NGF monoclonal antibody DS002 alleviates chemotherapy-induced peripheral neuropathy in rats

• Published in: Acta pharmacologica Sinica Vol. 43; no. 11; pp. 2841 - 2847
• Main Authors: Liang, Zhi-juan, Tan, Jie, Tang, Lei, Xie, Zuo-bin, Chen, Gan-jun, Liu, Guo-jian, Yuan, Lin, Wang, Kai-xin, Ding, Hua-ping, Qiu, Hong, Wang, Qi, Wang, Gui-feng, Chen, Yi-li, Wang, Chun-he
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.11.2022; Nature Publishing Group
• Subjects: Analgesics; Animal models; Biomedical and Life Sciences; Biomedicine; Cell proliferation; Chemotherapy; Cisplatin; Immunology; Internal Medicine; Medical Microbiology; Monoclonal antibodies; Nerve growth factor; Neurotrophic factors; Paclitaxel; Pain; Peripheral neuropathy; Pharmacology/Toxicology; Quality of life; Signal transduction; Therapeutic targets; TrkA protein; TrkA receptors; Tropomyosin; Vaccine; Vincristine; neuropathic pain; monoclonal antibody; nerve growth factor; chemotherapy

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the pervasive side effects of chemotherapy, leading to poor quality of life in cancer patients. Discovery of powerful analgesics for CIPN is an urgent and substantial clinical need. Nerve growth factor (NGF), a classic neurotrophic factor,...