan (CR61) 2019; 20
Kelly (CR50) 2020; 23
Marek (CR63) 2022; 603
Khan (CR58) 2015; 78
Anderson, Shade, DiBlasi, Shabalin, Docherty (CR5) 2019; 27
Koopmans (CR36) 2019; 103
Wang, Kloth, Badura (CR60) 2014; 83
Jones (CR18) 2016; 73
NR Wray (1321_CR24) 2018; 50
HJ Watson (1321_CR27) 2019; 51
NJ Brandon (1321_CR6) 2011; 12
Cross-Disorder Group of the Psychiatric Genomics Consortium. (1321_CR21) 2019; 179
AF Pardinas (1321_CR2) 2018; 50
HJ Jones (1321_CR18) 2016; 73
J Posner (1321_CR10) 2021; 60
PH Lee (1321_CR20) 2021; 89
AM Dale (1321_CR80) 1999; 9
EM Valera (1321_CR53) 2007; 61
LJ Carithers (1321_CR38) 2015; 13
KR Luking (1321_CR56) 2022; 7
E Feczko (1321_CR14) 2019; 23
RO Brady Jr. (1321_CR59) 2019; 176
PH Lee (1321_CR28) 2021; 92
RH Bitsko (1321_CR46) 2022; 71
RL Buckner (1321_CR42) 2011; 106
1321_CR16
AFG Rosen (1321_CR81) 2018; 169
SW Choi (1321_CR71) 2019; 8
J Diedrichsen (1321_CR54) 2009; 46
TL Jernigan (1321_CR67) 2018; 32
A Sekar (1321_CR7) 2016; 530
C Medina-Gomez (1321_CR77) 2015; 30
WA Akingbuwa (1321_CR29) 2020; 77
S De Rubeis (1321_CR76) 2014; 515
K Watanabe (1321_CR37) 2017; 8
S Han (1321_CR41) 2020; 218
D Demontis (1321_CR11) 2019; 51
V Kozareva (1321_CR65) 2021; 598
A Tolosa (1321_CR40) 2010; 11
A Sathyanesan (1321_CR61) 2019; 20
M Miquel (1321_CR62) 2019; 13
JD Schmahmann (1321_CR57) 2006; 129
A Neumann (1321_CR30) 2022; 63
JW Smoller (1321_CR22) 2019; 24
LR Steenkamp (1321_CR23) 2021; 62
T Ge (1321_CR32) 2019; 10
BJ Casey (1321_CR78) 2018; 32
AD Grotzinger (1321_CR31) 2019; 3
H Mi (1321_CR72) 2021; 49
DA Clark (1321_CR33) 2021; 9
D Szucs (1321_CR64) 2020; 221
A Marsman (1321_CR19) 2020; 46
J Grove (1321_CR4) 2019; 51
F Koopmans (1321_CR36) 2019; 103
1321_CR34
D Yu (1321_CR26) 2019; 176
AR Martin (1321_CR66) 2019; 51
HJ Kang (1321_CR39) 2011; 478
D Sieradzka (1321_CR44) 2014; 9
P Penzes (1321_CR75) 2011; 14
JD Schmahmann (1321_CR55) 2007; 6
P Rovira (1321_CR12) 2020; 45
OM Laceulle (1321_CR15) 2015; 3
AL Romer (1321_CR52) 2018; 23
SM Purcell (1321_CR1) 2009; 460
E Kelly (1321_CR50) 2020; 23
AJ Khan (1321_CR58) 2015; 78
A Carass (1321_CR82) 2018; 183
DS Shaw (1321_CR9) 2019; 31
NJ Tustison (1321_CR79) 2010; 29
AR Hariri (1321_CR49) 2019; 102
M Ashburner (1321_CR74) 2000; 25
SS Wang (1321_CR60) 2014; 83
JS Anderson (1321_CR5) 2019; 27
CA de Leeuw (1321_CR35) 2015; 11
RL Kember (1321_CR45) 2021; 89
MA Waszczuk (1321_CR43) 2021; 53
S Marek (1321_CR63) 2022; 603
NR Karcher (1321_CR68) 2018; 75
H Mi (1321_CR73) 2013; 8
PJ Vuijk (1321_CR17) 2020; 59
1321_CR25
JD Tubbs (1321_CR48) 2020; 39
J Reef (1321_CR13) 2009; 120
GK Murray (1321_CR8) 2021; 78
EA Stahl (1321_CR3) 2019; 51
F Rice (1321_CR47) 2019; 76
A Auton (1321_CR70) 2015; 526
T Moberget (1321_CR51) 2019; 86
AM Auchter (1321_CR69) 2018; 32
References_xml – volume: 62
  start-page: 357
  year: 2021
  end-page: 365
  ident: CR23
  article-title: Psychotic experiences and future school performance in childhood: a population-based cohort study
  publication-title: J. Child Psychol. Psychiatry
  doi: 10.1111/jcpp.13281
– volume: 7
  start-page: 397
  year: 2022
  end-page: 405
  ident: CR56
  article-title: Timing and type of early psychopathology symptoms predict longitudinal change in cortical thickness from middle childhood into early adolescence
  publication-title: Biol. Psychiatry Cogn. Neurosci. Neuroimaging
– volume: 14
  start-page: 285
  year: 2011
  end-page: 293
  ident: CR75
  article-title: Dendritic spine pathology in neuropsychiatric disorders
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2741
– volume: 526
  start-page: 68
  year: 2015
  end-page: 74
  ident: CR70
  article-title: A global reference for human genetic variation
  publication-title: Nature
  doi: 10.1038/nature15393
– volume: 102
  start-page: 17
  year: 2019
  end-page: 20
  ident: CR49
  article-title: The emerging importance of the cerebellum in broad risk for psychopathology
  publication-title: Neuron
  doi: 10.1016/j.neuron.2019.02.031
– volume: 63
  start-page: 636
  year: 2022
  end-page: 645
  ident: CR30
  article-title: Combined polygenic risk scores of different psychiatric traits predict general and specific psychopathology in childhood
  publication-title: J. Child Psychol. Psychiatry
  doi: 10.1111/jcpp.13501
– volume: 515
  start-page: 209
  year: 2014
  end-page: 215
  ident: CR76
  article-title: Synaptic, transcriptional and chromatin genes disrupted in autism
  publication-title: Nature
  doi: 10.1038/nature13772
– volume: 86
  start-page: 65
  year: 2019
  end-page: 75
  ident: CR51
  article-title: Cerebellar gray matter volume is associated with cognitive function and psychopathology in adolescence
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2019.01.019
– volume: 32
  start-page: 8
  year: 2018
  end-page: 15
  ident: CR69
  article-title: A description of the ABCD organizational structure and communication framework
  publication-title: Dev. Cogn. Neurosci.
  doi: 10.1016/j.dcn.2018.04.003
– volume: 23
  start-page: 1084
  year: 2018
  end-page: 1090
  ident: CR52
  article-title: Structural alterations within cerebellar circuitry are associated with general liability for common mental disorders
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2017.57
– ident: CR16
– volume: 120
  start-page: 230
  year: 2009
  end-page: 238
  ident: CR13
  article-title: Child to adult continuities of psychopathology: a 24-year follow-up
  publication-title: Acta Psychiatr. Scand.
  doi: 10.1111/j.1600-0447.2009.01422.x
– volume: 11
  year: 2010
  ident: CR40
  article-title: FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies
  publication-title: BMC Med. Genet.
  doi: 10.1186/1471-2350-11-114
– volume: 23
  start-page: 1102
  year: 2020
  end-page: 1110
  ident: CR50
  article-title: Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-020-0665-z
– volume: 9
  start-page: e94398
  year: 2014
  ident: CR44
  article-title: Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence?
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0094398
– volume: 103
  start-page: 217
  year: 2019
  end-page: 234.e4
  ident: CR36
  article-title: SynGO: an evidence-based, expert-curated knowledge base for the synapse
  publication-title: Neuron
  doi: 10.1016/j.neuron.2019.05.002
– volume: 45
  start-page: 1617
  year: 2020
  end-page: 1626
  ident: CR12
  article-title: Shared genetic background between children and adults with attention deficit/hyperactivity disorder
  publication-title: Neuropsychopharmacology
  doi: 10.1038/s41386-020-0664-5
– volume: 169
  start-page: 407
  year: 2018
  end-page: 418
  ident: CR81
  article-title: Quantitative assessment of structural image quality
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2017.12.059
– volume: 12
  start-page: 707
  year: 2011
  end-page: 722
  ident: CR6
  article-title: Linking neurodevelopmental and synaptic theories of mental illness through DISC1
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn3120
– volume: 46
  start-page: 1353
  year: 2020
  end-page: 1362
  ident: CR19
  article-title: Do current measures of polygenic risk for mental disorders contribute to population variance in mental health?
  publication-title: Schizophr. Bull.
  doi: 10.1093/schbul/sbaa086
– volume: 27
  start-page: 77
  year: 2019
  end-page: 81
  ident: CR5
  article-title: Polygenic risk scoring and prediction of mental health outcomes
  publication-title: Curr. Opin. Psychol.
  doi: 10.1016/j.copsyc.2018.09.002
– volume: 32
  start-page: 43
  year: 2018
  end-page: 54
  ident: CR78
  article-title: The Adolescent Brain Cognitive Development (ABCD) study: imaging acquisition across 21 sites
  publication-title: Dev. Cogn. Neurosci.
  doi: 10.1016/j.dcn.2018.03.001
– volume: 221
  start-page: 117164
  year: 2020
  ident: CR64
  article-title: Sample size evolution in neuroimaging research: an evaluation of highly-cited studies (1990–2012) and of latest practices (2017–2018) in high-impact journals
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2020.117164
– volume: 73
  start-page: 221
  year: 2016
  end-page: 228
  ident: CR18
  article-title: Phenotypic manifestation of genetic risk for schizophrenia during adolescence in the general population
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2015.3058
– ident: CR25
– volume: 50
  start-page: 668
  year: 2018
  end-page: 681
  ident: CR24
  article-title: Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0090-3
– volume: 478
  start-page: 483
  year: 2011
  end-page: 479
  ident: CR39
  article-title: Spatio-temporal transcriptome of the human brain
  publication-title: Nature
  doi: 10.1038/nature10523
– volume: 53
  start-page: 1937
  year: 2021
  end-page: 1946
  ident: CR43
  article-title: General v. specific vulnerabilities: polygenic risk scores and higher-order psychopathology dimensions in the Adolescent Brain Cognitive Development (ABCD) Study
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291721003639
– volume: 8
  year: 2017
  ident: CR37
  article-title: Functional mapping and annotation of genetic associations with FUMA
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01261-5
– volume: 176
  start-page: 512
  year: 2019
  end-page: 520
  ident: CR59
  article-title: Cerebellar-prefrontal network connectivity and negative symptoms in schizophrenia
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2018.18040429
– volume: 598
  start-page: 214
  year: 2021
  end-page: 219
  ident: CR65
  article-title: A transcriptomic atlas of mouse cerebellar cortex comprehensively defines cell types
  publication-title: Nature
  doi: 10.1038/s41586-021-03220-z
– volume: 530
  start-page: 177
  year: 2016
  end-page: 183
  ident: CR7
  article-title: Schizophrenia risk from complex variation of complement component 4
  publication-title: Nature
  doi: 10.1038/nature16549
– volume: 32
  start-page: 1
  year: 2018
  end-page: 3
  ident: CR67
  article-title: ABCD Consortium Coordinators. Introduction
  publication-title: Dev. Cogn. Neurosci.
  doi: 10.1016/j.dcn.2018.02.002
– volume: 75
  start-page: 853
  year: 2018
  end-page: 861
  ident: CR68
  article-title: Assessment of the Prodromal Questionnaire–Brief Child Version for measurement of self-reported psychoticlike experiences in childhood
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2018.1334
– volume: 50
  start-page: 381
  year: 2018
  end-page: 389
  ident: CR2
  article-title: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0059-2
– volume: 3
  start-page: 513
  year: 2019
  end-page: 525
  ident: CR31
  article-title: Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits
  publication-title: Nat. Hum. Behav.
  doi: 10.1038/s41562-019-0566-x
– volume: 29
  start-page: 1310
  year: 2010
  end-page: 1320
  ident: CR79
  article-title: N4ITK: improved N3 bias correction
  publication-title: IEEE Trans. Med. Imaging
  doi: 10.1109/TMI.2010.2046908
– volume: 89
  start-page: 20
  year: 2021
  end-page: 31
  ident: CR20
  article-title: Pleiotropy and cross-disorder genetics among psychiatric disorders
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2020.09.026
– volume: 6
  start-page: 254
  year: 2007
  end-page: 267
  ident: CR55
  article-title: The neuropsychiatry of the cerebellum – insights from the clinic
  publication-title: Cerebellum
  doi: 10.1080/14734220701490995
– volume: 51
  start-page: 1207
  year: 2019
  end-page: 1214
  ident: CR27
  article-title: Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0439-2
– volume: 13
  start-page: 311
  year: 2015
  end-page: 319
  ident: CR38
  article-title: A novel approach to high-quality postmortem tissue procurement: the GTEx project
  publication-title: Biopreserv. Biobank.
  doi: 10.1089/bio.2015.0032
– volume: 39
  start-page: 1
  year: 2020
  end-page: 18
  ident: CR48
  article-title: Systemic neuro-dysregulation in depression: evidence from genome-wide association
  publication-title: Eur. Neuropsychopharmacol.
  doi: 10.1016/j.euroneuro.2020.08.007
– volume: 460
  start-page: 748
  year: 2009
  end-page: 752
  ident: CR1
  article-title: Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
  publication-title: Nature
  doi: 10.1038/nature08185
– volume: 25
  start-page: 25
  year: 2000
  end-page: 29
  ident: CR74
  article-title: Gene Ontology: tool for the unification of biology
  publication-title: Nat. Genet.
  doi: 10.1038/75556
– volume: 106
  start-page: 2322
  year: 2011
  end-page: 2345
  ident: CR42
  article-title: The organization of the human cerebellum estimated by intrinsic functional connectivity
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.00339.2011
– volume: 9
  start-page: 169
  year: 2021
  end-page: 182
  ident: CR33
  article-title: The general factor of psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study: a comparison of alternative modeling approaches
  publication-title: Clin. Psychol. Sci.
  doi: 10.1177/2167702620959317
– volume: 76
  start-page: 306
  year: 2019
  end-page: 313
  ident: CR47
  article-title: Characterizing developmental trajectories and the role of neuropsychiatric genetic risk variants in early-onset depression
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2018.3338
– volume: 218
  start-page: 116819
  year: 2020
  ident: CR41
  article-title: Automatic cerebellum anatomical parcellation using U-Net with locally constrained optimization
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2020.116819
– volume: 59
  start-page: 964
  year: 2020
  end-page: 977
  ident: CR17
  article-title: Translating discoveries in attention-deficit/hyperactivity disorder genomics to an outpatient child and adolescent psychiatric cohort
  publication-title: J. Am. Acad. Child Adolesc. Psychiatry
  doi: 10.1016/j.jaac.2019.08.004
– volume: 11
  start-page: e1004219
  year: 2015
  ident: CR35
  article-title: MAGMA: generalized gene-set analysis of GWAS data
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.1004219
– volume: 83
  start-page: 518
  year: 2014
  end-page: 532
  ident: CR60
  article-title: The cerebellum, sensitive periods, and autism
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.07.016
– volume: 183
  start-page: 150
  year: 2018
  end-page: 172
  ident: CR82
  article-title: Comparing fully automated state-of-the-art cerebellum parcellation from magnetic resonance images
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2018.08.003
– volume: 51
  start-page: 793
  year: 2019
  end-page: 803
  ident: CR3
  article-title: Genome-wide association study identifies 30 loci associated with bipolar disorder
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0397-8
– volume: 20
  start-page: 298
  year: 2019
  end-page: 313
  ident: CR61
  article-title: Emerging connections between cerebellar development, behaviour and complex brain disorders
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/s41583-019-0152-2
– volume: 51
  start-page: 431
  year: 2019
  end-page: 444
  ident: CR4
  article-title: Identification of common genetic risk variants for autism spectrum disorder
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0344-8
– volume: 179
  start-page: 1469
  year: 2019
  end-page: 1482.e11
  ident: CR21
  article-title: Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders
  publication-title: Cell
  doi: 10.1016/j.cell.2019.11.020
– volume: 9
  start-page: 179
  year: 1999
  end-page: 194
  ident: CR80
  article-title: Cortical surface-based analysis: I. Segmentation and surface reconstruction
  publication-title: Neuroimage
  doi: 10.1006/nimg.1998.0395
– volume: 23
  start-page: 584
  year: 2019
  end-page: 601
  ident: CR14
  article-title: The heterogeneity problem: approaches to identify psychiatric subtypes
  publication-title: Trends Cogn. Sci.
  doi: 10.1016/j.tics.2019.03.009
– volume: 3
  start-page: 850
  year: 2015
  end-page: 860
  ident: CR15
  article-title: The structure of psychopathology in adolescence: replication of a general psychopathology factor in the TRAILS study
  publication-title: Clin. Psychol. Sci.
  doi: 10.1177/2167702614560750
– volume: 92
  start-page: 236
  year: 2021
  end-page: 245
  ident: CR28
  article-title: Genetic association of attention-deficit/hyperactivity disorder and major depression with suicidal ideation and attempts in children: the Adolescent Brain Cognitive Development Study
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2021.11.026
– volume: 71
  start-page: 1
  year: 2022
  end-page: 42
  ident: CR46
  article-title: Mental health surveillance among children – United States, 2013–2019
  publication-title: MMWR Suppl.
  doi: 10.15585/mmwr.su7102a1
– volume: 10
  year: 2019
  ident: CR32
  article-title: Polygenic prediction via Bayesian regression and continuous shrinkage priors
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-09718-5
– volume: 60
  start-page: 672
  year: 2021
  end-page: 674
  ident: CR10
  article-title: Genetic studies of mental illness: are children being left behind?
  publication-title: J. Am. Acad. Child Adolesc. Psychiatry
  doi: 10.1016/j.jaac.2020.12.031
– volume: 24
  start-page: 409
  year: 2019
  end-page: 420
  ident: CR22
  article-title: Psychiatric genetics and the structure of psychopathology
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-017-0010-4
– volume: 51
  start-page: 584
  year: 2019
  end-page: 591
  ident: CR66
  article-title: Clinical use of current polygenic risk scores may exacerbate health disparities
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0379-x
– volume: 61
  start-page: 1361
  year: 2007
  end-page: 1369
  ident: CR53
  article-title: Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2006.06.011
– volume: 13
  start-page: 99
  year: 2019
  ident: CR62
  article-title: A working hypothesis for the role of the cerebellum in impulsivity and compulsivity
  publication-title: Front. Behav. Neurosci.
  doi: 10.3389/fnbeh.2019.00099
– volume: 78
  start-page: 210
  year: 2021
  end-page: 219
  ident: CR8
  article-title: Could polygenic risk scores be useful in psychiatry?: A review
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2020.3042
– volume: 8
  start-page: 1551
  year: 2013
  end-page: 1566
  ident: CR73
  article-title: Large-scale gene function analysis with the PANTHER classification system
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2013.092
– volume: 46
  start-page: 39
  year: 2009
  end-page: 46
  ident: CR54
  article-title: A probabilistic MR atlas of the human cerebellum
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2009.01.045
– volume: 31
  start-page: 1911
  year: 2019
  end-page: 1921
  ident: CR9
  article-title: Trajectories and predictors of children’s early-starting conduct problems: child, family, genetic, and intervention effects
  publication-title: Dev. Psychopathol.
  doi: 10.1017/S0954579419000828
– volume: 51
  start-page: 63
  year: 2019
  end-page: 75
  ident: CR11
  article-title: Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0269-7
– volume: 77
  start-page: 715
  year: 2020
  end-page: 728
  ident: CR29
  article-title: Genetic associations between childhood psychopathology and adult depression and associated traits in 42998 individuals: a meta-analysis
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2020.0527
– volume: 603
  start-page: 654
  year: 2022
  end-page: 660
  ident: CR63
  article-title: Reproducible brain-wide association studies require thousands of individuals
  publication-title: Nature
  doi: 10.1038/s41586-022-04492-9
– volume: 49
  start-page: D394
  year: 2021
  end-page: D403
  ident: CR72
  article-title: PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa1106
– volume: 78
  start-page: 625
  year: 2015
  end-page: 634
  ident: CR58
  article-title: Cerebro-cerebellar resting-state functional connectivity in children and adolescents with autism spectrum disorder
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2015.03.024
– volume: 176
  start-page: 217
  year: 2019
  end-page: 227
  ident: CR26
  article-title: Interrogating the genetic determinants of Tourette’s syndrome and other tic disorders through genome-wide association studies
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2018.18070857
– volume: 129
  start-page: 290
  year: 2006
  end-page: 292
  ident: CR57
  article-title: Cognition, emotion and the cerebellum
  publication-title: Brain
  doi: 10.1093/brain/awh729
– ident: CR34
– volume: 89
  start-page: 236
  year: 2021
  end-page: 245
  ident: CR45
  article-title: Polygenic risk of psychiatric disorders exhibits cross-trait associations in electronic health record data from European ancestry individuals
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2020.06.026
– volume: 30
  start-page: 317
  year: 2015
  end-page: 330
  ident: CR77
  article-title: Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study
  publication-title: Eur. J. Epidemiol.
  doi: 10.1007/s10654-015-9998-4
– volume: 8
  year: 2019
  ident: CR71
  article-title: PRSice-2: polygenic risk score software for biobank-scale data
  publication-title: Gigascience
  doi: 10.1093/gigascience/giz082
– volume: 51
  start-page: 63
  year: 2019
  ident: 1321_CR11
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0269-7
– volume: 39
  start-page: 1
  year: 2020
  ident: 1321_CR48
  publication-title: Eur. Neuropsychopharmacol.
  doi: 10.1016/j.euroneuro.2020.08.007
– volume: 603
  start-page: 654
  year: 2022
  ident: 1321_CR63
  publication-title: Nature
  doi: 10.1038/s41586-022-04492-9
– volume: 76
  start-page: 306
  year: 2019
  ident: 1321_CR47
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2018.3338
– volume: 78
  start-page: 625
  year: 2015
  ident: 1321_CR58
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2015.03.024
– volume: 9
  start-page: 179
  year: 1999
  ident: 1321_CR80
  publication-title: Neuroimage
  doi: 10.1006/nimg.1998.0395
– volume: 103
  start-page: 217
  year: 2019
  ident: 1321_CR36
  publication-title: Neuron
  doi: 10.1016/j.neuron.2019.05.002
– volume: 169
  start-page: 407
  year: 2018
  ident: 1321_CR81
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2017.12.059
– volume: 62
  start-page: 357
  year: 2021
  ident: 1321_CR23
  publication-title: J. Child Psychol. Psychiatry
  doi: 10.1111/jcpp.13281
– volume: 50
  start-page: 668
  year: 2018
  ident: 1321_CR24
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0090-3
– volume: 221
  start-page: 117164
  year: 2020
  ident: 1321_CR64
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2020.117164
– volume: 50
  start-page: 381
  year: 2018
  ident: 1321_CR2
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0059-2
– volume: 8
  start-page: 1551
  year: 2013
  ident: 1321_CR73
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2013.092
– ident: 1321_CR16
  doi: 10.3389/fpsyt.2013.00144
– volume: 75
  start-page: 853
  year: 2018
  ident: 1321_CR68
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2018.1334
– volume: 46
  start-page: 1353
  year: 2020
  ident: 1321_CR19
  publication-title: Schizophr. Bull.
  doi: 10.1093/schbul/sbaa086
– volume: 218
  start-page: 116819
  year: 2020
  ident: 1321_CR41
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2020.116819
– volume: 20
  start-page: 298
  year: 2019
  ident: 1321_CR61
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/s41583-019-0152-2
– volume: 51
  start-page: 584
  year: 2019
  ident: 1321_CR66
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0379-x
– volume: 59
  start-page: 964
  year: 2020
  ident: 1321_CR17
  publication-title: J. Am. Acad. Child Adolesc. Psychiatry
  doi: 10.1016/j.jaac.2019.08.004
– volume: 60
  start-page: 672
  year: 2021
  ident: 1321_CR10
  publication-title: J. Am. Acad. Child Adolesc. Psychiatry
  doi: 10.1016/j.jaac.2020.12.031
– volume: 460
  start-page: 748
  year: 2009
  ident: 1321_CR1
  publication-title: Nature
  doi: 10.1038/nature08185
– volume: 61
  start-page: 1361
  year: 2007
  ident: 1321_CR53
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2006.06.011
– volume: 14
  start-page: 285
  year: 2011
  ident: 1321_CR75
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2741
– volume: 51
  start-page: 793
  year: 2019
  ident: 1321_CR3
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0397-8
– volume: 73
  start-page: 221
  year: 2016
  ident: 1321_CR18
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2015.3058
– volume: 7
  start-page: 397
  year: 2022
  ident: 1321_CR56
  publication-title: Biol. Psychiatry Cogn. Neurosci. Neuroimaging
– volume: 53
  start-page: 1937
  year: 2021
  ident: 1321_CR43
  publication-title: Psychol. Med.
  doi: 10.1017/S0033291721003639
– volume: 32
  start-page: 8
  year: 2018
  ident: 1321_CR69
  publication-title: Dev. Cogn. Neurosci.
  doi: 10.1016/j.dcn.2018.04.003
– volume: 102
  start-page: 17
  year: 2019
  ident: 1321_CR49
  publication-title: Neuron
  doi: 10.1016/j.neuron.2019.02.031
– volume: 11
  year: 2010
  ident: 1321_CR40
  publication-title: BMC Med. Genet.
  doi: 10.1186/1471-2350-11-114
– volume: 49
  start-page: D394
  year: 2021
  ident: 1321_CR72
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa1106
– volume: 8
  year: 2017
  ident: 1321_CR37
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01261-5
– volume: 31
  start-page: 1911
  year: 2019
  ident: 1321_CR9
  publication-title: Dev. Psychopathol.
  doi: 10.1017/S0954579419000828
– ident: 1321_CR34
– volume: 89
  start-page: 236
  year: 2021
  ident: 1321_CR45
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2020.06.026
– volume: 6
  start-page: 254
  year: 2007
  ident: 1321_CR55
  publication-title: Cerebellum
  doi: 10.1080/14734220701490995
– volume: 25
  start-page: 25
  year: 2000
  ident: 1321_CR74
  publication-title: Nat. Genet.
  doi: 10.1038/75556
– volume: 63
  start-page: 636
  year: 2022
  ident: 1321_CR30
  publication-title: J. Child Psychol. Psychiatry
  doi: 10.1111/jcpp.13501
– volume: 515
  start-page: 209
  year: 2014
  ident: 1321_CR76
  publication-title: Nature
  doi: 10.1038/nature13772
– volume: 71
  start-page: 1
  year: 2022
  ident: 1321_CR46
  publication-title: MMWR Suppl.
  doi: 10.15585/mmwr.su7102a1
– volume: 3
  start-page: 850
  year: 2015
  ident: 1321_CR15
  publication-title: Clin. Psychol. Sci.
  doi: 10.1177/2167702614560750
– volume: 46
  start-page: 39
  year: 2009
  ident: 1321_CR54
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2009.01.045
– volume: 13
  start-page: 311
  year: 2015
  ident: 1321_CR38
  publication-title: Biopreserv. Biobank.
  doi: 10.1089/bio.2015.0032
– volume: 10
  year: 2019
  ident: 1321_CR32
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-09718-5
– volume: 13
  start-page: 99
  year: 2019
  ident: 1321_CR62
  publication-title: Front. Behav. Neurosci.
  doi: 10.3389/fnbeh.2019.00099
– volume: 51
  start-page: 431
  year: 2019
  ident: 1321_CR4
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0344-8
– volume: 12
  start-page: 707
  year: 2011
  ident: 1321_CR6
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn3120
– volume: 92
  start-page: 236
  year: 2021
  ident: 1321_CR28
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2021.11.026
– volume: 11
  start-page: e1004219
  year: 2015
  ident: 1321_CR35
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.1004219
– volume: 23
  start-page: 1084
  year: 2018
  ident: 1321_CR52
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2017.57
– volume: 78
  start-page: 210
  year: 2021
  ident: 1321_CR8
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2020.3042
– volume: 89
  start-page: 20
  year: 2021
  ident: 1321_CR20
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2020.09.026
– volume: 120
  start-page: 230
  year: 2009
  ident: 1321_CR13
  publication-title: Acta Psychiatr. Scand.
  doi: 10.1111/j.1600-0447.2009.01422.x
– volume: 478
  start-page: 483
  year: 2011
  ident: 1321_CR39
  publication-title: Nature
  doi: 10.1038/nature10523
– volume: 23
  start-page: 584
  year: 2019
  ident: 1321_CR14
  publication-title: Trends Cogn. Sci.
  doi: 10.1016/j.tics.2019.03.009
– volume: 32
  start-page: 1
  year: 2018
  ident: 1321_CR67
  publication-title: Dev. Cogn. Neurosci.
  doi: 10.1016/j.dcn.2018.02.002
– volume: 526
  start-page: 68
  year: 2015
  ident: 1321_CR70
  publication-title: Nature
  doi: 10.1038/nature15393
– volume: 179
  start-page: 1469
  year: 2019
  ident: 1321_CR21
  publication-title: Cell
  doi: 10.1016/j.cell.2019.11.020
– volume: 3
  start-page: 513
  year: 2019
  ident: 1321_CR31
  publication-title: Nat. Hum. Behav.
  doi: 10.1038/s41562-019-0566-x
– volume: 45
  start-page: 1617
  year: 2020
  ident: 1321_CR12
  publication-title: Neuropsychopharmacology
  doi: 10.1038/s41386-020-0664-5
– volume: 530
  start-page: 177
  year: 2016
  ident: 1321_CR7
  publication-title: Nature
  doi: 10.1038/nature16549
– volume: 176
  start-page: 217
  year: 2019
  ident: 1321_CR26
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2018.18070857
– volume: 183
  start-page: 150
  year: 2018
  ident: 1321_CR82
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2018.08.003
– volume: 32
  start-page: 43
  year: 2018
  ident: 1321_CR78
  publication-title: Dev. Cogn. Neurosci.
  doi: 10.1016/j.dcn.2018.03.001
– volume: 77
  start-page: 715
  year: 2020
  ident: 1321_CR29
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2020.0527
– volume: 24
  start-page: 409
  year: 2019
  ident: 1321_CR22
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-017-0010-4
– volume: 106
  start-page: 2322
  year: 2011
  ident: 1321_CR42
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.00339.2011
– volume: 8
  year: 2019
  ident: 1321_CR71
  publication-title: Gigascience
  doi: 10.1093/gigascience/giz082
– volume: 9
  start-page: e94398
  year: 2014
  ident: 1321_CR44
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0094398
– volume: 51
  start-page: 1207
  year: 2019
  ident: 1321_CR27
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0439-2
– volume: 598
  start-page: 214
  year: 2021
  ident: 1321_CR65
  publication-title: Nature
  doi: 10.1038/s41586-021-03220-z
– volume: 27
  start-page: 77
  year: 2019
  ident: 1321_CR5
  publication-title: Curr. Opin. Psychol.
  doi: 10.1016/j.copsyc.2018.09.002
– volume: 23
  start-page: 1102
  year: 2020
  ident: 1321_CR50
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-020-0665-z
– volume: 30
  start-page: 317
  year: 2015
  ident: 1321_CR77
  publication-title: Eur. J. Epidemiol.
  doi: 10.1007/s10654-015-9998-4
– ident: 1321_CR25
  doi: 10.1038/mp.2017.154
– volume: 86
  start-page: 65
  year: 2019
  ident: 1321_CR51
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2019.01.019
– volume: 9
  start-page: 169
  year: 2021
  ident: 1321_CR33
  publication-title: Clin. Psychol. Sci.
  doi: 10.1177/2167702620959317
– volume: 129
  start-page: 290
  year: 2006
  ident: 1321_CR57
  publication-title: Brain
  doi: 10.1093/brain/awh729
– volume: 83
  start-page: 518
  year: 2014
  ident: 1321_CR60
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.07.016
– volume: 29
  start-page: 1310
  year: 2010
  ident: 1321_CR79
  publication-title: IEEE Trans. Med. Imaging
  doi: 10.1109/TMI.2010.2046908
– volume: 176
  start-page: 512
  year: 2019
  ident: 1321_CR59
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2018.18040429
SSID ssj0007589
Score 2.5003502
Snippet Childhood psychiatric symptoms are often diffuse but can coalesce into discrete mental illnesses during late adolescence. We leveraged polygenic scores (PGSs)...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 959
SubjectTerms 38/43
59/57
631/208/205/2138
631/208/366
631/378/1689/2608
631/378/2632/1368
Adolescent
Adolescents
Adult
Animal Genetics and Genomics
Attention Deficit Disorder with Hyperactivity - genetics
Attention deficit hyperactivity disorder
Autism
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain - pathology
Cerebellum
Cerebellum - diagnostic imaging
Child
Child development
Children
Cognition
Cognitive ability
Fetuses
Genes
Genomics
Gilles de la Tourette syndrome
Gray Matter
Humans
Illnesses
Medical imaging
Mental disorders
Neurobiology
Neurodevelopmental disorders
Neuroimaging
Neurosciences
Pattern formation
Pediatrics
Psychopathology
Risk
Risk sharing
Signs and symptoms
Substantia grisea
Transcriptomics
Title Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development
URI https://link.springer.com/article/10.1038/s41593-023-01321-8
https://www.ncbi.nlm.nih.gov/pubmed/37202553
https://www.proquest.com/docview/2822889492
https://www.proquest.com/docview/2816762148
https://pubmed.ncbi.nlm.nih.gov/PMC7614744
Volume 26
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED_B9sILAsZHYExGQryAtTh2Y-cJtWjVhESFEJP6Fjm2o1WCtDTZw_577pw0VZnYUx5yVZPc-e533wDvnU1DcLnlDl0erpQ33BhZc2XDpBDSeSmoOfnbIr-8Ul-Xk-UQcGuHssqdToyK2q8dxcjPqdzRmEIV2efNH05boyi7OqzQeAjHNLqMpFovR4cLrWFcgUdJVo44Px-aZlJpzls0XFS5llE1kcwEN4eG6Q7avFs0-U_mNBqk-RN4PCBJNu1Z_xQehOYZnEwb9KJ_37IPLNZ2xqD5CdzSdGmkY5s4TpNiIQzRKout3KzvxKLdxJGcrVrm6eg3rmPUfsK6a9tF-jito2W28Ww1lKKHltUBETxzYRsoi2G3zO8rkZ7D1fzi55dLPixd4E5p1XFb51WVFs4IdLMVqmWlnQzaTqS3QRcuLWothEVYiUgh18JaKb1RtcOPGArUny_gqFk34RUwEWpNmdPCZ6gaallUAcFmldrK10qlIQGx--KlGyaS02KMX2XMjEtT9lwqkUtl5FJpEvg4_mbTz-O4l_p0x8hyOJttuZekBN6Nt_FUUarENmF9QzQiRzOBvmICL3u-j39He33QEZMJ6AOJGAloYvfhnWZ1HSd3awRDWqkEPu1kZ_9Y_3-L1_e_xRt4lEU5ptDQKRx125vwFpFSV53F43AGx9P5bLbA6-xi8f3HX13GFS4
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB5V5QAXBJRHoICRgAtEjWNv7BwQqoBqSx-nVtpbcGxHXalkl00qtH-K38iMk-xqqeitZ0-eM56Zz_MCeGtN4r3NTGwR8sRSOh1rLapYGj_KubBOcCpOPjnNxufy-2Q02YI_Qy0MpVUOOjEoajezdEa-R-mOWucyTz_Pf8U0NYqiq8MIjU4sjvzyN0K25tPhV-TvuzQ9-Hb2ZRz3UwViK5VsY1NlZZnkVnPEkRL1jlRWeGVGwhmvcpvkleLcoN-EpjBT3BghnJaVFSn3OacpEajy76DhTQjsqckK4KH1DSP3KKgbI67I-iKdROi9Bg0lZcqllL2Ed4r1piG85t1eT9L8J1IbDODBA7jfe65svxO1h7Dl60ews18jav-5ZO9ZyCUNh_Q7sKRu1kjH5qF9J529MPSOWSgdZ13lF81CDuRs2jBHqqa2LaNyF9ZemDbQh-4gDTO1Y9M-9d03rPKIGJj1C09RE7Ngbp359BjOb4UdT2C7ntX-GTDuK0WR2tylqIoqkZcendsyMaWrpEx8BHz444XtO6DTII7LIkTihS46LhXIpSJwqdARfFhdM-_6f9xIvTswsuh1QVOsJTeCN6tl3MUUmjG1n10RDc_QLCE2jeBpx_fV42iOEAI_EYHakIgVAXUI31yppxehU7hC50tJGcHHQXbWr_X_r3h-81e8hrvjs5Pj4vjw9OgF3EuDTNOx1C5st4sr_xK9tLZ8FbYGgx-3vRf_AlaJTxU
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELemTkK8IGB8ZAwwEvACUePYje0HhAZbtTGoJsSkvQXHdrRKkJYmE-q_xl_HnZO0KhN727Mvn3e-D9_v7gh5aU3ivc1MbCHkiYVwKlaKl7EwfqQZt44zLE7-MsmOzsSn89H5FvnT18IgrLLXiUFRu5nFM_Ihwh2V0kKnw7KDRZwejN_Pf8U4QQozrf04jVZETvzyN4Rv9bvjA-D1qzQdH377eBR3EwZiK6RoYlNmRZFoqxjElAJ0kJCWe2lG3BkvtU10KRkz4EOBWcwkM4Zzp0Rpecq8ZjgxAtT_tsSoaEC2PxxOTr-u7AB44jrkWrWMIcrIupKdhKthDWYTcXMpYpngXrHaNItXfN2rkM1_8rbBHI7vkjudH0v3W8G7R7Z8dZ_s7FcQw_9c0tc0IEvDkf0OWWJva6Cj89DME09iKPjKNBSS07YODCcjB3I6ralDxVPZhmLxC20uTBPoQ6-QmprK0WkHhPc1LT3ED9T6hcccillQt8ZBPSBnN8KQh2RQzSr_mFDmS4l5W-1SUEwl14UHV7dITOFKIRIfEdb_8dx2_dBxLMePPOTlucpbLuXApTxwKVcRebO6Zt52A7mWeq9nZN5phjpfy3FEXqyWYU9josZUfnaJNCwDIwWRakQetXxfPQ6nCkEYyCMiNyRiRYD9wjdXqulF6BsuwRWTQkTkbS8769f6_1fsXv8Vz8kt2If55-PJyRNyOw0ijWdUe2TQLC79U3DZmuJZtzco-X7T2_EvriRUsA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+patterning+for+child+psychopathology+is+distinct+from+that+for+adults+and+implicates+fetal+cerebellar+development&rft.jtitle=Nature+neuroscience&rft.au=Hughes%2C+Dylan+E.&rft.au=Kunitoki%2C+Keiko&rft.au=Elyounssi%2C+Safia&rft.au=Luo%2C+Mannan&rft.date=2023-06-01&rft.issn=1097-6256&rft.eissn=1546-1726&rft.volume=26&rft.issue=6&rft.spage=959&rft.epage=969&rft_id=info:doi/10.1038%2Fs41593-023-01321-8&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41593_023_01321_8
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1097-6256&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1097-6256&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1097-6256&client=summon