Acute liver injury induced by carbon tetrachloride reversal by Gandankang aqueous extracts through nuclear factor erythroid 2-related factor 2 signaling pathway

• Published in: Ecotoxicology and environmental safety Vol. 251; p. 114527
• Main Authors: Wei, Yuan-yuan, Wang, Hui-ru, Fan, Yi-meng, Gu, Jin-hua, Zhang, Xiu-ying, Gong, Xu-hao, Hao, Zhi-hui
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.02.2023; Elsevier
• Subjects: Acute liver injury; Animals; Antioxidants - metabolism; Carbon Tetrachloride - metabolism; Carbon Tetrachloride - toxicity; Chemical and Drug Induced Liver Injury - metabolism; Compound Chinese medicine; Kelch-Like ECH-Associated Protein 1 - metabolism; Liver; Mice; NF-E2-Related Factor 2 - metabolism; Nuclear Factor Erythroid 2-Related Factor 2; Oxidative Stress; Signal Transduction; Nuclear Factor Erythroid 2-Related Factor 2; Compound Chinese medicine; Acute liver injury

The aims of this study were to evaluated the effect and underlying mechanism of Gandankang (GDK) aqueous extract in alleviating the acute liver injury induced by carbon tetrachloride (CCl4) in vivo and in vitro. Mice were divided into 5 groups (n = 8) for acute (Groups: control, 0.3 % CCl4, BD (Bife...