Inflammation and fibrosis in Crohn’s disease: location-matched histological correlation of small bowel ultrasound features

• Published in: Abdominal imaging Vol. 46; no. 1; pp. 144 - 155
• Main Authors: Bhatnagar, Gauraang, Rodriguez-Justo, Manuel, Higginson, Antony, Bassett, Paul, Windsor, Alastair, Cohen, Richard, Halligan, Steve, Taylor, Stuart A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2021; Springer Nature B.V
• Subjects: Adult; Biomarkers; Clarity; Crohn Disease - diagnostic imaging; Crohn Disease - pathology; Crohn's disease; Fibrosis; Gastroenterology; Hepatology; Hollow Organ GI; Humans; Imaging; Inflammation; Inflammation - diagnostic imaging; Inflammation - pathology; Intestine, Small - diagnostic imaging; Intestine, Small - pathology; Male; Medicine; Medicine & Public Health; Mucosa; Parameters; Phenotypes; Radiology; Regression analysis; Small intestine; Ultrasonic imaging; Ultrasonography; Ultrasound; Wall thickness; Inflammation; Ultrasound; Fibrosis; Crohn’s disease
• ISSN: 2366-004X; 2366-0058; 2366-0058
• DOI: 10.1007/s00261-020-02603-6

Purpose To evaluate the utility of mural and extramural sonographic features of Crohn’s Disease as potential imaging biomarkers of inflammation and fibrosis against whole-mount histological sections. Methods Twelve Crohn’s disease patients (Mean age 35(25–69), 7 males) underwent small bowel ultrasou...