Juvenile bovine bone is an appropriate surrogate for normal and reduced density human bone in biomechanical testing: a validation study

• Published in: Scientific reports Vol. 8; no. 1; pp. 10181 - 9
• Main Authors: Fletcher, J. W. A., Williams, S., Whitehouse, M. R., Gill, H. S., Preatoni, E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.07.2018; Nature Publishing Group
• Subjects: 631/61/54/990; 692/308/2778; Age Factors; Animals; Biomechanical Phenomena; Biomechanics; Bone Demineralization Technique - methods; Bone density; Bone Density - drug effects; Bones; Cattle; Disease Models, Animal; Ethics; Femur; Humanities and Social Sciences; Humans; Humerus; Hydrochloric acid; Hydrochloric Acid - administration & dosage; Long bone; Materials Testing - instrumentation; Materials Testing - methods; multidisciplinary; Osteoporosis; Osteoporosis - surgery; Pedicle Screws; Science; Science (multidisciplinary); Tibia; Ulna

Orthopaedic research necessitates accurate and reliable models of human bone to enable biomechanical discoveries and translation into clinical scenarios. Juvenile bovine bone is postulated to be a potential model of normal human bone given its dimensions and comparatively reduced ethical restriction...