Population pharmacokinetic analysis of blood concentrations of robenacoxib in dogs with osteoarthritis

• Published in: Research in veterinary science Vol. 95; no. 2; pp. 580 - 587
• Main Authors: Fink, M., Letellier, I., Peyrou, M., Mochel, J.P., Jung, M., King, J.N., Gruet, P., Giraudel, J.M.
• Format: Journal Article
• Language: English
• Published: England Elsevier India Pvt Ltd 01.10.2013; Elsevier Limited
• Subjects: Age; analogs & derivatives; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Inflammatory Agents, Non-Steroidal - blood; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics; Blood; Body Weight; Chronic Disease; COXIB; Diphenylamine; Diphenylamine - analogs & derivatives; Diphenylamine - blood; Diphenylamine - pharmacokinetics; Dog; Dog Diseases; Dog Diseases - blood; Dog Diseases - drug therapy; Dogs; drug therapy; Female; hematologic tests; kidneys; liver; Male; osteoarthritis; Osteoarthritis - blood; Osteoarthritis - drug therapy; Osteoarthritis - veterinary; patients; pharmacokinetics; Phenylacetates; Phenylacetates - blood; Phenylacetates - pharmacokinetics; population characteristics; Population pharmacokinetics; Robenacoxib; Sex Factors; veterinary; Veterinary medicine; France; Switzerland; LLOQ; Population pharmacokinetics; RSE; BLQ; NSAID; FOCE; EBEs; COX; AUC; Robenacoxib; COXIB; IOV; OA; IIV; Dog; OFV; osteoarthritis; inter-occasion variability; objective function value; non-steroidal anti-inflammatory drug; lower limit of quantification; cyclooxygenase; area under the curve; first order conditional estimation method; relative standard error; below limit of quantification; inter-individual variability; empiricial Bayes estimates

The purpose of this analysis was to investigate whether the recommended daily dosage of 1–2mg/kg robenacoxib provides consistent exposure when administered to dogs with chronic osteoarthritis (OA), and the need for dose adjustment in special patient populations. Data from three prospective, multi-ce...